Evaluation of the Antidiabetic and Antihyperlipidemic Activity of Spondias purpurea Seeds in a Diabetic Zebrafish Model

Muñiz-Ramírez, Alethia; Campoy, Abraham Heriberto García; Gutierrez, Rosa Martha Pérez; Baez, Efrén Venancio García; Flores, José María Mota

doi:10.3390/plants10071417

Cited by 6 publications

(2 citation statements)

References 67 publications

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“…The increase in glycaemia caused by the injection of alloxan into zebrafish was reduced following the administration of 3g/kg of Psychotria malayana extract, proving its hypoglycemic property [20]. Similarly, according to Muñiz-Ramirez et al in 2021, treatment of zebrafish with methanolic extract of Spondias purpurea seeds reduces blood glucose and cholesterol levels, and inhibits the formation of advanced glycation end products in eye samples to a percentage of The Relevance of Some Plant Extracts In Human Patients and Animal Models of Diabetes 98.5% for a dose of 90 mg/l, proving that its use can minimize diabetic complications [21].…”

Section: Animal Modelmentioning

confidence: 93%

The Relevance of Some Plant Extracts In Human Patients and Animal Models of Diabetes

BLAITI,

AMMARI,

CIOBICA

et al. 2023

AnnalsARSciBio

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Diabetes is a chronic disease characterized by hyperglycemia; medicinal plants have therapeutic uses in the management of diabetes. Various experiments have been conducted using animal models and clinical trials to explore the use of medicinal plants in the treatment of diabetes. The aim of this work is to present the relevance of some plant extracts in human patients and animal models of diabetes.

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Section: Animal Modelmentioning

confidence: 93%

The Relevance of Some Plant Extracts In Human Patients and Animal Models of Diabetes

BLAITI,

AMMARI,

CIOBICA

et al. 2023

AnnalsARSciBio

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“…Ethnobotanical, chemical, and pharmacological studies have been carried out worldwide to analyze their rich phytochemical compounds and their beneficial biological activities. 5 …”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic, Antihyperglycemic, and Toxic Effects of Physalis peruviana L. Aqueous and Methanolic Leaf Extracts in Wistar Rats

Kasali¹,

Kadima²,

Tusiimire³

et al. 2022

JEP

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Background Physalis peruviana L. (Solanaceae) is a plant widely used in traditional medicine systems to manage various diseases, including diabetes mellitus, which remains a global health problem in developing and developed countries. This study aimed to scientifically evaluate its antidiabetic bioactivity and short-term toxicity in rats. Methods We prepared various doses (100, 200, 400 mg/kg) of aqueous and methanolic leaf extracts for the antidiabetic study, and a dose of 2000 mg/Kg was prepared for the acute toxicity test. The first group that evaluated the hypoglycemic effect consisted of forty normoglycemic Wistar rats aged 7–8 months old with a weighted average of 265.8 ± 24.6 g. The second group consisted of intraperitoneal glucose-loaded male animals to evaluate the antihyperglycemic effect. The third group contained two groups of normoglycemic female rats (n = 3), aged 3 and 4 months old (weight average: 187.45 ± 14.82 g), treated for 14 days with aqueous and methanolic extracts (2 g/kg b.w) to assess mortality and toxic effects. Blood samples were taken at 30, 60, 90, and 120 min post-treatment in hypoglycemic and antihyperglycemic evaluations. Glibenclamide (5 mg/kg) was used as a reference drug. The control animals in each group did not receive the extracts. Results In hypoglycemic rats, 100 mg/kg of aqueous and methanolic extracts significantly lowered the fasting blood glucose level by 13.92% ( p < 0.0001) and 21.95% (p < 0.01), respectively, compared to the control group. In glucose tolerance test group, methanolic extracts significantly reduced hyperglycemia by 54.55% ( p < 0.0001), 46.50% ( p < 0.0001), 39.78% ( p < 0.0001) at 400, 200 and 100 mg/kg b.w, respectively, compared to control; aqueous extract 400 mg/kg reduced hyperglycemia by 39.44% ( p < 0.05). At the 2000 mg/kg dose, leaf aqueous and methanolic extracts did not show any signs of intoxication and mortality. Conclusion Crude aqueous and methanolic leaf extracts of P. peruviana ambrosioides appeared safe at 2000 mg/kg and have bioactivity in controlling the blood glucose levels, supporting their use in treating diabetes.

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Zebrafish: An Animal Model in Biomedical Research

Patel,

Srinivasan

2024

Animal Models in Research

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Evaluation of the Antidiabetic and Antihyperlipidemic Activity of Spondias purpurea Seeds in a Diabetic Zebrafish Model

Cited by 6 publications

References 67 publications

The Relevance of Some Plant Extracts In Human Patients and Animal Models of Diabetes

The Relevance of Some Plant Extracts In Human Patients and Animal Models of Diabetes

Hypoglycemic, Antihyperglycemic, and Toxic Effects of Physalis peruviana L. Aqueous and Methanolic Leaf Extracts in Wistar Rats

Zebrafish: An Animal Model in Biomedical Research

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