Evaluation of the antiapoptotic and anti-inflammatory properties of chitosan in methotrexate-induced oral mucositis in rats

Bilginaylar, Kani; Aykaç, Aslı; Sayıner, Serkan; Özkayalar, Hanife; Şehirli, Ahmet Özer

doi:10.1007/s11033-022-07158-x

Cited by 14 publications

(11 citation statements)

References 45 publications

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“…High levels of these gelatinases in the bloodstream are linked to an in ammatory process (49). MMPs have been associated with the pathophysiology of the MTX (50). In current study, we demonstrated that serum MMP-2 and MMP-9 levels increased after MTX administration in consistent with the literature.…”

Section: Discussionsupporting

confidence: 91%

Hepatoprotective effect of morin against methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways

Kızıl

Çağlayan

Darendelioğlu

et al. 2022

Preprint

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Background Organ toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-metabolite therapeutic that is frequently used as an anti-cancer and immunosuppressive medicine. Hepatocellular toxicity is among the most severe side effects of long-term MTX use. The present study unveils new confirmations as regards the remedial effects of morin on MTX-induced hepatocellular injury through regulation of oxidative stress, apoptosis and MAPK signaling. Methods Rats were subjected to oral treatment of morin (50 and 100 mg/kg body weight) for 10 days. Hepatotoxicity was induced by single intraperitoneal injection of MTX (20 mg/kg body weight) on the 5th day. Results MTX related hepatic injury was associated with increased MDA while decreased GSH levels, the activities of endogen antioxidants (glutathione peroxidase, superoxide dismutase and catalase) and mRNA levels of HO-1 and Nrf2 in the hepatic tissue. MTX treatment also resulted in apoptosis in the liver tissue via increasing mRNA transcript levels of Bax, caspase-3, Apaf-1 and downregulation of Bcl-2. Conversely, treatment with morin at different doses (50 and 100 mg/kg) considerably mitigated MTX-induced oxidative stress and apoptosis in the liver tissue. Morin also mitigated MTX-induced increases of ALT, ALP and AST levels, downregulated mRNA expressions of matrix metalloproteinases (MMP-2 and MMP-9), MAPK14 and MAPK15, JNK, Akt2 and FOXO1 genes. Conclusions According to the findings of this study, morin may be a potential way to shield the liver tissue from the oxidative damage and apoptosis.

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Section: Discussionsupporting

confidence: 91%

Hepatoprotective effect of morin against methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways

Kızıl

Çağlayan

Darendelioğlu

et al. 2022

Preprint

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“…CT supplementation repressed the expression of NF-kB and p53, suggesting its potential anti-inflammatory and anti-apoptotic effects. These findings agree with separate studies by Zou et al (2019) and Bilginaylar et al (2022), which implicated the inhibition of NF-kB and p53 in the beneficial effects of CT.…”

Section: Nfs 533supporting

confidence: 93%

Effect of chitosan on cardio-metabolic risk factors induced by high fat diet in rats

Ugbaja

Onunkwor

Ugwor

et al. 2022

NFS

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Purpose This study aims to scrutinize the efficacy of chitosan (CT) on cardio-lipotoxic responses elicited by a high-fat diet (HF). Design/methodology/approach Thirty-six male Wistar rats were distributed across six groups (n = 6): normal diet (ND), HF, ND-5%CT, HF-1%CT, HF-3%CT and HF-5%CT, for seven weeks. Blood and cardiac tissues were processed for biochemical, immunohistochemical and histopathological analyses. Findings Ingestion of HF induced hyperlipidaemia and lipid accumulation, leading to increased body and heart weight by 70.5% (p < 0.0001) and 124% (p = 0.0021), respectively, compared to ND-groups. Cardiac damage markers (creatine kinase, lactate dehydrogenase and malondialdehyde) were higher in the HF-group compared to control rats. Also, atherogenic and coronary risk indices were significantly elevated by 155% (p = 0.0044) and 174% (p = 0.0008), respectively, compared to control rats. Rats fed HF had significantly reduced cardiac antioxidants (superoxide dismutase, catalase and glutathione peroxidase) and elevated expression of NF-κB-p65 and p53 (p < 0.0001) in the cardiac tissues. Histology revealed lipid inclusions in the cardiac tissues of HF-groups. CT (1%–5%) prevented hyperlipidaemia, lipid accumulation, oxidative stress and cardiac damage in HF-fed rats, while greatly improving the histology of the cardiac tissues in HF-fed rats in a dose-dependent manner. Originality/value To the best of the authors’ knowledge, this is the first report of the effects of CT against cardio-lipotoxicity elicited by HF diet ingestion. The findings suggest that CT may present a safe therapeutic alternative for managing complications arising from cardio-lipotoxicity.

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“…It exhibits good biocompatibility, biodegradability, adhesiveness, and sustained drug release properties [ 18 ]. This work found that chitosan has a protective effect on methotrexate (MTX)-induced oral mucosal damage, and it may be a promising candidate drug for mitigating MTX-induced oral mucositis [ 19 ]. CS/DOPE nanohydrogel can encapsulate baicalein within its structure, resulting in CS/DOPE-BAE nanohydrogel, which enhances the solubility, stability, and bioavailability of baicalein.…”

Section: Introductionmentioning

confidence: 99%

Effect of chitosan/dioleyl phosphatidyl ethanolamine - Baicalein nanohydrogel in the treatment of rat with periodontitis

Guo,

Han,

Zhang

et al. 2024

Heliyon

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Evaluation of the antiapoptotic and anti-inflammatory properties of chitosan in methotrexate-induced oral mucositis in rats

Cited by 14 publications

References 45 publications

Hepatoprotective effect of morin against methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways

Hepatoprotective effect of morin against methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways

Effect of chitosan on cardio-metabolic risk factors induced by high fat diet in rats

Effect of chitosan/dioleyl phosphatidyl ethanolamine - Baicalein nanohydrogel in the treatment of rat with periodontitis

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