Evaluation of the antioxidant and cytotoxic activity of arzanol, a prenylated α-pyrone–phloroglucinol etherodimer from Helichrysum italicum subsp.microphyllum

Rosa, Antonella; Deiana, Monica; Atzeri, Angela; Corona, Giulia; Incani, Alessandra; Melis, Maria Paola; Appendino, Giovanni; Dessì, Ma

doi:10.1016/j.cbi.2006.11.006

Cited by 82 publications

(74 citation statements)

References 26 publications

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“…1; 5), the MTT assay and the measurement of lactate dehydrogenase release were performed in Vero cells cultures and the results showed that arzanol did not exhibit toxicity at any of the tested concentrations (0.5-40 PM) (Rosa et al, 2007).…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…(Sala et al, 2003b) 4-hydroxy-3-(2-hydroxy-3-isopentenyl)acetophenone 44 111 (Sala et al, 2003b) Gnaphaliin 94 - (Sala et al, 2003a) Pinocembrin 96 - (Sala et al, 2003a) Both the whole acetone extract and arzanol ( Fig. 1; 5 (Appendino et al, 2007) as well as the biosynthesis of PGE 2 in whole blood (Bauer et al, 2011).…”

Section: Plant Extracts and Chemical Compositionmentioning

confidence: 99%

“…However, his findings were published in journals of very little importance and were largely ignored after his death (Appendino et al, 2007;Bauer et al, 2011;Campanini, 2004). Consequently, the search of the keywords "Helichrysum italicum" or "H. italicum" in a scientific database such as PubMed reveals that the majority of research work related to this plant has been published after the 90s and up to now.…”

Section: Introductionmentioning

confidence: 99%

“…), also known as "perpétuas-das-areias", "perpétuas-de-Itália", "immortelle" or "everlasting" (Ivanovic et al, 2011), is an aromatic shrub 30-70 cm high . It exhibits a strong and persistent smell similar to curry (Appendino et al, 2007), has yellow flowers and blossoms between May and June (Bianchini et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

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Helichrysum italicum: From traditional use to scientific data

Viegas¹,

Palmeira‐de‐Oliveira²,

Salgueiro³

et al. 2014

Journal of Ethnopharmacology

139

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Ethnopharmacological relevanceHelichrysum italicum (Roth) G. Don fil. (family Asteraceae) has been used for its medicinal properties for a long time and, even nowadays, continues to play an important role in the traditional medicine of Mediterranean countries. Based on this traditional knowledge, its different pharmacological activities have been the focus of active research. Aim of the reviewTo provide an overview of the current state of knowledge of the pharmacological activities of H. italicum, as well as its traditional uses, toxicity, drug interactions and safety. Materials and methodsThe selection of relevant data was made through a search using the keywords "Helichrysum italicum" and "H. italicum" in "Directory of Open Access Journals", "Google Scholar", "ISI Web of Knowledge", "PubMed", "ScienceDirect" and "Wiley Online Library". Information obtained in local and foreign books and other sources was also included. ResultsThere are reports on the traditional use of H. italicum in European countries, particularly Italy, Spain, Portugal and Bosnia and Herzegovina. In these countries, its flowers and leaves are the most used parts in the treatment of health disorders such as allergies, colds, cough, skin, liver and gallbladder disorders, inflammation, infections and sleeplessness. In order to validate some of the traditional uses of H. italicum italicum in vivo activity, the highlight goes to the anti-erythematous and photoprotective activities of its flavonoids, demonstrated both in animals and humans, and to the anti-inflammatory properties exhibited by its flavonoids, acetophenones and phloroglucinols, as seen in animal models. Concerning its safety and adverse effects, while H. italicum does not display significant levels of cytotoxicity or genotoxicity, it should be noticed that one of its flavonoids inhibited some CYP isoforms and a case has been reported of an allergic reaction to its extracts. Aim of the reviewTo provide an overview of the current state of knowledge of the pharmacological activities of H. italicum, as well as its traditional uses, toxicity, drug interactions and safety. Materials and methodsThe selection of relevant data was made through a search using the keywords "Helichrysum italicum" and "H. italicum" in "Directory of Open Access Journals", "Google Scholar", "ISI Web of Knowledge", "PubMed", "ScienceDirect" and "Wiley Online Library". Information obtained in local and foreign books and other sources was also included. ResultsThere are reports on the traditional use of H. italicum in European countries, particularly Italy, Spain, Portugal and Bosnia and Herzegovina. In these countries, its flowers and leaves are the most used parts in the treatment of health disorders such as allergies, colds, cough, skin, liver and gallbladder disorders, italicum in vivo activity, the highlight goes to the anti-erythematous and photoprotective activities of its flavonoids, demonstrated both in animals and humans, and to the anti-inflammatory properties exhibited by its flavonoids, acet...

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Section: In Vivo Studiesmentioning

confidence: 99%

Section: Plant Extracts and Chemical Compositionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Helichrysum italicum: From traditional use to scientific data

Viegas¹,

Palmeira‐de‐Oliveira²,

Salgueiro³

et al. 2014

Journal of Ethnopharmacology

139

View full text Add to dashboard Cite

show abstract

“…However, there are few reports in literature about the genotoxic, cytotoxic and mutagenic effects of Helichrysum species. Reid et al (2006) Idaomar et al 2002;Nostro et al 2003;Rosa et al 2007). Elgorashi and van Staden (2007) reported mutagenic effects of methanol extracts of H. simillimum.…”

mentioning

confidence: 99%

Cytogenetic effects of nine Helichrysum taxa in human lymphocytes culture

et al. 2009

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Helichrysum Mill. (Asteraceae) species have been used in folk medicine for thousands of years in the world. The in vitro cytogenetic effects in human lymphocytes of nine Helichrysum taxa used in Turkey folk medicine were investigated. Blood samples were obtained from healthy donors, nonsmoking volunteers, which were incubated and exposed to increasing concentrations of methanol extracts of Helichrysum taxa (0.01, 0.05, 0

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Biological Phlorotannins of Eisenia bicyclis

Lee

Kim²

2015

Marine Algae Extracts

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Evaluation of the antioxidant and cytotoxic activity of arzanol, a prenylated α-pyrone–phloroglucinol etherodimer from Helichrysum italicum subsp.microphyllum

Cited by 82 publications

References 26 publications

Helichrysum italicum: From traditional use to scientific data

Helichrysum italicum: From traditional use to scientific data

Cytogenetic effects of nine Helichrysum taxa in human lymphocytes culture

Biological Phlorotannins of Eisenia bicyclis

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