Evaluation of the Antioxidant Capacity and Preventive Effects of a Topical Emulsion and Its Vehicle Control on the Skin Response to UV Exposure

Zhai, Hongbo; Behnam, Shahdad E; Villarama, Clarissa D.; Arens-Corell, M.; Choi, Myeong Jun; Maibach, Howard I.

doi:10.1159/000088014

Cited by 33 publications

(21 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Supplying topical exogenous antioxidants to the skin can prevent or minimize UVB-induced damage [18] . Despite various reports linking many of the beneficial properties of selenium to its use, no comprehensive study has been conducted to investigate the skin absorptive ability of related compounds.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

In vitro and in vivo percutaneous absorption of seleno-L-methionine, an antioxidant agent, and other selenium species

Lin

Fang²,

Al‐Suwayeh

et al. 2011

Acta Pharmacol Sin

View full text Add to dashboard Cite

Aim: To investigate the in vitro and in vivo percutaneous absorption of seleno-L-methionine (Se-L-M), an ultraviolet (UV)-protecting agent, from aqueous solutions. Methods: Aqueous solutions of Se-L-M were prepared in pH 4, 8, and 10.8 buffers. The pH 8 buffer contained 30% glycerol, propylene glycol (PG) and polyethylene glycol (PEG) 400. The in vitro skin permeation of Se-L-M via porcine skin and nude mouse skin was measured and compared using Franz diffusion cells. The in vivo skin tolerance study was performed, which examined transepidermal water loss (TEWL), skin pH and erythema. Results: In the excised porcine skin, the flux was 0.1, 11.4 and 8.2 μg· cm -2 ·h -1 for the pH 4, 8, and 10.8 buffers, respectively. A linear correlation between the flux and skin deposition was determined. According to permeation across skin with different treatments (stripping, delipidation, and ethanol treatments), it was determined that the intracellular route comprised the predominant pathway for Se-L-M permeation from pH 8 buffer. Aqueous solutions of seleno-DL-methionine (Se-DL-M), selenium sulfide and selenium-containing quantum dot nanoparticles were also used as donor systems. The DL form showed a lower flux (7.0 vs 11.4 μg· cm -2 ·h -1 ) and skin uptake (23.4 vs 47.3 μg/g) as compared to the L form, indicating stereoselective permeation of this compound. There was no or only negligible permeation of selenium sulfide and quantum dots into and across the skin. With in vivo topical application for 4 and 8 h, the skin deposition of Se-L-M was about 7 μg/g, and values were comparable to each other. The topical application of Se-L-M for up to 5 d did not caused apparent skin irritation. However, slight inflammation of the dermis was noted according to the histopathological examination. Conclusion: Se-L-M was readily absorbed by the skin in both the in vitro and in vivo experiments. The established profiles of Se-L-M skin absorption will be helpful in developing topical products of this compound.Keywords: seleno-L-methionine; selenium; percutaneous absorption; topical delivery; skin [5] . In humans, a low selenium status is associated with up to a 4-fold increased risk of developing skin cancer [6] . Topical selenium compounds also increase the minimum dose of UV radiation required to cause skin reddening and protect against skin damage caused by UVB [7,8] . Seleno-L-methionine (Se-L-M), the major component of dietary selenium, represents an organic form of selenium which may provide enhanced protection of the skin [9] . Se-L-M also decreases the oxidative stress of neurodegenerative diseases, rheumatoid arthritis, and HIV/AIDS [10,11] . Most ingested selenium, whether in organic or inorganic form, is converted by liver metabolism [3] . In addition, selenium toxicity can produce gastrointestinal problems [12] . Delivery of pharmacologically active compounds via the skin is an attractive alternative to oral dosing for numerous reasons including stable plasma concentrations, bypass of firstpass effects, and reduction of some si...

show abstract

Section: Discussionmentioning

confidence: 99%

“…It was shown that the complete removal of lipids from the SC led to a 100-fold increase in water permeability [50] . Healthy skin has a slightly acidic pH, and the acidity of the skin maintains antimicrobial activity [18] . Disturbing this naturally acidic mantle may cause skin diseases.…”

Section: Discussionmentioning

confidence: 99%

In vitro and in vivo percutaneous absorption of seleno-L-methionine, an antioxidant agent, and other selenium species

Lin

Fang²,

Al‐Suwayeh

et al. 2011

Acta Pharmacol Sin

View full text Add to dashboard Cite

show abstract

“…Vitamin C kadar güçlü bir antioksidan değildir. Foto hasara karşı ve cildin neminin düzenlenmesi için kullanılmaktadır 42 . Nikotinamid (B3) ile yapılan bir çalışmada transepidermal su kaybının azaldığı ve bu nedenle kronolojik yaşlanmaya karşı kullanılabileceği belirtilmiştir 43 .…”

Section: Kollajen Ve Elastin Ile Bu Yapıları Destekleyen Bileşenlerunclassified

Anti-Aging Cosmetics Approaches and Components in Products

Yapar¹,

Tanrıverdi²

2016

BSBD

View full text Add to dashboard Cite

Cilt yaşlanması; iç veya dış faktörlerin veya bunların birlikteliğinin neden olduğu karmaşık biyolojik bir süreçtir. Gelişen üretim teknolojileri, farmasötik taşıyıcı sistemlerin kozmetik formüllerinde kullanılması ve yenilikçi bileşenlere dayalı yeni nesil kozmetik ürünler, temel kozmetik bakımdan ileri alternatifler sunmaktadır. İleri teknoloji kullanılarak üretilen kozmetik aktif bileşenleri, doğal kaynaklı hammaddelerin kozmetik bileşenleri olarak kullanımının artması ve farmasötik taşıyıcı sistemlerin kozmetik formüllerinde kullanılması ile geliştirilen kozmetik ürünler toplumların artan kozmetik beklentilerini karşılamayı hedeflemektedir. Bu derlemede, günümüzde bireylerin dış ve iç faktörler ile artan cilt yaşlanmasının, kozmetik ürün odaklı çözümleri özellikle bileşenler açısından irdelenmiş, yaşlanma karşıtı farklı yaklaşımlar özetlenmiş ve kullanılan taşıyıcı sistemler belirtilmiştir.

show abstract

“…All the 4 vitamins may have an antioxidant effect on the stratum corneum [12,[16][17][18][19][20][21][22]. Furthermore, both vitamin A in the precursor form of retinol and in the activated form of retinoic acid and vitamins C and B3 can promote the neosynthesis of collagen in the dermis [16,19,[22][23][24][25][26][27].…”

Section: Open Accessmentioning

confidence: 99%

Tolerability and hydrating effects of an anti-aging gynaecological collagen cream in women in menopause

Stefano¹,

Radicioni²,

Vele³

et al. 2014

OJOG

View full text Add to dashboard Cite

Background and Aims: A gynaecological cream containing collagen, phytocollagen, hyaluronate and vitamins was investigated in women in menopause. Methods: The cream was daily applied to the vaginal mucosa and the perineal skin as well as to the abdominal skin (healthy skin used as control) for 1 week and then on alternate days for other 2 weeks. Skin hydration and viscoelasticity were measured at baseline and after 8 and 21 days by Corneometer ® CM 825 and Cutometer ® MPA 850, respectively. The product use comfort and the moisturising of the vaginal mucosa were evaluated by the volunteers through a questionnaire and a visual analogue scale, respectively. Results: The local tolerability was excellent for nearly all of the volunteers (90% -95%) and according both to dermatologist's and gynaecologist's evaluation. Related adverse reactions had a frequency of 15% (10% vulvovaginal burning sensation and 5% vulvovaginal discomfort). The topical hydration increased both in the perineal and the abdominal skin. Hydration increase vs. baseline was more marked on day 8 than on day 21 and was significant in the abdominal skin (p-value < 0.0001). The vaginal moisturising improved significantly (p-value < 0.0001) both on day 8 and 21 vs. baseline. Small changes in the viscoelasticity parameters were observed in both the perineal and the abdominal skin. Few significant improvements were R1 and R8 decreases in the perineum and R0 increase in the abdomen. Conclusions: The tested cream represents a safe product with proven moisturising effect towards the vaginal mucosa when daily applied by menopausal women.

show abstract

Evaluation of the Antioxidant Capacity and Preventive Effects of a Topical Emulsion and Its Vehicle Control on the Skin Response to UV Exposure

Cited by 33 publications

References 57 publications

In vitro and in vivo percutaneous absorption of seleno-L-methionine, an antioxidant agent, and other selenium species

In vitro and in vivo percutaneous absorption of seleno-L-methionine, an antioxidant agent, and other selenium species

Anti-Aging Cosmetics Approaches and Components in Products

Tolerability and hydrating effects of an anti-aging gynaecological collagen cream in women in menopause

Contact Info

Product

Resources

About