Evaluation of the brain, renal, and hepatic effects of flunixin meglumine, ketoprofen, and phenylbutazone administration in Iranian fat-tailed sheep

Mozaffari, Ali Asghar; Derakhshanfar, Amin

doi:10.1007/s11250-011-9866-5

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…causes increased glial cells, vascular congestion, vasogenic edema, cellular edema, infiltration of inflammatory cells in the meninges and the increase and clustering of glial cells around neurons, Satellitosis. Our results were similar to what the researchers reported [19,57,58]. When xylazine and ketamine are used to anesthetize monkeys, the results include rapid neurological damage to the brain and spinal cord…”

Section: Histopathological Effects In Liversupporting

confidence: 91%

Effect of Xylazine Administration on Ketoprofen Toxicity in Mice

Khalil

Al-Zubaidy

Mousa

2023

Egyptian Journal of Veterinary Sciences

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T HE goal of our study was to assess the influence of xylazine on the toxicity of ketoprofen in mice, then we determined the effect of co-administration of xylazine and ketoprofen on neurobehavioral toxicity and liver and kidney function as well as histopathological effects after repeated daily administration for 20 days. The LD 50 of ketoprofen & xylazine were respectively (375mg/kg, 75 mg/kg) respectively. The injection of ketoprofen alone at a dose of (0.126 mg/ kg) & ketoprofen & xylazine together at a dose of (0.663 mg/kg) caused the crossed squares & rearing to decline significantly. This was accompanied by a significant increase in the time it took the mouse to return to its normal position and a significant decline in the frequency of head poking. On the tenth and twenty-fifth day of administration of ketoprofen at (71.95 mg/ kg) & xylazine at (14.156 mg/kg i.p) there was a significant elevation in the concentration of liver enzymes(AST& ALT) & kidney function (Creatinine and uric acid ), as well as causing histological changes in the liver, kidney & brain. Our findings reveal that the xylazine caused an exacerbation of ketoprofen toxicity which appear as a depressant effect on the CNS , liver and kidney, furthermore histopathological changes in the liver, kidney, and brain.

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Section: Histopathological Effects In Liversupporting

confidence: 91%