Evaluation of the Antibacterial efficacy of newly formulated Nano Triple Antibiotic paste with Nano Anti-inflammatory drug as a root canal medicament. (A double blind randomized clinical trial)

Nashaat, Yousra M.

doi:10.21608/edj.2020.41856.1245

Egyptian Dental Journal

2020

DOI: 10.21608/edj.2020.41856.1245

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Evaluation of the Antibacterial efficacy of newly formulated Nano Triple Antibiotic paste with Nano Anti-inflammatory drug as a root canal medicament. (A double blind randomized clinical trial)

Yousra M. Nashaat

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Cited by 2 publications

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Comparison of the Antibacterial Efficacy of Ibuprofen Versus Triple Antibiotic Paste Against Enterococcus Faecalis in Single Rooted Teeth

Rezk

El-Baz

Naeem

2021

Egyptian Dental Journal

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Aim:The aim of the present study was to compare the antibacterial efficiency of the antiinflammatory non-antibiotic ibuprofen versus triple antibiotic paste as an intra-canal medication against Enterococcus faecalis. Methodology: Forty four single rooted teeth were decoronated and instrumented up to F4 ProTaper rotary files. Apical foramen was sealed with acrylic resin, and all the external surfaces were made impermeable with nail varnish, except for the coronal access. Roots were autoclaved at 121°C for 20 minutes, placed in Eppendorf tubes and contaminated with E. faecalis for 14 days. Teeth were divided into two groups of 22 teeth; (Group1: ibuprofen, Group2: triple antibiotic paste (TAP). Colony forming unit (CFU) counts were taken before placing the intracanal medications by a paper point sampling (CFU1). The tested medicaments were mixed with distilled water (1:1 w/v), placed inside the root canals, then canals were temporarily sealed, and incubated at 37°C for 7 days. After intracanal medication removal, the second count (CFU2) was taken as (CFU1) and the antibacterial action of each medication was determined by calculating the percentage of bacterial reduction when comparing CFU2 to CFU1, and then the antibacterial action of the tested medications was compared with each other.Results: There was no statistically significant difference between (T.A.P) and (Ibuprofen) groups in the percentage of bacterial reduction where (p=0.073). Both medications caused a reduction in the bacterial count from CFU1 to CFU2. Conclusion:Ibuprofen proved to have an antibacterial effect comparable to that of TAP.

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Comparison of the Antibacterial Efficacy of Ibuprofen Versus Triple Antibiotic Paste Against Enterococcus Faecalis in Single Rooted Teeth

Rezk

El-Baz

Naeem

2021

Egyptian Dental Journal

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Evaluation of the antibacterial efficacy of nanomodified triple antibiotic paste with nano anti-inflammatory drug and nano calcium hydroxide as intracanal medicament using confocal laser scanning microscope

Prakhyath,

Parvathaneni,

Raju

et al. 2024

Endodontology

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Aim: To evaluate and compare the antibacterial efficacy of Nano amoxicillin modified Triple antibiotic paste (mTAP) with nano Ibuprofen and nano calcium hydroxide (Ca(OH)2) as a root canal medicament on Enterococcus faecalis infected root canal dentin.. Methods: Sixty eight semi-cylindrical root samples were infected for 3 weeks with E. faecalis ATCC 29212 and randomly assigned into 4 Groups based on the medication used, Ca(OH)2; Nano Ca(OH)2; Amoxicillin mTAP +I (Ibuprofen); Nano Amoxicillin mTAP + Nano Ibuprofen and was incubated for 7 days. The proportions of dead and live bacteria was quantitatively analyzed by Confocal laser scanning microscopy. One-way ANOVA was used to compare the four groups and intergroup comparison with Tukey’s post hoc tests. Results: Nano Amoxicillin mTAP with Nano Ibuprofen was shown to have a higher antibacterial effect against E. faecalis compared to the unmodified medicaments. Conclusion: Nanomodified ICMs of APIs showed better antimicrobial activity due to their increased stability and deeper penetration into dentinal tubules when compared to conventional forms of ICMs.

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Evaluation of the Antibacterial efficacy of newly formulated Nano Triple Antibiotic paste with Nano Anti-inflammatory drug as a root canal medicament. (A double blind randomized clinical trial)

Cited by 2 publications

References 24 publications

Comparison of the Antibacterial Efficacy of Ibuprofen Versus Triple Antibiotic Paste Against Enterococcus Faecalis in Single Rooted Teeth

Comparison of the Antibacterial Efficacy of Ibuprofen Versus Triple Antibiotic Paste Against Enterococcus Faecalis in Single Rooted Teeth

Evaluation of the antibacterial efficacy of nanomodified triple antibiotic paste with nano anti-inflammatory drug and nano calcium hydroxide as intracanal medicament using confocal laser scanning microscope

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