Evaluation of the Buserelin Stimulation Test in Diagnosing Gonadotropin Deficiency in Males with Delayed Puberty

Inhibin B plus LH vs GnRH agonist test for distinguishing constitutional delay of growth and puberty from isolated hypogonadotropic hypogonadism in boys

“…This is important because cut‐off values in general are only valid for the age and maturation stage of the boys tested and for the assays used. A previous study, using buserelin as the GnRHa and a similar immunoassay, had very comparable settings with respect to age and pubertal stage and reported a very similar cut‐off for the LH (4 h) value of 5·0 IU/l . With respect to inhibin B, we confirmed the diagnostic strength of this parameter for distinguishing HH from CDGP in prepubertal boys, as reported by Coutant et al .…”

Comparison of Detection of Normal Puberty in Boys by a Hormonal Sleep Test and a Gonadotropin-Releasing Hormone Agonist Test

“…Our data across the pubertal transition are consistent with published data on the distinction of constitutional delay of puberty from gonadotropin deficiency (35,36). The 90% population limits we demonstrate in young prepubertal children may also provide guidance in the management of early puberty in boys (37).…”

Potential diagnostic utility of intermittent administration of short-acting gonadotropin-releasing hormone agonist in gonadotropin deficiency

“…GnD males responded to GnRHag administration at 5-day intervals with significant potentiation of LH release, but the LH response was subnormal and transient, testosterone did not increase, and the FSH-predominance of severe GnD (9, 19) persisted. One-year’s treatment of a patient with partial GnD, altering the interval of GnRHag administration and varying the dosage by ten-fold, did not lead to sufficiently sustained repetitive LH and FSH responses to normalize testosterone levels or to correct azospermia.…”