Evaluation of the association between cognitive impairment and the vitamin D levels among community-dwelling Japanese pre-frail elderly individuals

Okuno, Junko; Fukasaku, Takako; Hotta, Kazushi; Yabushita, Noriko; Pei, Liying; Okura, Tomohiro; Tanaka, Kiyoji; Yanagi, Hisako

doi:10.3143/geriatrics.50.515

Cited by 6 publications

(12 citation statements)

References 18 publications

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“…In the current study, the mean vitamin D level was 43.1 nmol/L, which is lower than means in other studies. For example, one study reported a mean of 57.1 nmol/L in a sample of older Japanese adults, and another study detailed mean vitamin D levels from other studies that were higher than those in the current study (44.7–69.0 nmol/L). The lower vitamin D levels reported in the current study and in others on Asian populations highlight the importance of studying vitamin D from a global perspective.…”

Section: Discussioncontrasting

confidence: 47%

“…Other studies had different findings. One study reported no difference in MMSE scores in different vitamin D groups (reporting a negative association using the Short Blessed Test), and another found a negative association only in men in a Japanese sample. The sex interaction term in the current study was not significant, suggesting no sex difference in the sample in the association between vitamin D and cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

“…Another study found no such association in a sample of older Chinese men. In samples with men and women, the results are mixed …”

mentioning

confidence: 99%

“…Vitamin D levels were analyzed in older Chinese men in Hong Kong, and it was found that, although vitamin D levels were inversely related to depression, they were not associated with cognitive impairment . A study of elderly Japanese men observed that those with low vitamin D levels had lower MMSE scores …”

mentioning

confidence: 99%

“…In samples with men and women, the results are mixed. 12,20 In addition to sex, the type of cognitive assessment used in studies affects the relationship between vitamin D levels and cognitive performance. One study 21 highlighted that, although its population's performance on the Short Blessed Test and the Clinical Dementia Rating supported the negative relationship between vitamin D levels and the odds of cognitive impairment, Mini-Mental State Examination (MMSE) scores failed to reveal any cognitive differences between vitamin D groups.…”

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confidence: 99%

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Vitamin D Levels and Cognition in Elderly Adults in China

Chei

Raman

Yin

et al. 2014

J American Geriatrics Society

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Objectives To evaluate the association between vitamin D status and cognitive impairment (CI) in elderly aged 60 years and above Design Cross-sectional cohort study Setting Chinese Longitudinal Healthy Longevity Survey, a community-based cohort study in longevity areas in China Participants Individuals with mean age of 84.9 (± 12.7) (n=2004) Measurements Participants’ cognitive state was evaluated using the Mini-Mental State Examination (MMSE). Vitamin D in plasma was measured using enzyme-linked immunoassay. Results The cross-sectional association between quartiles of plasma vitamin D level and CI (MMSE score <18) was modeled using logistic regressions. Plasma vitamin D levels were lower in individuals with CI compared to those without (31.9 (±15.3) versus 45.6 (±19.6)nmol/L). There was a reverse association between plasma vitamin D and CI. After adjusting for age, gender, chronic conditions, smoking and drinking habits, outdoor activities, depression, and Activities of Daily Living limitations, the association remained significant. The multivariable adjusted odds ratio for lowest versus highest vitamin D levels was 2.15 (1.05–4.41) for CI, and the multivariable odds ratio associated with 1-SD decrement of plasma vitamin D was 1.32 (1.00–1.74) for CI. Conclusion In our sample population, low plasma vitamin D levels were associated with increased odds of CI. Further prospective studies in Asian populations are needed to examine the causal direction of this association.

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Section: Discussioncontrasting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

“…Another study found no such association in a sample of older Chinese men. In samples with men and women, the results are mixed …”

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Vitamin D Levels and Cognition in Elderly Adults in China

Chei

Raman

Yin

et al. 2014

J American Geriatrics Society

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Low serum 25-hydroxyvitamin D increases cognitive impairment in elderly people

et al. 2018

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It has been reported that many elderly people have low serum levels of 25-hydroxyvitamin D [25(OH)D] and that serum 25(OH)D levels may have a relationship with cognitive function. The aim of this study was to examine the relationship between serum 25(OH)D levels and cognitive function in a Japanese population. This cross-sectional study was performed as a part of the Project in Sado for Total Health (PROST). The PROST study evaluated cognitive state and serum vitamin D level from June 2011 to November 2013 for 740 patients (431 men and 309 women). The Mini-Mental State Examination-Japanese version (MMSE-J) and serum 25(OH)D level measurements were used as assessment tools. Cognitive impairment was defined using MMSE-J ≤ 23 as a cutoff. Multiple logistic regression analyses were performed to calculate the odds ratios (ORs) for low MMSE-J scores. The average subject age was 68.1 years, the average MMSE- J score was 25.9, and the average 25(OH)D level was 24.6 ng/mL. Significant ORs for cognitive impairment were observed for both high age and low serum 25(OH)D. The adjusted OR for the lowest versus highest serum 25(OH)D quartiles was 2.70 (95% confidence interval 1.38-5.28, P = 0.0110). Low serum 25(OH)D levels were independently associated with a higher prevalence of cognitive impairment.

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