Evaluation of the anti-inflammatory properties of Dodonaea polyandra, a Kaanju traditional medicine

Simpson, Bradley S.; Claudie, David; Smith, Nick M.; Wang, Jiping; McKinnon, Ross A.; Semple, Susan J.

doi:10.1016/j.jep.2010.07.012

Cited by 31 publications

(31 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prenylflavonoids extracted from crude leaf of D. polyandra could inhibit an acute inflammatory response in vivo model with TPA-induced mouse ear edema (Simpson et al, 2010). Lipopolysaccharide-induced cytokine production of monocyte chemo-attractant protein-1 (MCP-1) was inhibited by xanthohumol and isoxanthohumol with IC 50 values of 14.4 mM and 12.6 mM, respectively, indicating that the position, number and length of the prenyl group had a marked influence on suppression of MCP-1 production (Jones et al, 1996;Peluso et al, 2010).…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

A systematic review on biological activities of prenylated flavonoids

Chen

Mukwaya

Wong

et al. 2013

Pharmaceutical Biology

198

136

View full text Add to dashboard Cite

Context: Prenylated flavonoids are a unique class of naturally occurring flavonoids that exist especially for the plant's self-defensive strategy. This special class of flavonoids increases the bioactivities of their backbone flavonoids with non-prenylation; therefore, prenylated flavonoids have more potential to be developed and utilized. Objective: The number, position and type of the prenyl group on the flavonoids backbone structure may have close relationships with the bioactivities of flavonoids. Methods: PubMed and WEB OF KNOWLEDGEÕ were used to search articles published in English between 1 January 2002 and 31 December 2012, which discuss the structure-activity relationship between prenylated flavonoids and their bioactivities. Results: It is proposed that the prenyl-moiety makes the backbone compound more lipophilic, which leads to its high affinity with cell membranes. The prenylation brings the flavonoids with enhancement of antibacterial, anti-inflammatory, antioxidant, cytotoxicity, larvicidal as well as estrogenic activities. However, it is reported that the prenyl-moiety decreases the bioavailability and plasma absorption of prenylated flavonoids. Conclusion: The prenyl group affects the bioactivities of flavonoids in certain ways, while the action mechanisms and the structure-activity relationship as well as more in vivo studies even clinical validation trials need to be further investigated.

show abstract

Section: Anti-inflammatory Activitymentioning

confidence: 99%

A systematic review on biological activities of prenylated flavonoids

Chen

Mukwaya

Wong

et al. 2013

Pharmaceutical Biology

198

136

View full text Add to dashboard Cite

show abstract

“…We have previously investigated several plant species for anti-inflammatory activities [25, 28] as Kuuku I’yu Traditional Owners have used these plants for treating diseases associated with inflammation [29]. Traditional medicinal plants previously shown to have anti-inflammatory properties have also been reported to exhibit blood-glucose-lowering and antiglycation effects [30–33].…”

Section: Introductionmentioning

confidence: 99%

In vitro inhibitory activities of selected Australian medicinal plant extracts against protein glycation, angiotensin converting enzyme (ACE) and digestive enzymes linked to type II diabetes

Deo

Hewawasam

Karakoulakis

et al. 2016

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundThere is a need to develop potential new therapies for the management of diabetes and hypertension. Australian medicinal plants collected from the Kuuku I’yu (Northern Kaanju) homelands, Cape York Peninsula, Queensland, Australia were investigated to determine their therapeutic potential. Extracts were tested for inhibition of protein glycation and key enzymes relevant to the management of hyperglycaemia and hypertension. The inhibitory activities were further correlated with the antioxidant activities.MethodsExtracts of five selected plant species were investigated: Petalostigma pubescens, Petalostigma banksii, Memecylon pauciflorum, Millettia pinnata and Grewia mesomischa. Enzyme inhibitory activity of the plant extracts was assessed against α-amylase, α-glucosidase and angiotensin converting enzyme (ACE). Antiglycation activity was determined using glucose-induced protein glycation models and formation of protein-bound fluorescent advanced glycation endproducts (AGEs). Antioxidant activity was determined by measuring the scavenging effect of plant extracts against 1, 1-diphenyl-2-picryl hydrazyl (DPPH) and using the ferric reducing anti-oxidant potential assay (FRAP). Total phenolic and flavonoid contents were also determined.ResultsExtracts of the leaves of Petalostigma banksii and P. pubescens showed the strongest inhibition of α-amylase with IC50 values of 166.50 ± 5.50 μg/mL and 160.20 ± 27.92 μg/mL, respectively. The P. pubescens leaf extract was also the strongest inhibitor of α-glucosidase with an IC50 of 167.83 ± 23.82 μg/mL. Testing for the antiglycation potential of the extracts, measured as inhibition of formation of protein-bound fluorescent AGEs, showed that P. banksii root and fruit extracts had IC50 values of 34.49 ± 4.31 μg/mL and 47.72 ± 1.65 μg/mL, respectively, which were significantly lower (p < 0.05) than other extracts. The inhibitory effect on α-amylase, α-glucosidase and the antiglycation potential of the extracts did not correlate with the total phenolic, total flavonoid, FRAP or DPPH. For ACE inhibition, IC50 values ranged between 266.27 ± 6.91 to 695.17 ± 15.38 μg/mL.ConclusionsThe tested Australian medicinal plant extracts inhibit glucose-induced fluorescent AGEs, α-amylase, α-glucosidase and ACE with extracts of Petalostigma species showing the most promising activity. These medicinal plants could potentially be further developed as therapeutic agents in the treatment of hyperglycaemia and hypertension.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1421-5) contains supplementary material, which is available to authorized users.

show abstract

“…Several extracts from leaves of Dodonaea polyandra showed significant anti-inflammatory potential using the mouse ear edema model of acute inflammation induced by croton oil and TPA-12-o-tetradecanoylphorbol-13-acetate PMA-phorbol 12-myristate 13-acetate (TPA). The significant inhibitory effects of the extracts tested suggest that the prostaglandin pathway of the inflammation process may be a potential target of the active component [30]. Chloroform extract obtained from Albizia chinensis has shown reduction in the ulcer index (p<0.001) when compared to control and positive control [31].…”

Section: Fig 2: Structures Of Compounds Having Anti-inflammatory Potmentioning

confidence: 99%

Terpenoids as Source of Anti-Inflammatory Compounds

Prakash

2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Terpenoids accounts for the major class of secondary metabolites produced by plants. It shows defense activity against environmental stress and help to heal injuries. Medicinal plants are rich in monoterpenoids, diterpenoids, sesquiterpenes, triterpenes, tetraterpenes, and ceramide. A number of therapeutic applications such as antibacterial, antimicrobial, antitumor, anti-inflammatory activity have been identified. Terpenoids are compounds similar to terpenes derived from 5-carbon monomer isoprene units. The review puts and detail insight on different class of compounds isolated from natural source from 2000 to 2016 showing anti-inflammatory potential of pharmacologically interesting agent and their mechanism of action.

show abstract

Evaluation of the anti-inflammatory properties of Dodonaea polyandra, a Kaanju traditional medicine

Cited by 31 publications

References 10 publications

A systematic review on biological activities of prenylated flavonoids

A systematic review on biological activities of prenylated flavonoids

In vitro inhibitory activities of selected Australian medicinal plant extracts against protein glycation, angiotensin converting enzyme (ACE) and digestive enzymes linked to type II diabetes

Terpenoids as Source of Anti-Inflammatory Compounds

Contact Info

Product

Resources

About