Evaluation of the antimicrobial activity of Cinnamomum zeylanicum essential oil and trans-Cinnamaldehyde against resistant Mycobacterium tuberculosis

Mota, Aquiles Paulino Peres; Campelo, Thales Alves; Frota, Cristiane Cunha

doi:10.14393/bj-v35n1a2019-41710

Cited by 8 publications

(4 citation statements)

References 33 publications

(39 reference statements)

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“…Hence, it is favorable to have extracts with high concentrations of Cinnamic acid for better diabetic control. Cinnamaldehyde is identified as the major compound present in Cinnamon extracted using hydro distillation in several studies (Kaskoos, 2019;Mota, Campelo & Frota, 2019). The α-amylase inhibition evaluated using a combination of (E)-Cinnamaldehyde and (E)-Cinnamyl acetate has shown better potency than Cinnamaldehyde alone (Sihoglu Tepe & Ozaslan, 2020).…”

Section: /18mentioning

confidence: 99%

In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts

Wariyapperuma

Kannangara

Wijayasinghe

et al. 2020

PeerJ

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Background Diabetes mellitus type 2 (DMT2) is a leading metabolic disorder in the world. Anti-diabetic actions of phytochemicals from various medicinal herbs have been explored as an alternative therapy in the management of DMT2 due to adverse effects of synthetic drugs used in allopathic medicine. α-amylase and α-glucosidase inhibitory potential and phytochemical profiling were investigated in aqueous extracts of two new Cinnamomum zeylanicum accessions, namely C. zeylanicum Sri Wijaya (SW), C. zeylanicum Sri Gemunu (SG) and commercially available C. zeylanicum (CC). Methods Microwave Digestion (MD), Pressurized Water Extraction (PWE), Steam Distillation (SD), Solvent Extraction (SE), Decoction Water Extraction (DWE) and Infusion Water Extraction (IWE) methods were used to prepare Cinnamon quill extracts. Total phenolic content (TPC, Folin-Ciocalteu method) and Proanthocyanidin content (PC, vanillin assay), α-amylase and α-glucosidase inhibition of Cinnamon extracts were determined spectrophotometrically. The α-amylase and α-glucosidase inhibition were reported in terms of IC50 value. The phytochemical profiling was accomplished by GC-MS technique. Results and Discussion Lowest IC50 values were observed in PWE and DWE of SW. The highest PC and TPC were also observed in PWE and DWE of SW. Pressured water and decoctions are promising methods for the extraction of antidiabetic constituents from cinnamon. Benzoic acid, cinnamyl alcohol, benzyl alcohol, and 4-Allyl-2,6-dimethoxyphenol were identified as major compounds in SW extracts. These compounds are believed to be responsible for strong enzyme inhibitory activity of the extracts. Conclusions This is the first study to explore the use of pressured and decoctions water to extract anti-diabetic phytochemicals from cinnamon. The extensive metabolite profiling of novel SW and SG extracts and comparison of that with commercially available CC are reported for the first time in this study. The C. zeylanicum, SW accession holds some promise in the management of diabetes.

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Section: /18mentioning

confidence: 99%

In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts

Wariyapperuma

Kannangara

Wijayasinghe

et al. 2020

PeerJ

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“…2015; Mota et al . 2019). Even there are reports suggested that trans‐cinnamide at its sub‐MIC (1 µg ml −1 ) has a synergistic effect with first‐line TB antibiotics, mainly isoniazid, and RIF by inhibiting the synthesis of mycolic acid and proteins (Rastogi et al .…”

Section: Ethnomedicinal Plants Of India and Their Key Bioactive Molecules On Tb Managementmentioning

confidence: 99%

Potent anti‐mycobacterial and immunomodulatory activity of some bioactive molecules of Indian ethnomedicinal plants that have the potential to enter in TB management

et al. 2021

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Tuberculosis (TB), is one of the deadliest infectious-diseases of human-civilization. Approximately one-third of global-population is latently-infected with the TB-pathogen Mycobacterium tuberculosis (M.tb). The discovery of anti-TB antibiotics leads to decline in death-rate of TB. However, the evolution of antibiotic-resistant, M.tb-strain, and the resurgence of different immune compromised diseases re-escalated the death-rate of TB. WHO has already cautioned about the chances of pandemic-situation in TB endemic countries unless the discovery of new antitubercular drugs, i.e., the need of the hour. Analysing the pathogenesis of TB it was found that M.tb evades the host by altering the balance of immune-response and affects either by killing the cells or by creating inflammation. In the preantibiotic era, traditional medicines were only therapeutic measures for different infectious-diseases including tuberculosis. The ancient-literatures of India or ample Indian traditional knowledge and ethnomedicinal-practices are evidence for the treatment of TB using different indigenous plants. However, in the light of modern scientific approach, anti-TB effects of those plants and their bioactive-molecules were not established thoroughly. In this review, focus has been given on five bioactive-molecules of different traditionally used Indian ethnomedicinal plants for treatment of TB or TB-like symptom. These compounds are also validated with proper identification and their mode of action with modern scientific approaches. The effectiveness of these molecules for sensitive or drug-resistant TB-pathogen in clinical or preclinical studies were also evaluated. Thus, our specific aim is to highlight such scientifically validated bioactive compounds having anti-mycobacterial and immuno-modulatory activity for future use as medicine or adjunct-therapeutic molecule for TB management.

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“…The chemical composition in the aqueous extracts in our study, slightly deviated from Hafizur et al, (2015) Manuscript to be reviewed acid for better diabetic control. Cinnamaldehyde is identified as the major compound present in Cinnamon extracted using hydro distillation in several studies (Paranagama et al, 2001;Kaskoos, 2019;Mota, Campelo & Frota, 2019). The α-amylase inhibition evaluated using a combination of (E)-Cinnamaldehyde and (E)-Cinnamyl acetate has shown better potency than Cinnamaldehyde alone (Sihoglu Tepe & Ozaslan, 2020).…”

Section: Gc-ms Technique Is a Powerful And Suitable Tool For The Detementioning

confidence: 99%

Peer Review #1 of "In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts (v0.1)"

Nasri¹

2020

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Background: Diabetes mellitus type 2 (DMT2) is a common metabolic disorder in the world. Antidiabetic actions of phytochemicals from various medicinal herbs are considered as an alternative to the drugs used in the management of DMT2 in allopathic medicine due to adverse effects of synthetic drugs. α-amylase and α-glucosidase inhibitory potential and phytochemical profiling were investigated in aqueous extracts of two new Cinnamomum zeylanicum accessions, namely C. zeylanicum Sri Wijaya (SW), C. zeylanicum Sri Gemunu (SG) and commercially available C. zeylanicum (CC). Methods: Microwave Digestion (MD), Pressurized Water Extraction (PWE), Steam Distillation (SD), Solvent Extraction (SE), Decoction Water Extraction (DWE) and Infusion Water Extraction (IWE) methods were used to prepare Cinnamon quill extracts. Total phenolic content (TPC, Folin-Ciocalteu method) and Proanthocyanidin content (PC, vanillin assay), α-amylase and α-glucosidase inhibition of Cinnamon extracts were determined spectrophotometrically. The α-amylase and α-glucosidase inhibition were reported in terms of IC 50 value. The phytochemical profiling was accomplished by GC-MS technique. Results and discussion: Lowest IC 50 values were observed in PWE and DWE of SW. Highest PC and TPC was also observed in PWE and DWE of SW. Pressured water and decoctions are promising methods for the extraction of antidiabetic constituents from Cinnamon. Benzoic acid, Cinnamyl alcohol, Benzyl alcohol, and 4-Allyl-2,6-dimethoxyphenol were identified as major compounds in SW extracts. These compounds are believed to be responsible for strong enzyme inhibitory activity of the extracts. Conclusions: This is the first study to explore the use of pressured and decoctions water to extract antidiabetic phytochemicals from Cinnamon. The extensive metabolite profiling of novel SW and SG extracts and comparison of that with commercially available CC are reported for the first time in this study. The C. zeylanicum, SW accession holds some promise in the management of diabetes.

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Evaluation of the antimicrobial activity of Cinnamomum zeylanicum essential oil and trans-Cinnamaldehyde against resistant Mycobacterium tuberculosis

Cited by 8 publications

References 33 publications

In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts

In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts

Potent anti‐mycobacterial and immunomodulatory activity of some bioactive molecules of Indian ethnomedicinal plants that have the potential to enter in TB management

Peer Review #1 of "In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts (v0.1)"

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