Evaluation of the Acutely Dyspneic Elderly Patient

Torres, Mercedes; Moayedi, Siamak

doi:10.1016/j.cger.2007.01.007

Cited by 48 publications

(27 citation statements)

References 33 publications

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“…Chest pain is the most common symptom of AMI, and when due to ischemia of the heart muscle, it is termed angina pectoris.Acute coronary syndrome (ACS), characterized with chest pain, refers to any group of symptoms attributed to obstruction of the coronary arteries. ACS frequently occurs as a result of ST elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI), or unstable angina [90]. …”

Section: Micrornas In Age-related Cardiovascular Diseasesmentioning

confidence: 99%

MicroRNAs Expression Profiles in Cardiovascular Diseases

Bronze-da-Rocha

2014

BioMed Research International

149

117

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The current search for new markers of cardiovascular diseases (CVDs) is explained by the high morbidity and mortality still observed in developed and developing countries due to cardiovascular events. Recently, microRNAs (miRNAs or miRs) have emerged as potential new biomarkers and are small sequences of RNAs that regulate gene expression at posttranscriptional level by inhibiting translation or inducing degradation of the target mRNAs. Circulating miRNAs are involved in the regulation of signaling pathways associated to aging and can be used as novel diagnostic markers for acute and chronic diseases such as cardiovascular pathologies. This review summarizes the biogenesis, maturation, and stability of miRNAs and their use as potential biomarkers for coronary artery disease (CAD), myocardial infarction (MI), and heart failure (HF).

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Section: Micrornas In Age-related Cardiovascular Diseasesmentioning

confidence: 99%

MicroRNAs Expression Profiles in Cardiovascular Diseases

Bronze-da-Rocha

2014

BioMed Research International

149

117

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“…In some countries, mortality rate has decreased in men but has increased in women (43). This is most likely due to rates of smoking in women and men becoming more similar COPD is more common in older people; it affects 34-200 out of 1000 people older than 65 years, depending on the population looked at (3,6,44 (48). The major limitations of this study is lack of databases and indicators amounts that for solve this lack we used the values of the WHO (Middle East) for calculated health effects attribute nitrogen dioxide.…”

Section: Discussionmentioning

confidence: 99%

An Association between air quality and COPD in Ahvaz, Iran

Mohammadi

Godini

Khak

et al. 2015

Jundishapur J Chronic Dis Care

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“…Each proatherogenic lipoprotein fraction: VLDL, IDL, and LDL contains one apo B molecule per particle, therefore the serum concentration of apo B reflects the total number of atherogenic particles (2). HDL is the only antiatherogenic lipoprotein and its major structural protein is apo A-I.…”

Section: Introductionmentioning

confidence: 99%

How Do Apolipoproteins ApoB and ApoA-I Perform in Patients with Acute Coronary Syndromes

Sypniewska¹,

Bergmann²,

Krintus³

et al. 2011

Journal of Medical Biochemistry

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How Do Apolipoproteins ApoB and ApoA-I Perform in Patients with Acute Coronary SyndromesAcute coronary syndromes are the leading cause of hospitalization and death. Results from recent studies suggest that apolipoprotein measurement and apoB:apoA-I are superior to traditional lipids in the estimation of coronary risk. We compared apolipoprotein concentrations and apoB:apoA-I with traditional lipid measures and atherogenic indices in patients diagnosed with acute coronary syndromes (ACS) within 6 hrs from the onset of chest pain. A study group consisted of 227 patients diagnosed with ACS (STEMI=60, NSTEMI=66 and UA=105). Clinically healthy volunteers (n=85) served as controls. Measurements of cardiac TnI, lipid profile, hsCRP, apolipoprotein A-I and apoB100 were performed and apoB:apoA-I, TC-HDL-C, LDL-C:HDL-C ratios were calculated. Patients had increased LDL-C (>3.0 mmol/L) and non-HDL-C (>3.4 mmol/L). Triglycerides were below the cut-off value, but patients had significantly higher TG concentrations and lower HDL-C compared to controls (p<0.001). Apo B and apoA-I concentration in patients remained within the accepted range. Atherogenic indices TC:HDL-C, LDL-C:HDL-C and apoB:apoA-I were significantly increased in patients. ApoB:apoA-I ratio in ACS males was within low risk whereas in females corresponded to medium risk. ApoB:apoA-I and LDL-C:HDL-C ratios were of good diagnostic utility for discrimination between patients and controls (AUC 0.71 and 0.79; respectively). ApoB:apoA-I and LDL-C:HDL-C were of very good diagnostic utility for discrimination between STEMI patients and controls (AUC 0.80 and 0.84). We could not show the superiority of apoB:apoA-I over LDL-C:HDL-C as the discrimination power of both was almost identical. Determination of apolipoproteins should not be recommended for routine clinical use, however, incorporating apoB and apoB:apoA-I into risk assessment could provide additional important information on cardiovascular risk.

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Evaluation of the Acutely Dyspneic Elderly Patient

Cited by 48 publications

References 33 publications

MicroRNAs Expression Profiles in Cardiovascular Diseases

MicroRNAs Expression Profiles in Cardiovascular Diseases

An Association between air quality and COPD in Ahvaz, Iran

How Do Apolipoproteins ApoB and ApoA-I Perform in Patients with Acute Coronary Syndromes

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