2008
DOI: 10.1016/j.pnpbp.2008.04.005
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Evaluation of the antibradykinetic actions of 5-HT1A agonists using the mouse pole test

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Cited by 34 publications
(28 citation statements)
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“…1,[3][4][5] Several studies demonstrated that activation of 5-HT 1A receptors improves antipsychotic-induced EPS and motor disabilities in animal models of Parkinson's disease. [10][11][12][13][14][15][16] In our studies, 5-HT 1A agonists (e.g., 8-hydroxy-2-(di-n-propylamino)-tetralin and tandospirone) ameliorated haloperidol-induced bradykinesia and catalepsy with potencies similar to those of antiparkisonian agents (e.g., trihexyphenidyl and L-3,4-dihydroxyphenylalanine (L-DOPA)). 13,14) Consistently with these anti-EPS actions, 5-HT 1A agonists reversed striatal Fos protein expression induced by haloperidol, indicating that 5-HT 1A receptors counteract D 2 receptor blockade by antipsychotics in the striatum.…”
Section: Roles Of 5-ht Receptors In Modulating Extrapyramidal Motor Dmentioning
confidence: 56%
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“…1,[3][4][5] Several studies demonstrated that activation of 5-HT 1A receptors improves antipsychotic-induced EPS and motor disabilities in animal models of Parkinson's disease. [10][11][12][13][14][15][16] In our studies, 5-HT 1A agonists (e.g., 8-hydroxy-2-(di-n-propylamino)-tetralin and tandospirone) ameliorated haloperidol-induced bradykinesia and catalepsy with potencies similar to those of antiparkisonian agents (e.g., trihexyphenidyl and L-3,4-dihydroxyphenylalanine (L-DOPA)). 13,14) Consistently with these anti-EPS actions, 5-HT 1A agonists reversed striatal Fos protein expression induced by haloperidol, indicating that 5-HT 1A receptors counteract D 2 receptor blockade by antipsychotics in the striatum.…”
Section: Roles Of 5-ht Receptors In Modulating Extrapyramidal Motor Dmentioning
confidence: 56%
“…[10][11][12][13][14][15][16] In our studies, 5-HT 1A agonists (e.g., 8-hydroxy-2-(di-n-propylamino)-tetralin and tandospirone) ameliorated haloperidol-induced bradykinesia and catalepsy with potencies similar to those of antiparkisonian agents (e.g., trihexyphenidyl and L-3,4-dihydroxyphenylalanine (L-DOPA)). 13,14) Consistently with these anti-EPS actions, 5-HT 1A agonists reversed striatal Fos protein expression induced by haloperidol, indicating that 5-HT 1A receptors counteract D 2 receptor blockade by antipsychotics in the striatum. 14,15) Earlier studies showed that microinjection of 5-HT 1A agonists into the raphe nuclei attenuated antipsychotic-induced catalepsy, suggesting that activation of presynaptic 5-HT 1A autoreceptors can reduce EPS 11) ( Fig.…”
Section: Roles Of 5-ht Receptors In Modulating Extrapyramidal Motor Dmentioning
confidence: 73%
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“…It is therefore conceivable that, besides 5-HT 2A antagonism, 5-HT 1A agonism also alleviates APDinduced EPS and/or Parkinson's disease (3). Although the mechanisms for these actions of 5-HT 1A agonists are yet to be clarified, we have previously shown that alleviation of haloperidol-induced EPS by 8-OH-DPAT was resistant against the serotonergic denervation with p-chlorophenylalanine (a 5-HT synthetase inhibitor) (8). Consistent with previous findings (4,7,9), our results suggest that 8-OH-DPAT alleviates APD-induced EPS probably through activating postsynaptic 5-HT 1A receptors (including heteroreceptors).…”
Section: Introductionmentioning
confidence: 99%
“…Several lines of evidence have shown that 5-HT1A receptors play an important role in controlling motor functions and ameliorate various extrapyramidal disorders such as PD (5)(6)(7)(8)(9) and L-DOPA-induced motor disabilities (10)(11)(12)(13). In addition, 5-HT1A receptors are implicated in the pathogenesis and treatment of mood disorders (anxiety/ depression) (8).…”
Section: Introductionmentioning
confidence: 99%