Evaluation of the clinical characteristics and prognostic factors of gastrointestinal non-Hodgkin lymphoma based on anatomical sites and histological subtype

Factors associated with unresponsiveness to treatment in patients with non-Hodgkin lymphoma: 10 years of experience from a single center

“…Our results showed that female sex, low ECOG-PS score, presence of frailty and high lymphocyte count (at baseline), and the presence of extranodal involvement, mantle cell lymphoma, thrombocytopenia and cardiac complications (during treatment) were poor prognostic factors independently associated with unresponsiveness to treatment. In one study, advanced disease was shown to be a risk factor for recurrent or resistant disease in patients with gastrointestinal NHL (GISNHL) [14]. Provencio et al reported that C-MYC mRNA positivity in pretreatment samples was a significant predictor of poor progression-free survival and absence of complete response to first-line treatment [15].…”

“…New studies and prognostic markers are needed to identify high-risk patients who are unlikely to respond to treatment [11]. While there are plenty of studies investigating prognostic factors associated with mortality and survival in NHL patients, the number of studies investigating prognostic factors in the context of treatment response is rather low [14,15]. Moreover, existing studies have investigated a limited number of factors [14,15].…”

“…While there are plenty of studies investigating prognostic factors associated with mortality and survival in NHL patients, the number of studies investigating prognostic factors in the context of treatment response is rather low [14,15]. Moreover, existing studies have investigated a limited number of factors [14,15]. Therefore, we aimed to investigate factors related to treatment response in NHL patients receiving chemo(radio) therapy and, as a secondary aim, to identify factors associated with mortality.…”