2020
DOI: 10.17219/acem/118843
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Evaluation of the association between angiotensin converting enzyme insertion/deletion polymorphism and the risk of endometrial cancer in and characteristics of Polish women

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Cited by 8 publications
(8 citation statements)
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“…Moreover, several studies highlight the importance of single nucleotide polymorphisms (SNPs) in the genetic susceptibility, development, and/ or progression of PC 1,5,6,9,10 . Among these polymorphisms, the genetic variants of the Renin‐Angiotensin System (RAS) were well studied in association with cancers 11–16 . RAS includes Angiotensin‐Converting Enzyme ( ACE ), the key effector peptide of RAS, converts angiotensin‐I to angiotensin‐II and splits bradykinin into inactive fragments 11 .…”
Section: Introductionmentioning
confidence: 99%
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“…Moreover, several studies highlight the importance of single nucleotide polymorphisms (SNPs) in the genetic susceptibility, development, and/ or progression of PC 1,5,6,9,10 . Among these polymorphisms, the genetic variants of the Renin‐Angiotensin System (RAS) were well studied in association with cancers 11–16 . RAS includes Angiotensin‐Converting Enzyme ( ACE ), the key effector peptide of RAS, converts angiotensin‐I to angiotensin‐II and splits bradykinin into inactive fragments 11 .…”
Section: Introductionmentioning
confidence: 99%
“… 1 , 5 , 6 , 9 , 10 Among these polymorphisms, the genetic variants of the Renin‐Angiotensin System (RAS) were well studied in association with cancers. 11 , 12 , 13 , 14 , 15 , 16 RAS includes Angiotensin‐Converting Enzyme ( ACE ), the key effector peptide of RAS, converts angiotensin‐I to angiotensin‐II and splits bradykinin into inactive fragments. 11 The alteration of ACE enzyme activity was associated with the development of many diseases such as COVID, 17 , 18 hypertension, and cardiovascular diseases (CVDs), 19 , 20 renal pathology, 21 Alzheimer disease, 22 , 23 polycystic ovarian syndrome, 24 and cancers.…”
Section: Introductionmentioning
confidence: 99%
“…Specifically, ACE produces AngII, and ACE2 degrades AngII to Ang1–7. Some previous studies showed that ACE polymorphism, which was defined in detail by the absence or presence of a 287-bp DNA fragment in intron 16 of the ACE gene, was associated with various heart-related and other diseases such as atherosclerosis ( Sayed-Tabatabaei et al, 2003 ), myocardial infarction ( Cambien et al, 1992 ), ischemic stroke ( Sharma, 1998 ), diabetic nephropathy ( Boright et al, 2005 ), hypertension ( Pachocka et al, 2020 ), endurance exercise ( John et al, 2020 ), and cancer ( Raba et al, 2020 ). Recently, ACE inhibitors have been used to treat hypertension with a lower proportion of critical patients and a lower death rate in COVID-19 patients ( Yang et al, 2020 ).…”
Section: Mainmentioning
confidence: 99%
“…Both angiotensin-converting-enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are commonly used and regarded as safe therapies with few side effects [ 10 ]. However, there is an increasing evidence that long-term drugs affecting the RAAS may have impacts on the risk of cancers [ 12 ], including gynecological cancers [ 13 , 14 , 15 ]. Numerous observational studies on the associations of ARBs and ACEIs with gynecological cancers have produced contradictory findings.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, previous studies demonstrated that women who used ACEIs had decreased rates of gynecologic tract cancer [ 15 ], while others highlighted that individuals with ovarian cancer had higher serum ACEI levels. Circulating ACEIs may be linked to ongoing pathobiologic processes in the development of ovarian cancer [ 17 ] and endometrial cancer [ 14 ]. Some evidence has indicated that RAAS inhibitors may affect angiogenesis, tumor cell proliferation, follicle maturation, cell proliferation, and vascularization in gynecological human tissues both in vitro and in vivo [ 1 , 18 , 19 , 20 , 21 ].…”
Section: Introductionmentioning
confidence: 99%