Evaluation of the adverse effects of long-term hyposensitization

Circulating immune complexes in bronchial asthma

“…Our observation that IC were frequently detected in patients treated by immunotherapy agree with the findings by Cano et al, (1977) and Raphael et al (1976) who have investigated patients with allergic rhinitis. However, discordant results have been published by Levinson et al (1978) and Stein et al, (1978). These discrepancies may result from different selections of the patients or more likely from methodological differences.…”

Hyposensitization in Asthma: A review

“…Asthma, rhinitis and urticaria were the most frequent reactions, whilst anaphylactic shock occurred in two patients; neither was fatal and responded to treatment with adrenalin (Vervloet et al 1980). It has been suggested that hyposensitization may cause late sequelae such as autoimmune disease or Iymphoproliferative disorder, but a recent study showed no increase in such problems (Levinson et al 1978). Occasionally, worsening of allergic disease has been associated with courses of hyposensitization, but it is impossible to determine whether this would have occurred even without such treatment.…”

Long-term health effects of repeated exposure to multiple vaccines

“…Reports of plasma cell dyscrasias [32][33][34] and vasculitis [35] after prolonged administration of allergens to promote allergic hyposensitization suggest that prolonged stimulation of the reticuloendothelial system may promote aberrant immune system behaviors in some humans. Such complications are apparently infrequent, however, as supported by failure to identify similar phenomena among populations of atopic patients receiving long-term hyposensitization therapy in allergy clinics [4,5].…”

“…examined, and to date, little in the way of long-term adverse health consequences have been documented [4,5]. Similar studies to determine the impact of repeated vaccination against bacterial, viral, or fungal pathogens have been infrequently performed.…”