Evaluation of the anti-inflammatory and analgesic properties of the extract of Russelia equisetiformis (Schlecht &amp; Cham) Scrophulariacae

Awe, Emmanuel O.; Makinde, J. M.; Olajide, Olumayokun A.; Wakeel, Olayemi Kamoru

doi:10.1163/1568560043696245

Cited by 7 publications

(6 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The plants were selected based on the availability of plant materials and because of the many significant studies on their medicinal uses, such as anti-inflammatory, anti-diabetic, anti-hypertensive, anti-cancer and anti-viral properties [6,7,8,9,10,]; and removal of pollutants from wetlands [11,12] These plants have rich histories of medicinal value. Research demonstrates the anti-diabetic activity of CA [6,23,29] and anti-inflammatory activity of RE [8]. CO has a history of use for its' anti-inflammatory and anti-cancer properties [13].…”

Section: Introductionmentioning

confidence: 99%

Comparative Assessment Of Total Phenolic Content In Selected Medicinal Plants

Johnson¹,

Oladeinde²,

Kinyua³

et al. 2009

Nigerian Journal of Natural Products and Medicine

View full text Add to dashboard Cite

This study was to compare the total phenolic (TP) content in extracts from eleven plant materials collected at different geographical locations in Kenya, Nigeria, and USA. These plants have been selected because the majority of them are highly pigmented, from yellow to purple, and would therefore have economic value in industries for producing antioxidants and surfactants. Two of them were collected from the industrial and domestic waste outlets. Each analysis was achieved using the Folin-Ciocalteau technique. The order of decreasing phenolic acid content as gallic acid concentration (mg/g dry weight) was Prunus africana (55.14) > Acacia tortilis (42.11) > Khaya grandifoliola (17.54) > Curcuma longa (17.23) > Vernonia amygdalina (14.9)> Russelia equisetiformis (14.03) > Calendula officinalis (7.96) >Phragmites australis (control) (7.09) > Rauwolfia vomitoria (6.69) > Phragmites australis (industrial) (6.21) > Cnidoscolus aconitifolius (5.6). The TP contents of Spartina alterniflora species were below the detection limit.

show abstract

Section: Introductionmentioning

confidence: 99%

Comparative Assessment Of Total Phenolic Content In Selected Medicinal Plants

Johnson¹,

Oladeinde²,

Kinyua³

et al. 2009

Nigerian Journal of Natural Products and Medicine

View full text Add to dashboard Cite

show abstract

“…Medicinally, the plant is used for the treatment of diabetes and leukemia in Southwestern, Nigeria[ 10 ]. The extract of the plant has been reported to possess antibacterial, analgesic and antiinflammatory activities[ 11 ]. Recently, two flavonoid compounds isolated from R. equisetiformis were reported to have potential analgesic activity[ 12 ].…”

mentioning

confidence: 99%

In vivo antimalarial activities of russelia equisetiformis in plasmodium berghei infected mice

Ojurongbe¹,

Ojo²,

Adefokun³

et al. 2015

Indian J Pharm Sci

View full text Add to dashboard Cite

The rising problem of resistance to most commonly used antimalarials remains a major challenge in the control of malaria suggesting the need for new antimalarial agents. This work explores the antiplasmodial potential of ethanol extract of Russelia equisetiformis in chloroquine Plasmodium berghei infected mice. Swiss albino mice were intraperitoneally infected with chloroquine-resistant P. berghei (ANKA). Experimental mice were treated for four days consecutively with graded doses of plant extracts and standard antimalarial drugs (artesunate and chloroquine) at a dose of 10 mg/kg body weight used as control. The extract showed a dose-dependent activity in the chemosuppression of P. berghei parasites by 31.6, 44.7, 48.4 and 86.5% at doses of 100, 200, 400 and 800 mg/kg, while chloroquine (10 mg/kg) and artesunate produced 59.4 and 68.4%, respectively. The extract showed a significant decrease in parasitaemia (P<0.05). The level of parasitemia and decrease in weight in all the treated groups was significantly lower (P<0.05) compared with the infected but untreated mice. The plant extract was devoid of toxicity at the highest dose tested (5000 mg/kg). The study concluded that the ethanol extract of R. equisetiformis possesses antimalarial effect, which supports the folk medicine claim of its use in the treatment of malaria.

show abstract

“…In Colombia, the fresh entire plant decoction is taken orally to cure kidney stones 7 , while the whole plant and its aerial infusion is utilized as a complementary therapy for DM2 patients in Mexico [8][9] . An anti-oxidant, anti-inflammatory 6 , antinociceptive and analgesic properties [10][11] were observed for different extracts of R. equisetiformis, together with antibacterial 12 , antimicrobial, cytotoxic 13 , CNS depressant 14 , hepatic functions activity 5 , hair growth promoter 15 and membrane stabilizing activities 16 . The present study reported the separation and structure elucidation of eight compounds (Fig 1) from different fractions of the aerial parts of R. equisetiformis, in addition to evaluate the LD50, antiinflammatory, antipyretic and antihyperglycemic activities of it.…”

Section: Introductionmentioning

confidence: 99%