Evaluation of the association between GHR exon 3 polymorphism and polycystic ovary syndrome among Han Chinese women

Shen, Yun; Wang, Laicheng; Zhao, Yong; You, Li; Geng, Ling; Gu, Harvest F.; Chen, Zi‐Jiang

doi:10.1016/j.ghir.2011.07.002

Cited by 7 publications

(7 citation statements)

References 19 publications

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“…On the other hand, comparing with healthy controls in same ethnic groups, especially Korea and China, the d3/d3 genotype was present lower (3.2% to 7.2% of cases) than that of other ethnic groups spoken above. In distribution of genotype with d3 allele (d3/d3+d3/fl), patients with acromegaly from Italy, France, Mexico were higher as 45.7% to 54% than the present study (13.3%) and the study with healthy controls in Korea (27.4%) and China (25.4%) [ 7 14 16 17 18 19 ]. While this may suggest the existence of ethnic differences in the frequency of d3-GHR genotypes, some limitations to the present study must be considered.…”

Section: Discussioncontrasting

confidence: 74%

Association between the Growth Hormone Receptor Exon 3 Polymorphism and Metabolic Factors in Korean Patients with Acromegaly

et al. 2015

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BackgroundThis study investigated the association between the frequency of growth hormone receptor (GHR) exon 3 polymorphism (exon 3 deletion; d3-GHR) and metabolic factors in patients with acromegaly in Korea.MethodsDNA was extracted from the peripheral blood of 30 unrelated patients with acromegaly. GHR genotypes were evaluated by polymerase chain reaction and correlated with demographic data and laboratory parameters.ResultsNo patient had the d3/d3 genotype, while four (13.3%) had the d3/fl genotype, and 26 (86.7%) had the fl/fl genotype. Body mass index (BMI) in patients with the d3/fl genotype was significantly higher than in those with the fl/fl genotype (P=0.001). Age, gender, blood pressure, insulin-like growth factor-1, growth hormone, fasting plasma glucose, triglycerides, high density lipoprotein cholesterol, and low density lipoprotein cholesterol levels showed no significant differences between the two genotypes.ConclusionThe d3-GHR polymorphism may be associated with high BMI but not with other demographic characteristics or laboratory parameters.

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Section: Discussioncontrasting

confidence: 74%

Association between the Growth Hormone Receptor Exon 3 Polymorphism and Metabolic Factors in Korean Patients with Acromegaly

et al. 2015

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“…Those of Asian ancestry including Indian, Chinese, Japanese and Korean were more likely to carry the fl/fl GHR genotype as previously reported (76% on average) [9, 29–32]. However, the GHR exon 3 deletion allele has only been shown to affect height, weight and metabolic parameters in Chinese participants [31, 32].…”

Section: Discussionsupporting

confidence: 50%

A descriptive study on selected growth parameters and growth hormone receptor gene in healthy young adults from the American Midwest

Hartin

Hossain

Manzardo

et al. 2018

Growth Hormone & IGF Research

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“…The receptor Scarb1 was differentially expressed in DDT lineage granulosa and has been associated with POI [51]. The growth factor IGF1 and the receptors Pdgfra and Ghr were also differentially expressed in the DDT lineage and have been implicated in PCOS [52–54]. Therefore, differentially expressed genes observed in the F3 generation of vinclozolin and DDT lineage granulosa cells have been correlated with PCOS and POI.…”

Section: Discussionmentioning

confidence: 99%

Environmental toxicant induced epigenetic transgenerational inheritance of ovarian pathology and granulosa cell epigenome and transcriptome alterations: ancestral origins of polycystic ovarian syndrome and primary ovarian insufficiency

et al. 2018

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Two of the most prevalent ovarian diseases affecting women’s fertility and health are Primary Ovarian Insufficiency (POI) and Polycystic Ovarian Syndrome (PCOS). Previous studies have shown that exposure to a number of environmental toxicants can promote the epigenetic transgenerational inheritance of ovarian disease. In the current study, transgenerational changes to the transcriptome and epigenome of ovarian granulosa cells are characterized in F3 generation rats after ancestral vinclozolin or DDT exposures. In purified granulosa cells from 20-day-old F3 generation females, 164 differentially methylated regions (DMRs) (P < 1 x 10−6) were found in the F3 generation vinclozolin lineage and 293 DMRs (P < 1 x 10−6) in the DDT lineage, compared to controls. Long noncoding RNAs (lncRNAs) and small noncoding RNAs (sncRNAs) were found to be differentially expressed in both the vinclozolin and DDT lineage granulosa cells. There were 492 sncRNAs (P < 1 x 10−4) in the vinclozolin lineage and 1,085 sncRNAs (P < 1 x 10−4) in the DDT lineage. There were 123 lncRNAs and 51 lncRNAs in the vinclozolin and DDT lineages, respectively (P < 1 x 10−4). Differentially expressed mRNAs were also found in the vinclozolin lineage (174 mRNAs at P < 1 x 10−4) and the DDT lineage (212 mRNAs at P < 1 x 10−4) granulosa cells. Comparisons with known ovarian disease associated genes were made. These transgenerational epigenetic changes appear to contribute to the dysregulation of the ovary and disease susceptibility that can occur in later life. Observations suggest that ancestral exposure to toxicants is a risk factor that must be considered in the molecular etiology of ovarian disease.

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Evaluation of the association between GHR exon 3 polymorphism and polycystic ovary syndrome among Han Chinese women

Cited by 7 publications

References 19 publications

Association between the Growth Hormone Receptor Exon 3 Polymorphism and Metabolic Factors in Korean Patients with Acromegaly

Association between the Growth Hormone Receptor Exon 3 Polymorphism and Metabolic Factors in Korean Patients with Acromegaly

A descriptive study on selected growth parameters and growth hormone receptor gene in healthy young adults from the American Midwest

Environmental toxicant induced epigenetic transgenerational inheritance of ovarian pathology and granulosa cell epigenome and transcriptome alterations: ancestral origins of polycystic ovarian syndrome and primary ovarian insufficiency

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