Evaluation of the association of genetic variants on the chromosomal loci 9p21.3, 6q25.1, and 2q36.3 with angiographically characterized coronary artery disease

Muendlein, Axel; Saely, Christoph H.; Rhomberg, Simone; Sonderegger, Gudrun; S, Loacker; Rein, Philipp; Beer, Stefan; Vonbank, Alexander; Winder, Thomas

doi:10.1016/j.atherosclerosis.2008.10.035

Cited by 33 publications

(31 citation statements)

References 21 publications

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“…A similar observation was made by Horne et al (17), who found that the 9p21.3 genetic variant was not associated with incident events or prevalent myocardial infarction in a population of patients undergoing coronary angiography, although it did predict a diagnosis of coronary artery disease. The 9p21.3 region has been associated with the calcium score (5,14), severe premature atherosclerosis (5), the prevalence of angiographic coronary artery disease (18,22), and the progression of carotid atherosclerosis (19). In keeping with these findings, we observed an association between the 9p21.3 genetic variant rs1333040 and the prevalence of coronary artery disease at the time of the coronary angiography performed during the index hospitalization.…”

Section: Discussionsupporting

confidence: 83%

Influence of 9p21.3 Genetic Variants on Clinical and Angiographic Outcomes in Early-Onset Myocardial Infarction

Ardissino

Berzuini²,

Merlini

et al. 2011

Journal of the American College of Cardiology

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Section: Discussionsupporting

confidence: 83%

Influence of 9p21.3 Genetic Variants on Clinical and Angiographic Outcomes in Early-Onset Myocardial Infarction

Ardissino

Berzuini²,

Merlini

et al. 2011

Journal of the American College of Cardiology

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“…The observed frequencies of the G-and C-alleles were 0AE59 and 0AE41, respectively, which is in accordance with the previous reports [3,8].…”

Section: Resultssupporting

confidence: 94%

Forearm vasodilator reactivity in homozygous carriers of the 9p21·3 rs1333049 G>C polymorphism

Mittermayer

Wagner

Schmidt

et al. 2010

Eur J Clin Investigation

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“…Genetic variation in this region has also been shown to be associated with severe premature atherosclerosis 29) , angiographic CAD 30,31) and the risk of progression of carotid atherosclerosis 32) . Variations in the 9p21 region can affect the expression of proximal genes.…”

Section: Discussionmentioning

confidence: 99%

The Severity of Internal Carotid Artery Stenosis is Associated with the Cyclin-Dependent Kinase Inhibitor 2A Gene Expression

Bayoğlu

Arslan

Göde

et al. 2014

JAT

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Aim: The INK4b-ARF-INK4a locus in the chromosome 9p21 region is known to play an important role in the development of atherosclerosis. The INK4/ARF transcript p16INK4a inhibits the activity of the cyclin-dependent kinases CDK4/CDK6 and arrests cell-cycle progression. CDK inhibitors also regulate G1/S phase progression in vascular smooth muscle cells (VSMCs) and may modulate the early stages of atherosclerosis. Therefore, we aimed to study the expression of the INK4/ARF locus genes CDKN2A and CDKN2BAS in order to examine the p16 INK4a protein expression and the level of cell proliferation in carotid plaques and saphenous tissue samples. Methods: A total of 50 patients (33 symptomatic subjects and 17 asymptomatic subjects) with carotid atherosclerosis (CA) were studied. The CDKN2A and CDKN2BAS gene expression levels were determined using quantitative real-time polymerase chain reaction (qRT-PCR). All tissue sections were also analyzed for the p16INK4a and proliferating cell nuclear antigen (PCNA) protein expression using immunohistochemistry (IHC). Results: The CDKN2A gene expression was significantly higher in the carotid plaques than in the saphenous tissues (p= 0.009), whereas no such differences were observed in the CDKN2BAS transcripts (p = 0.157). The carotid plaque CDKN2A mRNA levels were higher in the symptomatic patients than in the asymptomatic patients (p = 0.050); this finding was also associated with the severity of internal carotid artery (ICA) stenosis (p=0.034). The p16INK4a immune (＋) cell counts in the carotid plaques were higher in the symptomatic patients than in the asymptomatic patients (p = 0.056), as was the cell proliferation index (p=0.001). Conclusions: An increased CDKN2A gene expression in carotid plaques may increase the severity of ICA stenosis, thus raising the risk of atherosclerosis and contributing to the development of symptoms. In addition, the p16INK4a expression is associated with carotid atherosclerosis in various patient subgroups.J Atheroscler Thromb, 2014; 21:659-671.

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Evaluation of the association of genetic variants on the chromosomal loci 9p21.3, 6q25.1, and 2q36.3 with angiographically characterized coronary artery disease

Cited by 33 publications

References 21 publications

Influence of 9p21.3 Genetic Variants on Clinical and Angiographic Outcomes in Early-Onset Myocardial Infarction

Influence of 9p21.3 Genetic Variants on Clinical and Angiographic Outcomes in Early-Onset Myocardial Infarction

Forearm vasodilator reactivity in homozygous carriers of the 9p21·3 rs1333049 G>C polymorphism

The Severity of Internal Carotid Artery Stenosis is Associated with the Cyclin-Dependent Kinase Inhibitor 2A Gene Expression

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