Evaluation of the benefit and use of the new terminology in endometrial cytology reporting system

Shinagawa, Akiko; Kurokawa, Tetsuji; Yamamoto, Makoto; Onuma, Toshimichi; Tsuyoshi, Hideaki; Chino, Yoko; Iwasaki, Kazumi; Mori, Masaki; Imamura, Yoshiaki; Yoshida, Yoshio

doi:10.1002/dc.23901

Cited by 11 publications

(7 citation statements)

References 16 publications

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“…In this report, we have shared the advantages of the LBC method applied to the cytologic diagnosis of endometrial lesions. The success of "TYS reporting format" will depend on the pathology and gynecologic oncology communities working collectively to improve this diagnostic standardization and to optimize its impact on patient care [78].…”

Section: Resultsmentioning

confidence: 99%

A Diagnostic Approach to Endometrial Cytology by Means of Liquid-Based Preparations

Norimatsu¹,

Yanoh²,

Hirai³

et al. 2019

Acta Cytologica

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The adoption of endometrial cytology as a diagnostic procedure has been hampered in the past by difficulties arising in interpreting the cellular findings due to a number of factors (such as excess blood, cellular overlapping, and the complex physiology of endometrium). Recently, the use of liquidbased cytology (LBC), with its ability to remove blood and mucus and to distribute cells uniformly in a thin layer on the slide, has provided an opportunity to reevaluate the role of endometrial cytology. LBC samples are easier to screen compared to conventional ones, due to a smaller screening area and an excellent quality of cell preparations. LBC by using peculiar cytoarchitectural features is a useful tool in the cellular diagnosis and follow-up of abnormalities, which, how-ever, remains complementary to histopathology and to the emerging molecular diagnostic cytopathology. This review discusses these various entities and takes into consideration the ancillary techniques that may be useful in the diagnostic procedure. Herein, we also summarize the process and rationale by which updates were made to the standardized terminology in 2018 and outline the contents of the new Bethesda-style classification (the Yokohama system) for the endometrial cytology.

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Section: Resultsmentioning

confidence: 99%

A Diagnostic Approach to Endometrial Cytology by Means of Liquid-Based Preparations

Norimatsu¹,

Yanoh²,

Hirai³

et al. 2019

Acta Cytologica

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“…The new terminology for endometrial cytology has been introduced and now TYSEC system is usefully utilized. [1][2][3][4][5] However, diagnosis of gray zone category, ATEC, especially ATEC-US implies that clinicians would perform unnecessary biopsies. Accurate cytological diagnosis is required to maximize the merit of cytology, which seems less harmful than biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have shown that nearly 10% of the cases assigned to cytological ATEC-US category had corresponding malignant histology. [3][4][5] Although cytological gray zone category intrinsically has some amount of corresponding malignant histology, if it is large, it could cause a problem for managing patients with a cytological diagnosis of ATEC-US. Therefore, it would be ideal to minimize the number of cytological diagnosis of ATEC.…”

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confidence: 99%

Application of immunocytochemical and molecular analysis of six genes in liquid‐based endometrial cytology

Munakata

Yamamoto

2021

Diagnostic Cytopathology

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Background: The Yokohama System of Endometrial Cytology has been used for reporting endometrial cytology, which includes gray zone category, atypical endometrial cells (ATEC), subdivided into ATEC-US and ATEC-AE. ATEC-US has been reported to be correlated with malignancy in nearly 10% of the cases. For accurate diagnosis, application of ancillary techniques on endometrial cytology was investigated.Methods: Thirty-seven liquid based cytological specimens (SurePath™) with diagnosis of ATEC or malignant which have corresponding histological specimens, were subjected to immunocytochemical analysis for β-catenin, ARID1A, and PTEN. Hot spots of mutations for KRAS, BRAF and PIK3CA were evaluated by using i-densy system (ARKRAY).Results: In endometrial samples with the diagnosis of ATEC and malignant, aberrant gene expressions and/or gene mutations for β-catenin, ARID1A, PTEN, KRAS, BRAF,

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“…21 However, several studies showed that increasing number of cases in gray zone category, especially ATEC-US in TYSEC, could cause problem in managing patients. [22][23][24] To solve the problem, a new approach to improve diagnostic accuracy have been expected. accuracy of endometrial carcinoma using thin-layer samples.…”

Section: Diagnostic Classification Of Endometrial Cytologymentioning

confidence: 99%

Diagnostic value of endometrial cytology and related technology

Munakata

2022

Diagnostic Cytopathology

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Background Endometrial cytology is not much popular in the world, but is commonly used in a few countries. Although cytomorphological evaluation of endometrial cytology is complicating, recent advance in technology helps improve diagnostic accuracy. In addition, new reporting system, The Yokohama System, has been introduced as a standard reporting system resembling The Bethesda System of the uterine cervical cytology. Although sample standardization is one of the causes in diagnostic problem, it was solved by liquid‐based cytology (LBC) technology. In addition, standardized diagnostic algorithm by cytomorphological assessment of LBC samples, the Osaki Study Group (OSG) method, was recently proposed as a reliable and reproducible method. LBC can be utilized for ancillary methods. Application of immunocytochemistry and molecular technology on endometrial cytology samples has been studied to improve diagnostic accuracy. Recent progress of molecular technology has revealed many driver gene mutations in endometrial cancer and its precursors. Surprisingly, many studies revealed that even normal endometrial tissue had driver gene mutations. Conclusion Based on the recent advance in knowledge of molecular profile of endometrial lesions and normal endometrial tissue, endometrial cytology will gain much power in clinical usefulness.

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Evaluation of the benefit and use of the new terminology in endometrial cytology reporting system

Abstract: These data suggest that patients with ATEC-US results can be followed up for at least three months, and the introduction of the NTEMC system decreased the number of unnecessary endometrial biopsies.

Cited by 11 publications

References 16 publications

A Diagnostic Approach to Endometrial Cytology by Means of Liquid-Based Preparations

A Diagnostic Approach to Endometrial Cytology by Means of Liquid-Based Preparations

Application of immunocytochemical and molecular analysis of six genes in liquid‐based endometrial cytology

Diagnostic value of endometrial cytology and related technology

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