Evaluation of the C-reactive protein serum levels in periodontitis patients with or without atherosclerosis

Thakare, Kaustubh Suresh; Deo, Vikas; Bhongade, Manohar L

doi:10.4103/0970-9290.70787

Cited by 22 publications

(10 citation statements)

References 20 publications

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“…Subjects with concentrations more than 3 mg/l in serum CRP are considered to be at higher a risk for future cardiovascular diseases and events. [101112] After controlling for established risk factors which contribute to the elevation of CRP levels, increased levels of CRP persisted among individuals with the extensive periodontal disease. [1314]…”

Section: Introductionmentioning

confidence: 99%

Evaluation of serum c-reactive protein levels in subjects with aggressive and chronic periodontitis in comparison with healthy controls: A clinico-biochemical study

Bolla

Kumari

Munnangi

et al. 2017

Int J App Basic Med Res

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Aim:Evaluation and comparison of serum C-reactive protein (CRP) levels in subjects with chronic and aggressive periodontitis.Materials and Methods:Based on the periodontal status, 45 subjects were selected and divided into three groups. Group I – subjects with clinically healthy periodontium, Group II – generalized aggressive periodontitis (GAP), and Group III – chronic periodontitis (CP). Blood samples were collected from subjects for measurement of CRP. Periodontal parameters include plaque index (PI), gingival index, bleeding index (BI), probing pocket depth (PPD), and clinical attachment loss (CAL) were assessed. CRP levels were assessed by means of a commercially available high sensitivity-CRP enzyme immunoassay kit.Results:CRP levels were increased in Group III (6.0671 ± 3.15639 mg/L) and Group II subjects (4.5453 ± 2.88116 mg/L) compared to the Group I (1.0180 ± 0.94069 mg/L). CRP levels showed a positive correlation with all clinical parameters in Group I subjects. BI (r = 0.073), PI (r = 0.120) showed a positive correlation with CRP level in Group II and a positive correlation was also seen for PI (r = 0.492), PPD (r = 0.340), CAL (r = 0.160), and CRP level in Group III subjects.Conclusion:The mean CRP levels were found to be greater in CP compared to GAP subjects, but there was no statistically significant difference.

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Section: Introductionmentioning

confidence: 99%

Evaluation of serum c-reactive protein levels in subjects with aggressive and chronic periodontitis in comparison with healthy controls: A clinico-biochemical study

Bolla

Kumari

Munnangi

et al. 2017

Int J App Basic Med Res

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“…This could be due to resolution of inflammation by nonsurgical periodontal therapy. These results were in accordance with the studies done by Correa et al .,[17] Oliveria et al ., (2011)[13] Radafshar et al ., (2010)[15] Noack et al .,[5] Thakare et al .,[18] Gomes-Filho et al .,[19] Pitiphat et al .,[20] Herrera et al . [21] To assure greater reliability of the findings high sensitivity of the immunoturbidometry method used to assess hs-CRP, being capable of detecting variations of even 0.2 mg/L.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of nonsurgical periodontal therapy in chronic periodontitis patients with anemia by estimating hematological parameters and high-sensitivity C-reactive protein levels

et al. 2014

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Background:Periodontal tissues mount an immune inflammatory response to bacteria and their products. Certain inflammatory cytokines produced during periodontal inflammation increase the production of acute phase proteins like high‑sensitivity C‑reactive protein (hs‑CRP) and can depress erythropoietin production leading to the development of anemia.Aim:The aim of this study is to investigate the efficacy of nonsurgical periodontal therapy on red blood cell (RBC) parameters and hs-CRP in chronic periodontitis patients with anemia.Materials and Methods:This is a longitudinal, interventional study with 6-month follow-up. A total of 30 subjects with anemia and chronic periodontitis with age group of 33-55 years were selected by screening hemoglobin (Hb) levels and examining periodontal findings. The clinical parameters plaque index (PI), gingival index (GI), probing pocket depth (PPD) and clinical attachment level (CAL) were recorded at baseline. Laboratory blood investigations were performed to evaluate RBC count, Hb, packed cell volume (PCV), erythrocyte sedimentation rate (ESR) and red cell indices, hs-CRP at baseline. Nonsurgical periodontal therapy was performed for all patients. Patients were recalled after 6 months. The clinical and hematological parameters were re-evaluated to analyze the changes after nonsurgical periodontal therapy.Results:The results showed that there was a significant increase in Hb levels, RBC count and PCV from baseline to 6 months after nonsurgical periodontal therapy. There is significant decrease in levels of ESR and hs-CRP levels after nonsurgical periodontal therapy indicating resolution of periodontal inflammation. There is a significant decrease in PPD, scores of PI and GI and significant increase in CAL gain. Minimal changes in mean corpuscular volume, mean corpuscular hemoglobin (MCH) and MCH concentration indicated that the lower values of red cell parameters are not due to any vitamin and mineral deficiencies, but secondary to the chronic inflammatory changes associated with chronic periodontal disease.Conclusion:The present study strengthens the hypothesis that chronic periodontitis may lead to anemia and provides evidence that nonsurgical periodontal therapy can improve the anemic status and reduce levels of hs-CRP in patients with chronic periodontitis.

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“…Studies have showed that periodontitis patients with CVD or hypertension had significantly higher serum sensitivity CRP concentrations than patients without periodontitis [48]. Periodontal diseases are associated with changes in serum components that are consistent with the increased circulation of IL-6 and elevated levels of high sensitivity CRP [49]. Recently, clinical trials have shown a significant reduction of CPR levels and other inflammatory markers in serum after periodontal therapy [50].…”

Section: Effect Of Periodontal Intervention On C-reactive Proteinmentioning

confidence: 91%

Is a Potential Therapeutic Strategy of Periodontal Intervention on Cardiovascular Disease, Yes or No?

Chen¹,

Zhang²,

Xu³

et al. 2017

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Aims: Cardiovascular disease (CVD) and periodontitis are both chronic inflammatory disorders which are highly prevalent in populations. Bacteria involved in the periodontal disease have been found to be cardiovascular risk markers. Periodontal pathogens may contribute to the atheroma pathogenesis. Severe periodontitis is correlated with the prevalence of bacteraemia, and poor periodontal status is an important risk factor for CVD. However, the association is unclear. If the association is causal, the periodontal therapy will lead to an attenuation of the effects on CVD. The study aimed to study if the periodontal intervention therapy presented therapeutic effects on CVD. Methods: English language literature on periodontal intervention therapy on CVD is causal or not. The literature revealed 62 papers associated with this study to investigate the relationship between periodontitis and CVD. Results: The literature supported the idea that periodontal infections had been associated with CVD. Certain periodontal therapy is associated with bacteraemia, and the prevalence of bacteraemia may arise from periodontal therapy and poor oral hygiene practices. Periodontal therapy not only presented therapeutic effects by reducing cytokine activity and C-response protein (CRP), but also caused bacteraemia transitorily. Effective antibiotic prophylaxis pre-or post-periodontal therapy presented some beneficial effects on bacteraemia or CVD. Conclusion: Severe periodontitis causes systemic inflammation and endothelial dysfunction, and goes beyond the oral cavity. Periodontal intervention would contribute to the prevention of atherosclerosis, and antibiotic prophylaxis would be helpful to decrease bacteraemia and reduce the onset of CVD.

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Evaluation of the C-reactive protein serum levels in periodontitis patients with or without atherosclerosis

Abstract: Within the limits of this study it was concluded that periodontitis may add to the inflammatory burden of the individual and may result in increased risk of atherosclerosis based on serum C-reactive protein concentrations.

Cited by 22 publications

References 20 publications

Evaluation of serum c-reactive protein levels in subjects with aggressive and chronic periodontitis in comparison with healthy controls: A clinico-biochemical study

Evaluation of serum c-reactive protein levels in subjects with aggressive and chronic periodontitis in comparison with healthy controls: A clinico-biochemical study

Evaluation of nonsurgical periodontal therapy in chronic periodontitis patients with anemia by estimating hematological parameters and high-sensitivity C-reactive protein levels

Is a Potential Therapeutic Strategy of Periodontal Intervention on Cardiovascular Disease, Yes or No?

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