Evaluation of the composition of the microbiota of the urethra in men with sexually transmitted  infections

Rakhmatulina, M R; Boldyreva, M N; Lipova, E V; Chekmarev, Alexey; Галкина, И. С.

doi:10.18565/urology.2019.6.31-37

Cited by 3 publications

(1 citation statement)

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“…On the other hand, the relative number of Anaerococcus spp. were significantly higher in men infected with N. gonorrhoeae than in healthy men [ 146 ].…”

Section: Interactions Between N Gonorrhoeae and Th...mentioning

confidence: 99%

Molecular Regulatory Mechanisms Drive Emergent Pathogenetic Properties of Neisseria gonorrhoeae

2022

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Neisseria gonorrhoeae is the causative agent of the sexually transmitted infection (STI) gonorrhea, with an estimated 87 million annual cases worldwide. N. gonorrhoeae predominantly colonizes the male and female genital tract (FGT). In the FGT, N. gonorrhoeae confronts fluctuating levels of nutrients and oxidative and non-oxidative antimicrobial defenses of the immune system, as well as the resident microbiome. One mechanism utilized by N. gonorrhoeae to adapt to this dynamic FGT niche is to modulate gene expression primarily through DNA-binding transcriptional regulators. Here, we describe the major N. gonorrhoeae transcriptional regulators, genes under their control, and how these regulatory processes lead to pathogenic properties of N. gonorrhoeae during natural infection. We also discuss the current knowledge of the structure, function, and diversity of the FGT microbiome and its influence on gonococcal survival and transcriptional responses orchestrated by its DNA-binding regulators. We conclude with recent multi-omics data and modeling tools and their application to FGT microbiome dynamics. Understanding the strategies utilized by N. gonorrhoeae to regulate gene expression and their impact on the emergent characteristics of this pathogen during infection has the potential to identify new effective strategies to both treat and prevent gonorrhea.

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“…On the other hand, the relative number of Anaerococcus spp. were significantly higher in men infected with N. gonorrhoeae than in healthy men [ 146 ].…”

Section: Interactions Between N Gonorrhoeae and Th...mentioning

confidence: 99%

Molecular Regulatory Mechanisms Drive Emergent Pathogenetic Properties of Neisseria gonorrhoeae

2022

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PCR “Checkup” in Male in the Sexually Transmitted Infections. Trend Watching

Почерников¹,

Sapozhkova²

2022

Laboratornaya I Klinicheskaya Meditsina. Farmatsiya

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Most sexually transmitted infections (STIs) do not cause significant problems in the carrier, as a result the infection is transmitted easily to a sexual partner and may remain unrecognized with serious consequences for male reproductive health. Currently, the rapidest and most accurate method of STIs diagnosis is a molecular genetic analyses (MGA) for detection of DNA pathogens. The results of MGA do not depend on the cultural properties and morphological characteristics of the microorganism. Non-cultural methods based on a multiplex polymerase chain reaction in real time (PCR-RT) are becoming as a trend in modern laboratory medicine for identifying genes associated with antibiotic resistance. his approach can reduce turnaround time (ТАТ) for the male health benefit in time.

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Diagnostic significance of Lactobacillus spp. identification in ejaculate

Почерников

Postovoytenko

Гетьман

et al. 2020

BRSMU

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Popularization of the real-time polymerase chain reaction method (RT-PCR), which is a trend of the recent years, allowed to significantly expand of the range of microorganisms that can be detected in the genitourinary tract of men. Moreover, the available picture of the microbiome's bacterial component structure became more detailed. Lactobacillus spp. remains one of the least studied groups of microorganisms. Treating patients with reproductive disorders, the authors have accumulated clinical experience demonstrating the possible relationship between presence of Lactobacillus spp. in the ejaculate and changes in the level of sex hormones and the key values registered with a spermogram. This study aimed to compare the levels of luteinizing hormone, follicle-stimulating hormone, testosterone, estradiol, prolactin, progesterone, and sex hormone binding globulin (SHBG) in blood serum and changes in spermogram values in 210 men with and without Lactobacillus spp. detected in their ejaculate. The treatment group included 105 men whose ejaculate had Lactobacillus spp. in the amount of (Lg) ≥ 103, as detected by RT-PCR. The control group included 105 men whose ejaculate did not have Lactobacillus spp. detected; the microbiome's bacterial component structure of their ejaculate was normal. Compared to the control group, treatment group had hormonal disorders registered more often: abnormal levels of three or more hormones (p = 0.04), hyperestradiolemia (p = 0.05), increased level of SHBG (p = 0.01). It was established that the presence of Lactobacillus spp. in the ejaculate of treatment group participants is associated with oligoastenoteratozoospermia (p < 0.01), decreased concentration of spermatozoa (p = 0.01), their decreased motility (p < 0.01) morphology abnormalities (p < 0.01). Thus, the presence of Lactobacillus spp. in the ejaculate can be interpreted as an additional marker of hormonal imbalance and fertility dysfunction in men.

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Evaluation of the composition of the microbiota of the urethra in men with sexually transmitted infections

Cited by 3 publications

References 0 publications

Molecular Regulatory Mechanisms Drive Emergent Pathogenetic Properties of Neisseria gonorrhoeae

Molecular Regulatory Mechanisms Drive Emergent Pathogenetic Properties of Neisseria gonorrhoeae

PCR “Checkup” in Male in the Sexually Transmitted Infections. Trend Watching

Diagnostic significance of Lactobacillus spp. identification in ejaculate

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