Evaluation of the blood coagulation-fibrinolysis system in patients undergoing regular hemodialysis.

Ishii, Yoshitaka; Kanai, Hideo; Fujizuka, Naoto; Maezawa, Akira; Tsuchida, A; Wakamatsu, Ryoji; Yano, Shintaro; Naruse, Takuji

doi:10.4009/jsdt.27.1049

Cited by 6 publications

(9 citation statements)

References 20 publications

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“…This could be due to the lack of activation of coagulation or, less likely, to augmented clearance of increased markers of coagulation activation. Our results are not in agreement with the majority of (older) studies, which mostly showed activation of coagulation after haemodialysis procedure, but are in line with newer studies that showed lack or only low activation of coagulation during haemodialysis procedure [6,7,14,18] . Very likely, this seems to be due to the differences between previously used and improved, currently used modern procedures of haemodialysis by biocompatible membranes and better anticoagulation with low-molecularweight heparins.…”

Section: Discussioncontrasting

confidence: 43%

“…Thus, fi brinolysis is evidently activated during the modern haemodialysis procedure. The role of haemodialysis on fi brinolytic parameters has been investigated in several studies [7][8][9][10][11][12][13][14] . It seems that increased activation of fi brinolysis is the consequence of extra-corporeal circulation and that it is related to dialysis membrane biocompatibility [12,13] .…”

Section: Discussionmentioning

confidence: 99%

“…During haemodialysis, platelets, coagulation and fi brinolytic systems could be importantly affected due to several known (velocity of procedure, type of membrane, artifi cial vascular access, circuit composition, and the type of anticoagulation) and unknown factors [12][13][14][15][16][17][18][19] . The aim of the present study was to explore the effect of the currently used, modern procedure of haemodialysis using synthetic membranes and low-molecular-weight heparin as anticoagulant on platelets, coagulation and fibrinolysis.…”

Section: Discussionmentioning

confidence: 99%

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The Influence of the Haemodialysis Procedure on Platelets, Coagulation and Fibrinolysis

Šabovič¹,

Salobir²,

Zupan³

et al. 2005

Pathophysiol Haemos Thromb

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In end-stage renal disease, in particularly when treated with haemodialysis, the function of platelets, coagulation and fibrinolytic systems can be disturbed, thus contributing to either thrombotic or bleeding complications. It is important to know whether the currently used haemodialysis procedure itself (by biocompatible membranes and better anticoagulation with nandroparin) affects platelets, coagulation or fibrinolysis. In 15 patients who had been treated with chronic haemodialysis, we measured and compared platelet aggregation (induced by adenosine diphosphate, collagen and epinephrine), the markers of coagulation and fibrinolysis activation (thrombin-antithrombin complexes, thrombin fragments F1+2, D-dimer), and fibrinolytic parameters, i.e. fibrinogen, plasminogen, tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 1 antigen and activity, before and immediately after the regular haemodialysis sessions. We did not find differences between pre- and post-haemodialysis platelet aggregation induced with all agents. Markers of coagulation and fibrinolysis activation remained unchanged during the process of haemodialysis. However, in post-haemodialysis samples, t-PA activity was significantly increased. Other fibrinolytic parameters remained unchanged. In conclusion, our results showed that the current technique of haemodialysis procedure does not affect platelet aggregation or activate coagulation, and therefore, does not contribute to a thrombotic tendency. However, it does directly affect fibrinolysis through activation of t-PA, which might be clinically relevant since this could increase the bleeding tendency in some haemodialysis patients.

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Section: Discussioncontrasting

confidence: 43%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Influence of the Haemodialysis Procedure on Platelets, Coagulation and Fibrinolysis

Šabovič¹,

Salobir²,

Zupan³

et al. 2005

Pathophysiol Haemos Thromb

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“…Increased activated factor VII and factor VIII levels have been previously reported in hemodialyzed patients [1,2]. The cardiovascular risk has been associated with high factor VII levels [3].…”

mentioning

confidence: 97%

Hypercoagulopathy in a Hemodialysis Patient: Are Elevations in Factors VII and VIII Effective?

Baskın¹,

Duman²,

Beşbaş³

et al. 1999

Nephron

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“…[1][2][3][4] One of the undesirable phenomena that lead to a failure of hemodialysis is blood coagulation in the tubes. [5][6][7][8][9] This is caused mainly by the hemoagglutination activation protein. This protein makes white blood cells and platelets adhere to the surface of the membrane at the beginning of the coagulation process, thus impeding the successful outcome of dialysis.…”

mentioning

confidence: 99%

Analysis of Serum Proteins Adsorbed to a Hemodialysis Membrane of Hollowfiber Type by Thermal Lens Microscopy

et al. 1999

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To analyze serum proteins adsorbed to a hemodialysis membrane, immunostaining with colloidal gold and thermal-lens microscopy were employed. A total of 14 types of hemodialysis membranes were tested. The cross sections of the membranes were stained with fluorescent antibodies. Observations of these specimens using a laser microscope revealed that serum proteins, such as albumin and immuno globulins, tended to adsorb into the inner wall of these membranes. The degree of adsorption of serum proteins varied according to various conditions, such as what materials the membranes were made of or what proteins were adsorbed. For a better quantitative analysis of these proteins, the membranes were stained with immunogold and were observed by a thermal lens microscope. Colloidal gold coated with various antihuman serum proteins was used for the staining, and the quantity of colloidal gold was measured with a thermal-lens microscope. The quantity of colloidal gold, coated with anti-human sera antibody, gradiently decreased from the inner to the outer wall of the membrane. Probably, proteins with larger molecules were adsorbed to the inner parts, and those with smaller molecules were adsorbed to the outer parts of the membrane wall. High-resolution thermal-lens microscopy makes possible the sensitive detection of localized proteins adsorbed to a membrane without extracting it. Thus, the analysis of adsorbed proteins should serve to determine the adaptability of medical appliances to the human body and should also be helpful to a retrospective analysis of substances like drugs which are conjugated to the serum proteins.

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Evaluation of the blood coagulation-fibrinolysis system in patients undergoing regular hemodialysis.

Cited by 6 publications

References 20 publications

The Influence of the Haemodialysis Procedure on Platelets, Coagulation and Fibrinolysis

The Influence of the Haemodialysis Procedure on Platelets, Coagulation and Fibrinolysis

Hypercoagulopathy in a Hemodialysis Patient: Are Elevations in Factors VII and VIII Effective?

Analysis of Serum Proteins Adsorbed to a Hemodialysis Membrane of Hollowfiber Type by Thermal Lens Microscopy

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