Evaluation of the Antibacterial Effects of Single and Combined use of Different Irrigation Solutions Against Intracanal Enterococcus Faecalis

Özkan, Hatice Büyüközer; Çobankara, Funda Kont; Sayın, Zafer; Özer, Füsun

doi:10.15644/asc54/3/3

Cited by 10 publications

(8 citation statements)

References 40 publications

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“…Micro-CT studies have shown that in round canals, between 10% and 50% of their total area remains unprepared [40]. When using instrumentation on the root canal system, approximately 30% of the endodontic space remains unprepared [41,42]. Such spaces may contain residual pulp or bacterial biofilm in infected canals, thus exerting adverse effects on treatment outcomes [43].…”

Section: Discussionmentioning

confidence: 99%

Micro-computed tomography (micro-CT) evaluation of root canal morphology in immature maxillary third molars

2024

JOCPD

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The endodontic treatment of immature permanent teeth with necrotic pulp is a significant clinical challenge. The success of regenerative endodontic procedure is highly dependent on disinfection of the root canal and an accurate anatomical knowledge of the root canal. The aim of this study was to use micro-computed tomography (micro-CT) analysis to investigate the configuration of root canals in the upper permanent third maxillary molars with incomplete root development in their coronal, apical and middle third portions. Thirty immature third permanent maxillary molars were scanned using a micro-CT system. Then, we measured the diameters and areas of the root canal in the coronal, middle and apical third of the roots. The ratio between the long and short diameter of each root canal was then calculated and the canals were divided into several groups: round, oval, long oval, flat and irregular. The round configuration was not observed in the distobuccal and mesiobuccal roots in any of their anatomical regions. Oval and long oval canals predominated in the distobuccal root. The greatest variations were observed in the mesiobuccal root, with the ribbon-shaped canal predominating in the middle region and an irregular shape in the apical region. In the coronal region of the palatal canal, the round configuration predominated; in the middle third, we observed an almost equivalent distribution between round and oval configurations; apically, the oval shape predominated. In conclusion, we observed significant complexity and variation in the morphology and configuration of root canals in immature permanent molars, thus generating additional obstacles for the success of regenerative endodontics.

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Section: Discussionmentioning

confidence: 99%

Micro-computed tomography (micro-CT) evaluation of root canal morphology in immature maxillary third molars

2024

JOCPD

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“…In order to make comparison and meta-analysis more effective for past and future studies, human single-rooted teeth were preferred in our study. In addition, wide and straight canals in this type of single-rooted teeth enable irrigation solution application research and activation efficiency research to be carried out in laboratory environments in a more standardized manner [ 8 , 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Sodium hypochlorite (NaOCl) is currently the most widely used irrigation solution, especially due to its solvent effect on pulp tissue, high antibacterial activity, and lubricating properties [ 8 ]; however, its cytotoxicity at high concentrations and inadequacy in removing the smear layer alone have led to research into alternative solutions [ 8 ]. For this purpose, solutions such as boric acid (BA), chlorine dioxide (ClO 2 ), and hypochlorous acid (HOCl) continue to be evaluated for their potential as irrigation solutions due to their different properties [ 8 – 10 ]. Additionally, due to its inadequacy in removing the smear layer alone, it is necessary to use two or more irrigation solutions sequentially.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of surface tensions and root-dentin surface contact angles of different endodontic irrigation solutions

Buyukozer Ozkan,

Terlemez,

Batibay

et al. 2024

BMC Oral Health

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Background Surface tension and contact angle properties, which play a crucial role in determining the effectiveness of irrigation solutions in penetrating dentin surfaces and dentin tubules, are highly important for the development of new irrigation solutions and their preferences. The aim of the current study was to compare the surface tension and contact angle properties of different irrigation solutions used in endodontics, both on the dentin surface and within dentin tubules. Methods In this study, the contact angles and surface tensions of 5.25% sodium hypochlorite (NaOCl), 17% ethylenediaminetetraacetic acid (EDTA), 2% chlorhexidine (CHX), 5% boric acid (BA), 0.02% hypochlorous acid (HOCl), 0.2% chlorine dioxide (ClO2), Biopure MTAD, QMix solutions, and distilled water (control group) were measured. Measurements were conducted using a goniometer device (Attension Theta Lite Tensiometer, Biolin Scientific, USA), employing the sessile drop method for contact angle measurements on pre-prepared dentin surfaces, and the pendant drop method for surface tension. Results Contact angle measurements revealed no statistically significant differences between the contact angle values of MTAD, ClO2, and CHX or between NaOCl, QMix, BA, and HOCl (p > 0.05). However, EDTA exhibited a significantly greater contact angle than did MTAD, ClO2, CHX, NaOCl, QMix, BA, and HOCl (p < 0.05). Furthermore, the contact angle of dentin with distilled water was greater than that with all other solutions tested (p < 0.05). Surface tension measurements revealed that the surface tension values of QMix and MTAD were statistically similar (p > 0.05). CHX exhibited lower surface tension than distilled water and HOCl (p < 0.05), and it also had lower surface tension than ClO2, NaOCl, and BA (p < 0.05). Additionally, the surface tension of the samples treated with EDTA was greater than that of all other solutions tested (p < 0.05). Conclusion The direct linear relationship between the surface tension of liquids and contact angles on different surfaces may not always hold true, and these values should be considered independently for each solution on various surfaces. Considering the contact angles and surface tension properties of irrigation solutions with root canal dentin, it can be suggested for clinical use that ClO2 could be recommended over NaOCl, and similarly, BA could be recommended over EDTA.

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“…Some studies have found that these regions in the root canal system are left untouched during mechanical instrumentation [3][4][5][6], which makes the goal of endodontic therapy unlikely to be achieved with mechanical instrumentation alone. As a result, chemical irrigants are essential for disinfecting these complicated root canal anatomies [7]. An ideal irrigant should have strong antibacterial properties, dissolve any remaining pulp tissues without posing systemic health risks, and be readily available [8].…”

Section: Introductionmentioning

confidence: 99%

Effect of Addition of Cetylpyridinium Chloride Cationic Surfactant on the Antimicrobial Activity of Chlorhexidine Endodontic Irrigant

Al-Sada,

Al-Gharrawi

2024

International Journal of Dentistry

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Background. Endodontic irrigants are essential for disinfecting the root canal system. None of the currently available irrigants perfume sufficiently. However, most products contain surfactants, which enhance the antimicrobial properties of the irrigants. Objectives. To evaluate the effect of cetylpyridinium chloride (CPC) surfactant on the antimicrobial activity of chlorhexidine and compare it with that of chlorhexidine (CHX) and Biopure MTAD against Enterococcus faecalis, Staphylococcus aureus, and Candida albicans. Materials and Methods. In this in vitro study, three microorganisms were used (E. faecalis, S. aureus, and C. albicans), and each organism was treated with three different irrigants: 2% CHX, 2% CHX + 0.2% CPC, and 100% Biopure MTAD. The antimicrobial activity was evaluated by direct contact assay for 5 min of contact time. The colony-forming unit per mL was calculated after antimicrobial treatment and 24 hr of incubation at 37°C. The data were statistically analyzed using Statistical Package for Social Science (SPSS) version 22. The Kruskal–Wallis and the multiple Wilcoxon sum rank tests were used. The level of significance was set at 0.05. Results. The result showed a nonsignificant difference between the different irrigants against E. faecalis. Among S. aureus subgroups, 2% CHX was statistically significant and more efficient than MTAD. Among C. albicans subgroups, 2% CHX and combined irrigant (2% CHX + 0.2% CPC) were statistically more efficient than MTAD. The 2% CHX and combined irrigants were equally effective against all the tested microorganisms. Conclusions. All the used irrigants have comparable effects against E. faecalis after 5 min. CHX have a comparable effects to that of the combined irrigant and more efficient against S. aureus than MTAD. CHX and the combined irrigant have potent antimicrobial activity against C. albicans superior to MTAD. CPC surfactant can be used with CHX to overcome its clinical drawbacks or limitations without altering or reducing its antimicrobial activity.

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Evaluation of the Antibacterial Effects of Single and Combined use of Different Irrigation Solutions Against Intracanal Enterococcus Faecalis

Cited by 10 publications

References 40 publications

Micro-computed tomography (micro-CT) evaluation of root canal morphology in immature maxillary third molars

Micro-computed tomography (micro-CT) evaluation of root canal morphology in immature maxillary third molars

Evaluation of surface tensions and root-dentin surface contact angles of different endodontic irrigation solutions

Effect of Addition of Cetylpyridinium Chloride Cationic Surfactant on the Antimicrobial Activity of Chlorhexidine Endodontic Irrigant

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