Evaluation of the antidiarrhoeal effects of Zizyphus spina-christi stem bark in rats

Adzu, Bulus; Amos, Samson; Amizan, M. B.; Gamaniel, K.

doi:10.1016/s0001-706x(03)00114-1

Cited by 96 publications

(80 citation statements)

References 18 publications

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“…The extract might have exerted its antidiarrheal activity via secretory mechanism as evident from reduction in total number of wet faeces. Furthermore, this antidiarrheal activity could have resulted from the inhibitory activity of aqueous leaf extract of C. sesamoides on prostanglandins synthesis, nitric oxide and platelet activating factors production, as inhibitors of prostaglandins and nitric oxide syntheses are known to delay diarrhea induced by castor oil (Capasso et al, 1994;Adzu et al, 2003;Tangpu and Yadav, 2004). Similar effects were reported in several studies by Qnais et al (2005), Akindele and Adeyemi (2006) and Appidi et al (2010) following the administration of aqueous leaf extracts of Juniperus phoenicia, Byrsocarpus coccineus and Hermania incana, respectively.…”

Section: Discussionsupporting

confidence: 67%

Antidiarrheal activity of aqueous leaf extract of Ceratotheca sesamoides in rats

Toyin

Khadijat

Salimon

et al. 2012

Bangladesh J Pharmacol

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The antidiarrheal effects of the aqueous leaf extract of C. sesamoides at 25, 50 and 100 mg/kg body weight was evaluated in female rats using gastrointestinal transit, diarrhea and enteropooling induced by castor oil models. The extract was positive for alkaloids, saponins, flavonoids and phenolics. The 25 mg/kg body weight of the extract significantly (p<0.05) prolonged the onset time of diarrhea, decreased the fecal parameters (number, water content, fresh weight, total number of wet feaces) with no episode in the animals treated with 50 and 100 mg/kg body weight. The activity of small intestine Na + -K + ATPase increased (p<0.05) while the nitric oxide, volume and mass of intestinal fluid as well as the distance travelled by the charcoal meal decreased. The patterns of changes were similar to the reference drugs. Overall, the antidiarrheal activity of the aqueous leaf extract of Ceratotheca sesamoides may be due to alkaloids, phenolics, flavonoids and saponins present in the extract. Article Info

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Section: Discussionsupporting

confidence: 67%

Antidiarrheal activity of aqueous leaf extract of Ceratotheca sesamoides in rats

Toyin

Khadijat

Salimon

et al. 2012

Bangladesh J Pharmacol

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“…The ZSC-3 fraction was more effective in controlling the blood glucose level than the other tested samples. This activity may be attributable to the presence of saponins glycosides [5]. Many studies have shown the blood glucose-lowering effect of plant extracts such as Boehmeria rugulosa [20], and have sought to evaluate the hypoglycemic effect in STZ-and alloxan-induced diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

“…A literature survey revealed that a number of terpenoids, flavonoids, isoquinoline alkaloids, cyclopeptide, and glycosidic terpenes are found in various quantities in almost all Ziziphus species. The leaves of the plants in that genus contain ceanothic and betulic acids, different saponins and flavonoids, triterpenoids [5]. Pharmacological screening studies of different crude extracts of Zizyphus spina Christi showed antidiarrheal [6], central depressant effect and antinociceptive effect.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, hypoglycemic and anti-diabetic activities of Ziziphus spina-christi (L) Willd (Rhamnacae) leaf extract

Al-Ghamdi¹,

Shahat²

2018

Trop. J. Pharm Res

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Purpose: To investigate the antioxidant, hypoglycemic and antidiabetic activities as well as the phenolic composition of Ziziphus spina-christi (ZSC) Methods: Eighty percent methanol extract (ZSC-1), as well as ethyl acetate (ZSC-2), n-butanol (ZSC-3) and aqueous (ZSC-4) fractions were administered orally to mice at doses of 250 and 500 mg/kg of body weight. The hypoglycemic and anti-diabetic activities of these fractions in the treated

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“…These results suggest that the methanol extract inhibits prostaglandins biosynthesis (Adzu et al, 2003).…”

Section: Discussionmentioning

confidence: 75%

Evaluation of the anti-diarrheal activity ofSalvia connivens

Gutiérrez

Mendoza

Peredo

et al. 2014

Pharmaceutical Biology

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Context: Diarrheal disease is a leading cause of mortality and morbidity and accounts for 5-8 million deaths worldwide each year. Salvia connivens Epling (Lamiaceae) is used to treat sore throat, fevers, diarrhea, malaria, and also is used as an antipyretic. Objective: The present study evaluates the efficacy of S. connivens in the treatment of diarrhea using animal models. Materials and methods: The anti-diarrheal effect of methanol extract of S. connivens was investigated on mice with castor oil, arachidonic acid (AA) or prostaglandin E 2 (PGE 2 )-induced diarrhea. On Wistar rats, the activity was evaluated on the intestinal transit and Castor oil-induced enteropooling. Results: The methanol extract at doses of 6.25, 12.5, 25, 50, 100, and 200 mg/kg on castor oil-induced diarrhea reduced the diarrhea by 32.3, 41.9, 67.7, 74.2, 83.3, and 100%, respectively. Additionally, this extract, at doses of 200 mg/kg, inhibited AA-induced diarrhea by 100%. The methanol extract produced no effect on PGE 2 -induced diarrhea at the same doses. In Wistar rats, at dose of 200 mg/kg, the methanol extract inhibited intestinal transit and decreased the volume of intestinal secretion induced by castor oil. Discussion: The methanol extract showed anti-diarrheal effect on the animal models used. Phytochemical screening revealed the presence of alkaloids, tannins, and saponins which may be responsible for this effect. The extract did not cause any mortality or any visible signs of toxicity or differences in food and water uptake were seen. Conclusions: These results justify the use of S. connivens as an anti-diarrheal agent.

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Evaluation of the antidiarrhoeal effects of Zizyphus spina-christi stem bark in rats

Cited by 96 publications

References 18 publications

Antidiarrheal activity of aqueous leaf extract of Ceratotheca sesamoides in rats

Antidiarrheal activity of aqueous leaf extract of Ceratotheca sesamoides in rats

Antioxidant, hypoglycemic and anti-diabetic activities of Ziziphus spina-christi (L) Willd (Rhamnacae) leaf extract

Evaluation of the anti-diarrheal activity ofSalvia connivens

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