Evaluation of the Antimicrobial Effect of &amp;lt;i&amp;gt;Nepeta cataria&amp;lt;/i&amp;gt; and &amp;lt;i&amp;gt;Basella alba&amp;lt;/i&amp;gt; against Clinically Resistant &amp;lt;i&amp;gt;Acinetobacter baumannii&amp;lt;/i&amp;gt; in Nairobi, Kenya

Morombaye, Salome Marlene; Kangogo, Mourine; Revathi, Gunturu; Nyerere, Andrew; Ochora, J

doi:10.4236/aim.2018.810052

Cited by 2 publications

(1 citation statement)

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“…subtilis and its oil as a topical treatment of respiratory tract infections (Suschke et al, 2007;Bandh and Kamili, 2011) using combined extractions of all solvents in DMSO, N. cataria plant extract at the dose level of 12.5 µl/ml showed maximum inhibition of all the bacterial strains, followed by 6.25 µl/ml. The antibacterial screening of the N. cataria from other studies also exhibited sufficient evidence of antibacterial activity against S. aureus, K. pneumoniae, and S. typhi (Morombaye et al, 2018). GC/MS analysis of methanol and ethanol revealed the presence of betulin extracts, which is a promising antitumorigenic candidate and escalates the importance of N. cataria in cancer treatment (Liu et al, 2009).…”

Section: Discussionmentioning

confidence: 93%

Phytochemical profiling of antimicrobial and potential antioxidant plant: Nepeta cataria

Nadeem

Shahzad²,

Ahmed³

et al. 2022

Front. Plant Sci.

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Traditional and phytochemical studies have confirmed the richness and diversity of medicinal plants such as Nepeta cataria (N. cataria), but more studies are needed to complete its metabolite profiling. The objective of this research was to enhance the metabolomic picture and bioactivity of N. cataria for better evaluation. Phytochemical analysis was performed by bio-guided protocols and gas chromatography-mass spectrometry (GC/MS). For this, solvents such as methanol, ethanol, water, acetone, and hexane were used to extract a wide number of chemicals. Antibacterial analysis was performed using the 96-well plate test, Kirby Bauer's disk diffusion method, and the resazurin microdilution test. Antioxidant activity was determined by the DPPH assay and radical scavenging capacity was evaluated by the oxygen radical absorbance capacity (ORAC) assay. GC/MS analysis revealed a total of 247 identified and 127 novel metabolites from all extracts of N. cataria. Water and acetone extracts had the highest identified metabolites (n = 79), whereas methanol extract was the highest in unidentified metabolites (n = 48). The most abundant phytochemicals in methanol extract were 1-isopropylcyclohex-1-ene (concentration = 27.376) and bicyclo [2.2.1] heptan-2-one (concentration = 20.437), whereas in ethanol extract, it was 9,12,15-octadecatrienoic acid (concentration = 27.308) and 1-isopropylcyclohex-1-ene (concentration = 25.854). An abundance of 2 methyl indoles, conhydrin, and coumarin was found in water extracts; a good concentration of eucalyptol was found in acetone extract; and 7,9-di-tert-butyl-1-oxaspiro is the most abundant phytochemicals in hexane extracts. The highest concentration of flavonoids and phenols were identified in hexane and methanol extracts, respectively. The highest antioxidant potential (DPPH assay) was observed in acetone extract. The ethanolic extract exhibited a two-fold higher ORAC than the methanol extract. This examination demonstrated the inhibitory effect against a set of microbes and the presence of polar and non-polar constituents of N. cataria. The results of this study provide a safe resource for the development of food, agriculture, pharmaceutical, and other industrial products upon further research validation.

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Section: Discussionmentioning

confidence: 93%

Phytochemical profiling of antimicrobial and potential antioxidant plant: Nepeta cataria

Nadeem

Shahzad²,

Ahmed³

et al. 2022

Front. Plant Sci.

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A Systematic Review Study on the Effectiveness of Medicinal Plants Against Acinetobacter baumannii

Shakib

Manouchehri

Marzban

et al. 2023

CCB

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Introduction: Acinetobacter baumannii is an opportunistic bacterium capable of causing nosocomial infections resistant to a wide range of antibiotics. Herbal medicines could become the source of novel therapies for antibiotic-resistant bacteria. This review paper aimed to survey the effectiveness of medicinal plants in treating infections caused by A. baumannii. Methods: The relevant data was obtained by systematically searching PubMed, ISI Web of Science, Scopus, Science Direct, and Google Scholar databases with the specific keywords of medicinal plants (including extracts and essential oils) and bacterial infections (including A. baumannii). Results: The present review identified 23 studies published between 2009 and 2021 that discussed the effectiveness of medicinal plants in inhibiting the growth of A. baumannii. In these studies, 28 medicinal plants were found effective against infection caused by A. baumannii in vivo. Conclusion: The results of this review indicated that to develop a therapeutic strategy for treating bacterial infections, especially A. baumannii, based on medicinal plants, extensive studies were required to determine their cytotoxicity and therapeutic dosage before they could be used as an alternative to antibiotics.

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Evaluation of the Antimicrobial Effect of <i>Nepeta cataria</i> and <i>Basella alba</i> against Clinically Resistant <i>Acinetobacter baumannii</i> in Nairobi, Kenya

Cited by 2 publications

References 24 publications

Phytochemical profiling of antimicrobial and potential antioxidant plant: Nepeta cataria

Phytochemical profiling of antimicrobial and potential antioxidant plant: Nepeta cataria

A Systematic Review Study on the Effectiveness of Medicinal Plants Against Acinetobacter baumannii

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