Evaluation of the Behavior in Water of a Biomaterial Composed of Different Phases of Calcium Phosphate

Abstract

The synthesis of calcium phosphates of biological interest has been one of the strategies studied in the field of tissue regeneration due to its similarity to the inorganic components of bone. One of the aspects studied has been the process of dissolution of calcium phosphates in water and physiological serum, with the aim of being able to know everything related to the behavior of these materials during the bone regeneration process. The objective of this work was to evaluate the behavior in the water of a biomaterial composed of a three-phase mixture of calcium phosphate for use in tissue regeneration. Three phases of calcium phosphate were synthesized. A biomaterial with a mixture of these phases was elaborated and placed in water at 37ºC. The amount of calcium and phosphorus released was determined over time. The treated samples were evaluated by X-ray diffractometry and infrared spectrometry. The results of this study demonstrated that for calcium, the release overtime was not significant due to the reaction of these ions in solution with phosphate ions and the subsequent precipitation in the studied material. While for phosphorus, the release over time was significant. The results corroborate that the use of a triphasic mixture of calcium phosphates allows us to produce a biomaterial suitable for use as a material in tissue regeneration.