Evaluation of the antipsychotic effect of bi-acetylated l-stepholidine (l-SPD-A), a novel dopamine and serotonin receptor dual ligand

Guo, Yang; Hai, Zhang; Chen, Xuetao; Cai, Wenxian; Cheng, Jianjun; Yang, Yushe; Jin, Guo-Zhang; Zhen, Xuechu

doi:10.1016/j.schres.2009.08.002

Cited by 28 publications

(13 citation statements)

References 45 publications

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“…Asenapine has been shown to increase mPFC and hippocampal dopamine release (Huang et al 2008;Franberg et al 2009). I-SPD-A, another putative antipsychotic with D1 agonist/5-HT1A partial agonist/D2 antagonist efficacy, also rescued a PCPinduced deficit with a 24-h delay (Guo et al 2009). So too did aripiprazole, acting via a D1/5-HT1A-dependent mechanism (Nagai et al 2009).…”

Section: Phencyclidine (Pcp)mentioning

confidence: 94%

Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models

2011

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Section: Phencyclidine (Pcp)mentioning

confidence: 94%

Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models

2011

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“…The hyperlocomotory effect of PCP administration was confirmed by measuring the number of infrared beam breaks performed by each rat using a Double IR Actimeter Harvard system (such as described in Ref. 17; Harvard Apparatus, Kent, UK). Two PCP models were investigated (below).…”

Section: Methodsmentioning

confidence: 99%

Identification of Targeted Analyte Clusters for Studies of Schizophrenia

Cheng

Guest

et al. 2010

Molecular & Cellular Proteomics

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The search for biomarkers to diagnose psychiatric disorders such as schizophrenia has been underway for decades. Many molecular profiling studies in this field have focused on identifying individual marker signals that show significant differences in expression between patients and the normal population. However, signals for multiple analyte combinations that exhibit patterned behaviors have been less exploited. Here, we present a novel approach for identifying biomarkers of schizophrenia using expression of serum analytes from first onset, drug-naïve patients and normal controls. The strength of patterned signals was amplified by analyzing data in reproducing kernel spaces. This resulted in the identification of small sets of analytes referred to as targeted clusters that have discriminative power specifically for schizophrenia in both human and rat models. These clusters were associated with specific molecular signaling pathways and less strongly related to other neuropsychiatric disorders such as major depressive disorder and bipolar disorder. These results shed new light concerning how complex neuropsychiatric diseases behave at the pathway level and demonstrate the power of this approach in identification of disease-specific biomarkers and potential novel therapeutic strategies. Molecular & Cellular Proteomics 9: 510 -522, 2010.

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“…Compelling research studies have shown that many types of effective components from natural products were effective agents against central nervous system diseases. For example, huperzine A and l-stepholidine (l-SPD), which have been proven to be efficient at reversing cognitive deficits, appear to be good candidates for the treatment of Alzheimer's disease and schizophrenia, respectively [19,20] . Recent research suggests that timosaponin, which is derived from Rhizoma Anemarrhenae, has unique sedative action on mice with neural dysfunction caused by stress.…”

Section: Introductionmentioning

confidence: 99%

Timosaponin derivative YY-23 acts as a non-competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice

Zhang

Guo

et al. 2015

Acta Pharmacol Sin

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Aim: N-methyl-D-aspartic acid (NMDA) receptor modulators have shown promising results as potential antidepressant agents, whereas timosaponins extracted from the Chinese herb Rhizoma Anemarrhenae exhibit antidepressant activities. In the present study we examined whether YY-23, a modified metabolite of timosaponin B-III, could affect NMDA receptors in rat hippocampal neurons in vitro, and evaluated its antidepressant-like effects in stressed mice. Methods: NMDA-induced currents were recorded in acutely dissociated rat hippocampal CA1 neurons using a whole-cell recording technique. C57BL/6 mice were exposed to a 6-week chronic mild stress (CMS) or a 10-d chronic social defeat stress (CSDS). The stressed mice were treated with YY-23 (20 mg·kg -1 ·d -1 ) or a positive-control drug, fluoxetine (10 mg·kg -1 ·d -1 ) for 3 weeks. Behavioral assessments were carried out every week. Results: In acutely dissociated rat hippocampal CA1 neurons, YY-23 selectively and reversibly inhibited NMDA-induced currents with an EC 50 value of 2.8 μmol/L. This inhibition of NMDA-induced currents by YY-23 was non-competitive, and had no features of voltagedependency or use-dependency. Treatment of the stressed mice with YY-23 not only reversed CMS-induced deficiency of sucrose preference and immobility time, and CSDS-induced reduction of social interaction, but also had faster onset as compared to fluoxetine. Conclusion: YY-23 is a novel non-competitive antagonist of NMDA receptors with promising rapid antidepressant-like effects in mouse models of CMS and CSDS depression.

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Evaluation of the antipsychotic effect of bi-acetylated l-stepholidine (l-SPD-A), a novel dopamine and serotonin receptor dual ligand

Cited by 28 publications

References 45 publications

Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models

Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models

Identification of Targeted Analyte Clusters for Studies of Schizophrenia

Timosaponin derivative YY-23 acts as a non-competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice

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