Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis

Abstract

Brown rice is a staple dietary constituent in Asia, whereas rice consumed in the Western world is generally white, obtained from brown rice by removal of the bran. We tested the hypothesis that rice bran interferes with development of tumours in TAg, TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) or Apc Min mice, genetic models of mammary, prostate and intestinal carcinogenesis, respectively. Mice received rice bran (30%) in AIN-93G diet throughout their post-weaning lifespan. In TAg and TRAMP mice, rice bran did not affect carcinoma development. In TRAMP or wild-type C57Bl6/J mice, dietary rice bran increased kidney weight by 18 and 20%, respectively. Consumption of rice bran reduced numbers of intestinal adenomas in Apc Min mice by 51% (Po0.01), compared to mice on control diet. In parallel, dietary rice bran decreased intestinal haemorrhage in these mice, as reflected by increased haematocrit. At 10% in the diet, rice bran did not significantly retard Apc Min adenoma development. Likewise, low-fibre rice bran (30% in the diet) did not affect intestinal carcinogenesis, suggesting that the fibrous constituents of the bran mediate chemopreventive efficacy. The results suggest that rice bran might be beneficially evaluated as a putative chemopreventive intervention in humans with intestinal polyps.

By-products of Rice Processing: An Overview of Health Benefits and Applications

“…Some of these phenolic compounds have been reported to inhibit the growth of human breast and colon cancer cells [85]. There is no evidence to indicate that rice husk is carcinogenic or mutagenic.…”

“…Rice bran inhibits the growth of human colon cancer cells [85], and rice bran consumption reduces the number of intestinal adenomas in APC Min mice, an animal model of human familial adenomatous polyposis (FAP) [86]. Finally, DMH-and AOM-induced preneoplastic lesions are inhibited by rice bran-derived sphingolipids in the colons of rats [87,88].…”

Effects of brown rice, rice bran, and polished rice on colon carcinogenesis in rats

“…To our knowledge, few studies have examined the effect of rice on colorectal carcinogenesis, although several have found that individual components of rice are protective. For example, it was found that water-soluble rice bran hemicellulose prevents 1,2-dimethylhydrazine (DMH)-induced colonic tumors in rats (Aoe et al, 1993); rice germ prevents azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF, a preneoplastic lesion of colon cancer) and tumors in rats (Kawabata et al, 1999); extracts of brown rice and rice bran inhibit the growth of human colon cancer cells (Hudson et al, 2000); consumption of rice bran reduces the number of intestinal adenomas in APC Min mice, an animal model of human familial adenomatous polyposis (FAP) (Verschoyle et al, 2007); and rice bran-derived sphingolipids inhibit DMH-and AOM-induced preneoplastic lesions in the colon of rats (Inamine et al, 2005;Sunagawa et al, 2009).…”

“…Rice (Oryza sativa) is a staple food of over half the world's population especially in Asia, where the incidence of colorectal cancer is markedly lower than that in the Western world (Hudson, Dinh, Kokubun, Simmonds, & Gescher, 2000;Verschoyle et al, 2007). Since the consumption of rice is a major dietary difference between Asian and Western countries, it is important to determine whether rice can affect colorectal cancer risk.…”

Peran Fisiologis Sari Kedelai Hitam Diperkaya Mikroenkapsulan Minyak Sawit Mentah Pada Penderita Diabetes Melitus Tipe-2

“…Serat kedelai mengandung pektin, galaktomanan, dan arabinogalaktan yang memiliki viskositas yang tinggi. Komponen serat ini dapat memperlambat laju pencernaan dan penyerapan glukosa (Verschoyle et al, 2007). Pengaruh dari serat kedelai menjadi penyebab penurunan laju pencernaan yang berakibat pada perlambatan penyerapan glukosa dengan membatasi laju difusi intraluminal glukosa dengan penyerapan permukaan.…”