Evaluation of the antibacterial activity of some doped phosphocalcic glasses with silver and copper

Abstract

Doping of calcium phosphate glasses from the ternary system SiO2-CaO-P2O5, with transition metals ions makes them to acquire additional properties, of a prophylactic nature (anti-inflammatory, healing, antimicrobial). This paper presents the microbiological study performed of three glass compositions synthesized by sol-gel method, one doped with silver, the other doped with copper II, compared to a control sample, with the same compositional matrix, but not doped, in order to highlight their antimicrobial character and the determination of the minimum bactericidal dose of each type of glass on two strains of bacteria with high pathogenic potential.

Novel Developments in Advanced Materials Fields: Porous and Non-Porous Biomaterials Used in Regenerative Medicine and Tissue Engineering

“…al. [24] made by the sol-gel method three different types of calcium phosphate glasses from ternary system SiO2-CaO-P2O2: the reference sample P (Fig. 6 a) not doped with metals, which is the basic composition, (Table 1 ), the second sample, PA type is doped with silver (Fig.…”

“…6 b) and the third sample PC, is doped with copper (Fig. 6 c) [24]. They determined the minimum bactericidal dose of each type of glass on two strains of bacteria with high pathogenic potential.…”

“…Table 1. The composition of the three types of phosphocalcic glass [24] They concluded that bioglasses doped with silver (PA sample) have a more effective antimicrobial activity than those doped with copper (PC), but in the long term, during the exploitation period of the implant, which can last from a few weeks to a few years, this difference in the microbial activity of the two compared samples becomes insignificant.…”

“…Porous structures with interconnected porosity or open cells allow the transport of body fluid respectively the growth and regeneration of bone in the pore areas, and thus a viscoelastic biomaterial with a remarkable regeneration capacity is obtained [20]. By developing the porous scaffolds, it is necessary to have some essential requirements (characteristics) [21][22][23][24][25][26], briefly presented below in the Figure 1.…”