Evaluation of the Contribution of Platelets to Clot Strength by Thromboelastography in Rabbits: The Role of Tissue Factor and Cytochalasin D

Abstract

Rabbits may serve as a model of hemostasis that closely approximates human situations to mechanistically determine the etiology of coagulopathy. The contribution of platelet function to total clot strength is similar to that observed in humans.

Effect of fluid resuscitation with balanced solutions on platelets: In vitro simulation of 20% volume substitution

“…Moreover clot strength, as measured by clot amplitude, depends not only on platelets, but also on fibrinogen and factor XIII concentrations, although the relative contribution of platelets is approximately 80% [21]. Based on clot elasticity, platelet contribution is 87-94% [25]. Secondly, the quantity of von Willebrand factor may impact clot stability and resulting bleeding time [19], postoperative blood loss [26], however in the present study its concentration was not measured.…”

Effects of Microporous Polysaccharide Powder in a Model of Dilution on Viscoelastic Characteristics of Clot Formation - An In-Vitro Study

“…In brief, clot formation alteration is measured by the device and displayed in typical tracings as well as different parameters of time and clot firmness. We performed an extrinsically activated test (EXTEM) 27 which analyzes the coagulation process after activation by recombinant tissue factor. Following parameters were recorded: Coagulation Time (CT (s)) which describes time from start of the reaction until first clot formation.…”

Impact de l’âge maternel avancé sur les profils de coagulation thrombo-élastographique du péripatum: une étude observationnelle prospective exploratoire

“…The G is inclusive of both enzymatic and platelet contributions to overall clot strength. 21 The CL30 refers to the percentage of clot lysis at 30 min after MA. We also recorded dynamic properties of clot formation which represent the kinetic properties of thrombus formation.…”