Evaluation of the Bone-Regenerating Effects of Two Anorganic Bovine Bone Grafts in a Critical-Sized Alveolar Ridge Defect Model

Kim, David M.; Hong, Heather; Lin, Jerry Ching-Yi; Nevins, Myron

doi:10.11607/prd.3305

Cited by 6 publications

(3 citation statements)

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“…They found a significant increase in bone density when using inorganic bone combined with resorbable collagen membrane evaluated by CT compared to only bone or unfilled control. It has been reported that lack of a barrier membrane may have a negative bone regeneration effect due to lack of graft containment and wound stabilization (D. M. Kim, Hong, et al, 2017). Therefore, the bone regenerative effect of the ABCcolla ® was done in combination with a commercial membrane, Bio-Gide ® , in that clustered randomization could result in loss of efficiency, particularly in terms of effective sample size (Hauck et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

Evaluating the bone‐regenerative role of the decellularized porcine bone xenograft in a canine extraction socket model

Chen

Hsieh³

et al. 2020

Clinical & Exp Dental Res

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Objective: To evaluate the efficacy of a novel decellularized porcine bone xenograft, produced by supercritical carbon dioxide extraction technology, on alveolar socket healing after tooth extraction compared to a commercially available deproteinized bovine bone (Bio-Oss ® ).Materials and methods: Nine dogs (about 18 months old and weighing between 20 kg and 30 kg) underwent extractions of lower second to fourth premolars, bilaterally. The dogs were randomly selected and allocated to the following groups: Group 1: control unfilled socket; Group 2: socket filled with decellularized porcine bone xenograft (ABCcolla ® ) and covered by a commercially available porcine collagen membrane (Bio-Gide ® ); Group 3: socket filled with Bio-Oss ® and covered by Bio-Gide ® membrane. One dogs from each group was sacrificed at 4-, 12-, and 24-week to evaluate the socket healing after tooth extraction. The mandible bone blocks were processed without decalcification and specimens were embedded in methyl methacrylate and subjected to histopathology analyses to evaluate the bone regeneration in the extraction sockets.Results: At 24-week after socket healing, ABCcolla ® treated defects demonstrated significantly higher histopathology score in new bone formation and bone bridging, but significantly lower score in fluorescent labeling than those of the Bio-Oss ® . In the microphotographic examination, decellularized porcine bone xenograft showed similar characteristics of new bone formation to that of Bio-Oss ® . However, there was significantly less remnant implant materials in the decellularized porcine bone xenograft compared to the Bio-Oss ® group at 24-week. Thus, the decellularized porcine bone graft seems to have promising bone regeneration properties similar to that of

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Section: Discussionmentioning

confidence: 99%

Evaluating the bone‐regenerative role of the decellularized porcine bone xenograft in a canine extraction socket model

Chen

Hsieh³

et al. 2020

Clinical & Exp Dental Res

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“…No significant differences were observed between the experimental groups regarding graft resorption, bony integration, percentage of mineralized bone volume, and density based on radiographic analysis. Histologic examination similarly revealed no discernible differences between the two groups, although there was a non-significant trend towards increased bone formation for InterOss® compared to Bio-Oss® after 8 and 12 weeks [ 73 ]. In another study, bone level tapered implants (BLT) were inserted into the mandibles of 10 minipigs, where circumferential defects measuring 4 mm in depth and 2 mm in width were created around the implants.…”

Section: Resultsmentioning

confidence: 99%

A comparative analysis of particulate bovine bone substitutes for oral regeneration: a narrative review

Pabst,

Becker,

Götz

et al. 2024

Int J Implant Dent

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Purpose Particulate bovine bone substitutes (BS) are commonly used in oral regeneration. However, more literature is needed focusing on comparative analyses among various particulate bovine BS. This study evaluates pre-clinical and clinical data of different particulate bovine BS in oral regeneration. Methods A narrative review was conducted by screening the PubMed database Included in the review were pre-clinical and clinical studies until 2024 comparing a minimum of two distinct particulate bovine BS. In addition to examining general data concerning manufacturing and treatment processes, biological safety, physical and chemical characteristics, and graft resorption, particular emphasis was placed on assessing pre-clinical and clinical data related to ridge preservation, sinus floor elevation, peri-implant defects, and various forms of alveolar ridge augmentation utilizing particulate bovine BS. Results Various treatment temperatures ranging from 300 to 1,250 °C and the employment of chemical cleaning steps were identified for the manufacturing process of particulate bovine BS deemed to possess biosecurity. A notable heterogeneity was observed in the physical and chemical characteristics of particulate bovine BS, with minimal or negligible graft resorption. Variations were evident in particle and pore sizes and the porosity of particulate bovine BS. Pre-clinical assessments noted a marginal inclination towards favorable outcomes for particulate bovine BS subjected to higher treatment temperatures. However, clinical data are insufficient. No distinctions were observed regarding ridge preservation, while slight advantages were noted for high-temperature treated particulate bovine BS in sinus floor elevation. Conclusions Subtle variances in both pre-clinical and clinical outcomes were observed in across various particulate bovine BS. Due to inadequate data, numerous considerations related to diverse particulate bovine BS, including peri-implant defects, must be more conclusive. Additional clinical studies are imperative to address these knowledge gaps effectively. Graphical abstract

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“…A previous study comparing sintered and non-sintered bovine bone blocks demonstrated that the sintered bovine bone block exhibited significantly less bone resorption than the non-sintered one [ 34 ]. Kim et al [ 35 ] conducted a study on 2 particulate DBBMs (Bio-Oss vs. InterOss) in a dog model and reported that the materials had similar bone regeneration properties. Park [ 36 ] also described the basic characteristics of 3 commercially available bone substitutes: Bio-Oss, BBP (Oscotec, Seoul, Korea), and Osteograft (DIZG, Berlin, Germany).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of regeneration after the application of 2 types of deproteinized bovine bone mineral to alveolar bone defects in adult dogs

Lee

Kim

et al. 2022

J Periodontal Implant Sci

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Purpose The aim of this study was to evaluate the preclinical results of 2 types of commercially available deproteinized bovine bone mineral (DBBM) when applied to alveolar bone defects in dogs. Methods This study was conducted using 6 beagles. Alveolar defects in the mandible were formed and filled with 2 DBBMs produced by a similar procedure. Defects were randomly assigned to be filled using DBBM 1 or 2. All defects were covered with a collagen membrane and had a healing period of 12 weeks. After the dogs were sacrificed, histological, histomorphometric, and linear/volumetric analyses were performed. Results Both DBBM groups showed similar histological findings, demonstrating that bone remodeling had occurred and new bone had formed. The residual bone particles were surrounded by newly formed vital bone. In the histomorphometric analysis, the ratio of the area of vital bone and residual bone substitute in DBBM 2 (38.18% and 3.47%, respectively) was higher than that of DBBM 1 (33.74% and 3.41%, respectively), although the difference was not statistically significant. There were also no statistically significant differences between both groups in linear and volumetric analyses using micro-computed tomography scans and digitized images of dental casts. Conclusions In the present study, DBBM 1and 2, which were produced by similar processes, showed similar results in histological, histomorphometric, and volumetric analyses. Further studies are needed to identify more specific differences between the 2 DBBMs.

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Evaluation of the Bone-Regenerating Effects of Two Anorganic Bovine Bone Grafts in a Critical-Sized Alveolar Ridge Defect Model

Cited by 6 publications

References 0 publications

Evaluating the bone‐regenerative role of the decellularized porcine bone xenograft in a canine extraction socket model

Evaluating the bone‐regenerative role of the decellularized porcine bone xenograft in a canine extraction socket model

A comparative analysis of particulate bovine bone substitutes for oral regeneration: a narrative review

Evaluation of regeneration after the application of 2 types of deproteinized bovine bone mineral to alveolar bone defects in adult dogs

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