Evaluation of the changes in serum iron levels in pre-eclampsia

Gupta, Shalini; Nanda, Smiti; Singh, Uma; Bansal, Sadhna; Lal, Harbans

doi:10.1007/bf02867964

Cited by 6 publications

(9 citation statements)

References 6 publications

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“…Suc is mostly cleaved by Suc synthase (EC 2.4.1.13) (12,23). The cleavage products are metabolized through glycolysis, the enzyme activities of which are present in both cytosol and plastid (3,9,14). Resynthesis of Fru-6-P from triose phosphate is possible by plastidic fructose-1,6-bisphosphatase (EC 3.1.3.11) or cytosolic pyrophosphatedependent fructose-6-phosphate-1-phosphotransferase (EC 2.7.1.90) (9).…”

Section: Defining the Metabolic Networkmentioning

confidence: 99%

“…Resynthesis of Fru-6-P from triose phosphate is possible by plastidic fructose-1,6-bisphosphatase (EC 3.1.3.11) or cytosolic pyrophosphatedependent fructose-6-phosphate-1-phosphotransferase (EC 2.7.1.90) (9). Exchange of intermediates between cytosol and plastids can occur by the transport of Glc-6-P, triose phosphate, PEP, pentose phosphate, and pyruvate (3,9,14,46).…”

Section: Defining the Metabolic Networkmentioning

confidence: 99%

“…For B. napus embryos, it was concluded that hexose is mainly imported into the plastids in the form of Glc-6-P, whereas Glc-1-P was not used by isolated plastids (9). Import of the starch precursor ADP-Glc into the plastids can be excluded because of the subcellular localization of ADP-Glc pyrophosphorylase (EC 2.7.7.27) in B. napus embryos (5,14,47).…”

Section: Defining the Metabolic Networkmentioning

confidence: 99%

“…Incomplete Cytosolic OPPP-In developing B. napus seeds, glucose-6-phosphate dehydrogenase (EC 1.1.1.49) activity is found in plastids and the cytosol (9,14). The regeneration of Fru-6-P from pentose phosphate involves ribose-5-phosphate isomerase (EC 5.1.3.1), ribulose-5-phosphate epimerase (EC 5.3.1.6), TK, and TA.…”

Section: Defining the Metabolic Networkmentioning

confidence: 99%

“…For example, 14 CO 2 release from 14 C Glc by castor bean endosperm (73) suggested that 50 -70% of NADPH needed for fatty acid synthesis can be provided by OPPP. However, that study applied a simplified flux model without consideration of resynthesis of Fru-6-P from triose phosphate.…”

Section: Quantification Of the Split Of Carbon Flux Between Glycolysimentioning

confidence: 99%

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A Flux Model of Glycolysis and the Oxidative Pentosephosphate Pathway in Developing Brassica napus Embryos

Schwender

Ohlrogge

Shachar‐Hill

2003

Journal of Biological Chemistry

242

252

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Computer simulation of the steady state distribution of isotopomers in intermediates of the glycolysis/OPPP network was used to fit metabolic flux parameters to the experimental data. The observed distribution of label in cytosolic and plastidic metabolites indicated that key intermediates of glycolysis and OPPP have similar labeling in these two compartments, suggesting rapid exchange of metabolites between these compartments compared with net fluxes into end products. Cycling between hexose phosphate and triose phosphate and reversible transketolase velocity were similar to net glycolytic flux, whereas reversible transaldolase velocity was minimal. Flux parameters were overdetermined by analyzing labeling in different metabolites and by using data from different labeling experiments, which increased the reliability of the findings. Net flux of glucose through the OPPP accounts for close to 10% of the total hexose influx into the embryo. Therefore, the reductant produced by the OPPP accounts for at most 44% of the NADPH and 22% of total reductant needed for fatty acid synthesis.Brassica napus (rapeseed, canola) is one of the world's major oilseed crops and is also a well studied model for oilseed metabolism (1-21). The main storage compounds in seeds of B. napus are oil (triacylglycerols) and storage proteins, which are derived from sugars and amino acids taken up from the surrounding endosperm liquid (11,12,22,23). Because of its high oil content and ease of genetic transformation, B. napus has also been a target for metabolic engineering of oil metabolism. However, some attempts to engineer plant oils have had limited success (for a review, see Ref. 24). In order to make advances in improving oil yield and quality, a more detailed understanding of metabolism during seed development is needed. In particular, a number of fundamental metabolic issues remain unresolved. These include the source(s) of reductant and ATP for fatty acid synthesis; the degree to which cytosolic, plastidial, and mitochondrial metabolic fluxes are integrated; and the chief metabolic and transport route(s) by which carbon flows from maternal sources to seed storage products.

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Section: Defining the Metabolic Networkmentioning

confidence: 99%

Section: Defining the Metabolic Networkmentioning

confidence: 99%

Section: Defining the Metabolic Networkmentioning

confidence: 99%

Section: Defining the Metabolic Networkmentioning

confidence: 99%

Section: Quantification Of the Split Of Carbon Flux Between Glycolysimentioning

confidence: 99%

See 3 more Smart Citations

A Flux Model of Glycolysis and the Oxidative Pentosephosphate Pathway in Developing Brassica napus Embryos

Schwender

Ohlrogge

Shachar‐Hill

2003

Journal of Biological Chemistry

242

252

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Iron status parameters in preeclamptic women

Siddiqui

Jaleel

Kadri

et al. 2010

Arch Gynecol Obstet

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Increased serum iron levels in pregnant women with preeclampsia: a meta-analysis of observational studies

Liu

Chen

et al. 2018

Journal of Obstetrics and Gynaecology

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Our study aimed to investigate whether the serum iron levels in patients with preeclampsia were higher than in healthy pregnant women and to evaluate potential heterogeneities. We searched Pubmed, Embase, Web of Science and Medline databases for studies before September 2016. The standardised mean difference (SMD) and 95% confidence interval (CI) were used to combine results across the studies, in addition to the random-effect model. A total of 10 studies involving 363 patients with preeclampsia and 370 healthy controls were eligible through the inclusion criteria. In comparison with healthy pregnant women, the serum iron levels are higher in the patients with preeclampsia [summary SMD = 0.28, 95% CI = 0.11-0.44], and this association was also significant in the case-control studies. The serum iron levels were higher in the pregnant women with preeclampsia than in the healthy controls in both the Asian and European populations. Our study provides significant evidence of higher serum iron levels in the patients with preeclampsia than in healthy pregnant women. Impact Statement What is already known on this subject? Serum iron levels have inconsistent associations with a risk of preeclampsia in pregnant women. What the results of this study add? Compared with healthy pregnant women, serum iron levels are higher in patients with preeclampsia. What the implications are of these findings for clinical practice and/or further research? Further studies across large numbers of cases and increased patient populations are necessary to confirm our findings.

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Evaluation of the changes in serum iron levels in pre-eclampsia

Cited by 6 publications

References 6 publications

A Flux Model of Glycolysis and the Oxidative Pentosephosphate Pathway in Developing Brassica napus Embryos

A Flux Model of Glycolysis and the Oxidative Pentosephosphate Pathway in Developing Brassica napus Embryos

Iron status parameters in preeclamptic women

Increased serum iron levels in pregnant women with preeclampsia: a meta-analysis of observational studies

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