Evaluation of the chorioretinal thickness changes in <scp>A</scp>lzheimer's disease using spectral‐domain optical coherence tomography

Bayhan, Hasan Alı; Bayhan, Seray Aslan; Çelikbilek, Asuman; Tanık, Nermin; Gürdal, Canan

doi:10.1111/ceo.12386

Cited by 118 publications

(142 citation statements)

References 37 publications

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“…Figure 3 depicts these changes in choroidal thickness. These findings have been corroborated by further studies [62,63]. One study also included patients with MCI, and observed reduced CT in this group, although no statistically significant differences between the MCI and AD patient groups were found [63].…”

Section: Pathological Changes In the Retina And Optic Nervesupporting

confidence: 64%

“…More recent OCT studies have reported also macular changes in the ganglion cell complex (GCC), comprising the ganglion cell layer (GCL) and inner plexiform layer (IPL). Also, choroidal thickness [60] has been shown to be reduced in patients with AD, as measured by EDI-OCT Spectralis Heidelberg [61][62][63].…”

Section: Pathological Changes In the Retina And Optic Nervementioning

confidence: 99%

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Alzheimer’s disease: A review of its visual system neuropathology. Optical coherence tomography—a potential role as a study tool in vivo

Cunha

Moura-Coelho

Proença

et al. 2016

Graefes Arch Clin Exp Ophthalmol

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Alzheimer's disease (AD) is a prevalent, long-term progressive degenerative disorder with great social impact. It is currently thought that, in addition to neurodegeneration, vascular changes also play a role in the pathophysiology of the disease. Visual symptoms are frequent and are an early clinical manifestation; a number of psychophysiologic changes occur in visual function, including visual field defects, abnormal contrast sensitivity, abnormalities in color vision, depth perception deficits, and motion detection abnormalities. These visual changes were initially believed to be solely due to neurodegeneration in the posterior visual pathway. However, evidence from pathology studies in both animal models of AD and humans has demonstrated that neurodegeneration also takes place in the anterior visual pathway, with involvement of the retinal ganglion cells' (RGCs) dendrites, somata, and axons in the optic nerve. These studies additionally showed that patients with AD have changes in retinal and choroidal microvasculature. Pathology findings have been corroborated in in-vivo assessment of the retina and optic nerve head (ONH), as well as the retinal and choroidal vasculature. Optical coherence tomography (OCT) in particular has shown great utility in the assessment of these changes, and it may become a useful tool for early detection and monitoring disease progression in AD. The authors make a review of the current understanding of retinal and choroidal pathological changes in patients with AD, with particular focus on invivo evidence of retinal and choroidal neurodegenerative and microvascular changes using OCT technology.

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Section: Pathological Changes In the Retina And Optic Nervesupporting

confidence: 64%

Section: Pathological Changes In the Retina And Optic Nervementioning

confidence: 99%

Alzheimer’s disease: A review of its visual system neuropathology. Optical coherence tomography—a potential role as a study tool in vivo

Cunha

Moura-Coelho

Proença

et al. 2016

Graefes Arch Clin Exp Ophthalmol

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“…In some studies performed on dementia-group diseases causing cognitive impairment, a significant correlation was found between the MMSE score and RNFL thickness (30,31) . In addition, in a study by Bayhan et al, a significant correlation was (32) found between the MMSE score and the mean GC-IPL thickness. Conversely, in another study, no correlation was found between the MMSE score and RNFL thickness (33) .…”

Section: Discussionmentioning

confidence: 86%

Cognitive performance of primary open-angle glaucoma and normal-tension glaucoma patients

Bulut¹,

Yaman²,

Erol³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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RESUMO Objetivos: Avaliar as diferenças de desempenho cognitivo entre pacientes com glau coma primário de ângulo aberto (POAG), glaucoma de pressão normal (NTG) e controle de indivíduos saudáveis (C).Métodos: Um total de 60 pessoas (20 POAG, 20 NTG e 20 85,2 ± 14,7, 76,8 ± 10,3 e 91,4 ± 7,7 µm nos grupos POAG, NTG e controles, respectivamente (p<0,001). As espessuras médias da GCIPL observadas foram 77.5 ± 9.7 μm no grupo POAG, 73,4 ± 7,8 ABSTRACTPurpose: To assess cognitive performance differences among primary open-angle glaucoma (POAG) patients, normal-tension glaucoma (NTG) patients, and healthy control (C) subjects. Methods: A total of 60 participants (20 POAG, 20 NTG, and 20 C subjects) were included in this study. A detailed ophthalmologic examination was performed on all participants. A spectral domain-optical coherence tomography (SD-OCT) system was used to measure the ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL) thicknesses. To assess the cognitive performance of all participants, detailed neurological examinations, including the mini-mental state examination (MMSE), were performed by the same neurologist. Results: There were no significant differences among the groups in terms of age (p=0.348) or gender (p=0.935). The mean RNFL thicknesses were significantly diffe rent among the groups (85.2 ± 14.7, 76.8 ± 10.3, and 91.4 ± 7.7 µm in the POAG, NTG, and C subjects, respectively; p<0.001). The mean GC-IPL thicknesses were 77.5 ± 9.7 µm in the POAG group, 73.4 ± 7.8 µm in the NTG group, and 78.8 ± 3.8 µm in the C group. Differences among the groups were not statistically significant (p=0.085). MMSE scores were 26.1 ± 1.4, 25.7 ± 2.3, and 28.8 ± 0.9 in the POAG, NTG, and C groups, respectively. There were significant differences among the three groups (p<0.001). Specifically, there were significant differences between the NTG and C groups (p<0.001), and between the POAG and C groups (p=0.001). There was no significant difference between the POAG and NTG groups (p=0.595). Conclusions: There appear to be similar risk factors in glaucoma and neurodegenerative disorders that cause deterioration in cognitive performance. Comparing the low MMSE scores of the POAG and NTG patients with the scores of healthy C participants supports our hypothesis. Consequently, it is recommended that a neurologist should also examine glaucoma patients.

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“…Historically, these visual and circadian rhythm disturbances were attributed to pathology in the brain yet are now being revisited and explored as a potential direct outcome of ocular pathologies. Among ocular tissues, studies have shown that the retina is massively impacted by AD [466, 472, 474–479, 482, 484, 486, 487, 490–507]. The retina of MCI subjects and AD patients displays a host of abnormalities including nerve fiber layer (NFL) thinning, optic nerve and retinal ganglion cell (RGC) degeneration, macular volume changes, retinal angiopathy involving reduced blood flow and vascular structural alterations, astrogliosis, and abnormal electroretinogram patterns [472].…”

Section: Contribution and Role Of Retinal Imagingmentioning

confidence: 99%

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

Hampel

Toschi

Babiloni

et al. 2018

JAD

132

113

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The Precision Neurology development process implements systems theory with system biology and neurophysiology in a parallel, bidirectional research path: a combined hypothesis-driven investigation of systems dysfunction within distinct molecular, cellular and large-scale neural network systems in both animal models as well as through tests for the usefulness of these candidate dynamic systems biomarkers in different diseases and subgroups at different stages of pathophysiological progression. This translational research path is paralleled by an “omics”-based, hypothesis-free, exploratory research pathway, which will collect multimodal data from progressing asymptomatic, preclinical and clinical neurodegenerative disease (ND) populations, within the wide continuous biological and clinical spectrum of ND, applying high-throughput and high-content technologies combined with powerful computational and statistical modeling tools, aimed at identifying novel dysfunctional systems and predictive marker signatures associated with ND. The goals are to identify common biological denominators or differentiating classifiers across the continuum of ND during detectable stages of pathophysiological progression, characterize systems-based intermediate endophenotypes, validate multi-modal novel diagnostic systems biomarkers, and advance clinical intervention trial designs by utilizing systems-based intermediate endophenotypes and candidate surrogate markers. Achieving these goals is key to the ultimate development of early and effective individualized treatment of ND, such as Alzheimer’s disease (AD). The Alzheimer Precision Medicine Initiative (APMI) and cohort program (APMI-CP), as well as the Paris based core of the Sorbonne University Clinical Research Group “Alzheimer Precision Medicine” (GRC-APM) were recently launched to facilitate the passageway from conventional clinical diagnostic and drug development towards breakthrough innovation based on the investigation of the comprehensive biological nature of aging individuals. The APMI movement is gaining momentum to systematically apply both systems neurophysiology and systems biology in exploratory translational neuroscience research on ND.

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Evaluation of the chorioretinal thickness changes in Alzheimer's disease using spectral‐domain optical coherence tomography

Abstract: Patients with AD had chorioretinal structural alterations. Retinal structural alterations were seen only in the inner layers. The reduction in mGCC thickness parameters were related to the severity of cognitive impairment in AD.

Cited by 118 publications

References 37 publications

Alzheimer’s disease: A review of its visual system neuropathology. Optical coherence tomography—a potential role as a study tool in vivo

Alzheimer’s disease: A review of its visual system neuropathology. Optical coherence tomography—a potential role as a study tool in vivo

Cognitive performance of primary open-angle glaucoma and normal-tension glaucoma patients

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

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