Evaluation of the commonest site, demographic profile and most effective therapy in scabies

Das, Sudip; Chatterjee, Tapas; Banerji, G; Biswas, Indranil

doi:10.4103/0019-5154.27981

Cited by 15 publications

(39 citation statements)

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“…Some of the previous studies have reported similar results,[610–12] but the interesting finding was the lesser decrease in pruritus score with ivermectin as compared to permethrin. None of the previous studies have reported the superior efficacy of ivermectin.…”

Section: Discussionsupporting

confidence: 61%

Comparison of safety, efficacy, and cost effectiveness of benzyl benzoate, permethrin, and ivermectin in patients of scabies

et al. 2009

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Objective:To compare three treatment modalities in scabies for safety, efficacy, and economy in a local population of Nagpur.Materials and Methods:This was a prospective, randomized, comparative clinical trial conducted in 103 participants, randomly allocated to three groups. First group received benzyl benzoate (BB) 25% lotion, second group received permethrin 5% cream, whereas third group received tablet ivermectin 200 μg/kg as a single dose. The participants were recalled after one week for follow-up evaluation. If there were no signs of cure, the same intervention was repeated. The participants were followed up for two weeks for cure rate, adverse drug reaction (ADR) monitoring, and postintervention observation. The follow-up was stopped after two weeks.Statistics:Fischer's exact test using Graph pad Instat v 3.05.Results:Ivermectin showed 100% cure rate after two weeks of treatment. Permethrin decreased pruritus by 76% at the end of one week and had significantly better cure rate than ivermectin. At the end of two weeks treatment, this finding was reversed, that is, cure rate in ivermectin group was 100%. For cost-effectiveness analysis, treatment regimens were formulated hypothetically for comparison from Markov population tree for decision analysis. It was found that BB and ivermectin each consecutively for two weeks were most cost effective regimens giving complete cure in four weeks, while ivermectin was the fastest regimen giving the same results in two weeks.Conclusion:Benzyl benzoate as first line intervention and ivermectin in the remaining gave best cost-effective results in the study patients of scabies.

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Section: Discussionsupporting

confidence: 61%

Comparison of safety, efficacy, and cost effectiveness of benzyl benzoate, permethrin, and ivermectin in patients of scabies

et al. 2009

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“…Out of 30 participants, 21(70%) were male and 9 (30%) were female patients. This study suggested male preponderance (Table-2) which is in conformity with the findings of Ali S M et al 18 Noor Ursani M, Baloch G H, 19 Khan I, Yasmin R, 20 Sharquie KE, 21 Das S, and Chatterjee T et al 22 Out of 30 patients, 26 (86.66%) patients were non vegetarian and 4(13.33%) patients were vegetarian. Association of dietary habit with scabies has not yet been studied comprehensively, and hence a particular type of diet does not seem to have any casual relationship with scabies.…”

Section: Discussionsupporting

confidence: 90%

“…This finding is in accordance to description of Unani description as observed by Das S, Chatterjee T et al . 22 In this study, 25 (83.33%) patients were belonged to urban area and 5 (16.66%) were from the rural area. It inferred that Jarb is directly related to the overcrowded areas with least sanitation care and low socio economic strata.…”

Section: Discussionmentioning

confidence: 61%

Therapeutic Evaluation of Zimad-E-Jarb in Jarb (Scabies): A Single Blind Randomized Controlled Study

Haque¹,

Ahmad²,

Khalid³

et al. 2016

J Biol Sci Opin

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Scabies is a contagious skin disease, caused by Sarcoptes scabiei which affects around 300 million populations every year globally affecting mostly the children; but can occur in any age group and the incidence is similar in both sexes. The present clinical trial was designed to evaluate the efficacy of Zimad-e-Jarb in the management of Jarb on scientific parameters. It was a single blind randomized controlled study and was conducted on 30 patients of Jarb at National Institute of Unani Medicine, Bangalore. Participants fulfilling the inclusion criteria were included in the study, and were randomly allocated into Group A (n=20) and group B (n=10). Zimad-e-Jarb and 5% Permethrin lotion was given to the Group A and group B for 7 days and one day respectively as locally. Assessments were carried out on subjective & objective parameters weekly three times using arbitrary scale and VAS (pruritus) respectively. The result was analyzed statistically and both the drugs had significant effect on objective parameters (p<0.01). However control drug has shown more pronounced effect than test drug and no side effect was observed during and after the study. The study revealed that Zimad-e-Jarb is effective in Jarb in terms of itching, erythema, papules and number of lesions without any side effect. Therefore, it may be concluded that the test drug is safe & effective in management of Jarb.

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“…We contacted the authors of six studies to obtain missing data or to clarify inconsistent information ( Das 2006 ; Mushtaq 2010 ; Saqib 2012 ; Rohatgi 2013 ; Wankhade 2013 ; Manjhi 2014 ); the authors of two studies replied ( Saqib 2012 ; Rohatgi 2013 ). Details are reported in the respective Characteristics of included studies tables.…”

Section: Resultsmentioning

confidence: 99%

“… Abdel‐Raheem 2016 investigated topical permethrin and systemic ivermectin (plus two groups treated with sulfur ointment or benzyl benzoate cream not included in this review). Das 2006 also examined the effect of gamma benzene hexachloride 1% and included a placebo group. Manjhi 2014 investigated topical permethrin and systemic ivermectin (plus two groups treated with gamma benzene hexachloride 1% lotion or benzyl benzoate 20% lotion not included in this review).…”

Section: Resultsmentioning

confidence: 99%

Ivermectin and permethrin for treating scabies

Rosumeck

Nast

Dressler

2018

Cochrane Database of Systematic Reviews

104

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Evaluation of the commonest site, demographic profile and most effective therapy in scabies

Cited by 15 publications

References 0 publications

Comparison of safety, efficacy, and cost effectiveness of benzyl benzoate, permethrin, and ivermectin in patients of scabies

Comparison of safety, efficacy, and cost effectiveness of benzyl benzoate, permethrin, and ivermectin in patients of scabies

Therapeutic Evaluation of Zimad-E-Jarb in Jarb (Scabies): A Single Blind Randomized Controlled Study

Ivermectin and permethrin for treating scabies

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