Evaluation of the Burden and Intervention Strategies of TB-HIV Co-Infection in West Africa

E, Akwafuo Sampson; Abah, Theresa; R, Oppong Joseph

doi:10.23937/2474-3658/1510143

Cited by 7 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HIV infection has emerged as the principal cause of human immunodepression exposing people living with HIV to opportunistic diseases such as Mtb . The geographical overlapping of the two diseases had increased the number of cases of HIV/TB co-infection causing an immense and continuous burden on public health systems, mostly in Low and Middle Income Countries (LMIC) [ 1 ]. In fact, people living with HIV are about 30 times more likely to develop active TB, due to compromised immunity [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Plasma IL-33 levels and immune activation in HIV-TB coinfection: a cross-sectional study in Yaoundé, Cameroon

Ghislain,

Mbe,

Ngogang

et al. 2023

Pan Afr Med J

View full text Add to dashboard Cite

Introduction HIV-1 and Mtb are characterized by immune activation and unbalances production of cytokines, but the expression of IL33 in HIV/TB coinfection remain understudied. This study aimed to evaluate the level of IL-33 in plasma of HIV and M. tuberculosis (HIV/TB) coinfected patients compared to patients with respective mono infections in Yaoundé. Methods a cross-sectional study was conducted among patients attending the pneumology service and HIV treatment center of the Yaoundé Jamot Hospital. Plasma samples of 157 HIV/TB coinfected patients (n =26, 50% males and 50% females, mean age 39), HIV-1 monoinfected patients (n = 41, 41% males and 59% females, mean age 35), TB monoinfected patients (n = 48, 56% males and 44% females, mean age 37) and healthy controls (n = 42, 29% males and 71% females, mean age 32) were examined by enzyme-linked immunoassay (ELISA) to detect the levels of IL-33 cytokine. Results plasma level of IL-33 were higher in HIV/TB coinfected (33.1±30.9 pg/ml) and TB monoinfected individuals (15.1±2.9 pg/ml) compared to healthy controls (14.0±3.4 pg/ml) and could not be detected in most of the HIV-1 monoinfected individuals (12.6±8.7 pg/ml). Interestingly, the increased plasma level of IL-33 in HIV/TB coinfected patients showed a statistically significant difference between healthy controls (33.1±30.9 pg/ml vs 14.0±3.4 pg/ml, P<0.0001) and HIV-1 monoinfected patients (33.1±30.9 pg/ml vs 12.6±8.7 pg/ml, P=0.0002). We further found that IL-33 was higher in patients with high viral load group (40.6±59.7 pg/ml vs 12.6±1.8 pg/ml), P= 0.47) whereas patients under highly active antiretroviral therapy (HAART) showed decreased level of IL-33 concentration as the number of years under ART increased. Our data showed a positive association between plasma IL-33 and viral load in the context of HIV/TB coinfection in our study population with a positive Pearson coefficient of r=0.21. Conclusion this study indicates that plasma level of IL-33 differs among HIV/TB coinfected patients and respective monoinfections patients. The increased level of plasma IL-33 reveals that IL-33 measurement in HIV-1 monoinfected patients may represent an early predictor of development of tuberculosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Plasma IL-33 levels and immune activation in HIV-TB coinfection: a cross-sectional study in Yaoundé, Cameroon

Ghislain,

Mbe,

Ngogang

et al. 2023

Pan Afr Med J

View full text Add to dashboard Cite

show abstract

“…TB has been described as one of the diseases leading to death, and Nigeria as a nation is among the countries leading in TB and TB/HIV co-infection [2]. It was further shown that 8% of global cases of TB are found in Africa first approximately 2 billion cases.…”

Section: Introductionmentioning

confidence: 99%

Sensitivity Analysis of Mathematical Modeling of Tuberculosis Dynamics with a Control Measure

S.Y.,

S.S.

2023

African Journal of Mathematics and Statistics Studies

View full text Add to dashboard Cite

Tuberculosis is a global threat to human existence. A model to investigate the transmission of tuberculosis was constructed and analysed. The threshold quantity ( R_0) that predicts the existence or extinction of the disease in a population was computed. It was found that the local stability is asymptotically stable when the basic reproduction number is less than unity at the disease-free – equilibrium point. A Lyapunov function was constructed in order to analyse the global stability which was proved to be globally asymptotically stable when the threshold quantity is less or equal to unity. Sensitivity analysis was conducted on the basic reproduction number in order to determine the parameters of the model that are most sensitive as a way to deduce suitable control measures. Numerical simulations are carried out, discussions were made and results are presented in graphical forms.

show abstract

Harmonize: A Comprehensive Patient and Provider Connectivity Solution for the Management of Mental Disorders

Pieterse

Akwafuo

2022

Proceedings of Seventh International Congress on Information and Communication Technology

View full text Add to dashboard Cite

Evaluation of the Burden and Intervention Strategies of TB-HIV Co-Infection in West Africa

Cited by 7 publications

References 18 publications

Plasma IL-33 levels and immune activation in HIV-TB coinfection: a cross-sectional study in Yaoundé, Cameroon

Plasma IL-33 levels and immune activation in HIV-TB coinfection: a cross-sectional study in Yaoundé, Cameroon

Sensitivity Analysis of Mathematical Modeling of Tuberculosis Dynamics with a Control Measure

Harmonize: A Comprehensive Patient and Provider Connectivity Solution for the Management of Mental Disorders

Contact Info

Product

Resources

About