Evaluation of the acute and chronic toxicity of the jiangu capsules

Abstract

Abstract. Saussureae involucratae Flos is the primary component of the jiangu capsule, which also consists of 12 types of natural medicine. It is a traditional Chinese medicine used to treat a number of conditions including arthralgia, cold and sore muscles, stiff limbs, inconvenient flexion and activity limitation caused by different types of osteoarthritis. The present study was performed to assess the safety of the jiangu capsule following acute and chronic administration in mice and rats. In the acute study, mice were treated with the jiangu capsule orally at 16 g/kg/day, the highest dose, for 14 days. In the chronic oral toxicity study, rats were treated with 2, 4 and 8 g/kg/day of the jiangu capsule for 6 months. The general condition, body weight changes, food and water consumption, hematological and biochemical parameters, urinalysis, systematic anatomy and organ weights of the rats were monitored and histopathological examination was performed at the end of 3 and 6 months' daily administration, and following 14 days of withdrawal. There were no signs of toxicity in the general condition and body weight of the mice was not significantly affected by the treatment. Furthermore, necropsy findings for the animals in the acute and chronic toxicity studies demonstrated that no mortalities had occurred. The results of the current study indicate that treatment with the jiangu capsule did not induce mortality or any detectable abnormalities in mice and rats.

Evaluation of Acute and Subchronic Toxicity Induced by the Crude Ethanol Extract of Plukenetia volubilis Linneo Leaves in Swiss Albino Mice

“…The treatment groups were orally administered with the EtPV in 8 small fractions during 16 hours at doses of 1000, 3000, 5000, and 7000 mg/kg after fasting overnight, whereas the control group was given distilled water. General changes (changes in the skin, hair, eyes, mucous membranes, and respiratory, circulatory, autonomic, and central nervous systems, motor activity, convulsion, tremors, salivation, diarrhea, lethargy, or sleep) and signs of toxicity and mortality were observed for every hour during 24 h after dosing, and further observation was conducted for 14 consecutive days [ 35 ]. The animals were finally lethal by inhalation of CO 2 on sacrifice day [ 36 , 37 ], and the internal organs were collected for relative weight and histopathological evaluation.…”

Effect of Curcuma longa on T lymphocytes in rats induced to prostate cancer

“…Al final del ensayo, las ratas se eutanizaron con pentobarbital a 100 mg/kg, por vía intraperitoneal. Los órganos fueron conservados en formol al 10% para luego realizar el examen anatomopatológico de la próstata y determinar la presencia de cambios en relación a los grupos control 10,11 .…”