Evaluation of the Corneal Topographic Characteristics of Keratoconus With Orbscan II in Patients With and Without Atopy

Kaya, Vedat; Karakaya, Muharrem; Utine, Canan Aslı; Albayrak, Sinan; Oge, Omer Faruk; Yılmaz, Ömer Faruk

doi:10.1097/ico.0b013e3180de1e04

Cited by 97 publications

(49 citation statements)

References 22 publications

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“…86,87 Several authors did not find a statistically significant difference between a group of control and keratoconic patients. 31,88 Yet, Kaya et al 85 showed that individuals with keratoconus and atopy had a steeper and thinner ectatic area than individuals with keratoconus but without atopy. However, it is possible that the itching induced by atopy, which leads to eye rubbing is the most significant contributor to KC.…”

Section: Atopymentioning

confidence: 99%

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The Epidemiology and Etiology of Keratoconus

Gordon‐Shaag¹,

Millodot²,

Shneor³

2012

International Journal of Keratoconus and Ectatic Corneal Diseases

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Keratoconus is a noninflammatory disorder characterized by ectasia of the central or inferior portion of the cornea. This review presents the scant epidemiological information known to date and the factors believed to cause the development of the disease. They are the genetic factors for which evidence come from family studies, twin studies and genetic loci. There appears to be multiple genes causing a keratoconus phenotype with variable penetration. However, the genetic predisposition might not be enough; environmental factors, such as eye rubbing, atopy and UV exposure, may have a role in generating the disease.

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Section: Atopymentioning

confidence: 99%

“…3,12,18,79,84,85 However, the effect of atopy is controversial. 86,87 Several authors did not find a statistically significant difference between a group of control and keratoconic patients.…”

Section: Atopymentioning

confidence: 99%

The Epidemiology and Etiology of Keratoconus

Gordon‐Shaag¹,

Millodot²,

Shneor³

2012

International Journal of Keratoconus and Ectatic Corneal Diseases

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“…16 Several reports have identified topographic parameters important in distinguishing keratoconic from normal corneal morphologic features; these include asymmetric bow-tie astigmatism, posterior corneal elevation, local areas of increased surface power, central corneal keratometric steepening, and inferior-superior dioptric asymmetry. 3,15,17 Keratoconus is largely regarded as a bilateral but asymmetric disease, affecting 1 eye earlier and more severely in most cases. Reports of inter-eye asymmetry between the corneal curvatures of keratoconus have noted differences of 3.50 to 4.00 diopters (D), 18,19 although the causes of this asymmetry have yet to be established.…”

mentioning

confidence: 99%

Computerized corneal tomography and associated features in a large New Zealand keratoconic population

Jordan

Zamri

Wheeldon

et al. 2011

Journal of Cataract and Refractive Surgery

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“…They affect several epithelia including the skin (atopic dermatitis, AD), the respiratory tract (asthma, allergic rhinitis) and the eye (allergic conjunctivitis). Atopic diseases, especially AD, have been associated with KC in a number of uncontrolled studies with conflicting data according to the type of patient recruitment [2,3,4,5,6,7] (table 1). …”

Section: Introductionmentioning

confidence: 99%

A Prospective Study of Filaggrin Null Mutations in Keratoconus Patients with or without Atopic Disorders

Droitcourt¹,

Touboul²,

Ged³

et al. 2011

Dermatology

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Background: Atopic dermatitis (AD) is significantly associated with keratoconus (KC). An inherited component for KC has been suggested. Filaggrin (FLG) mutations are a strong genetic risk factor for AD. Since filaggrin is also expressed in the corneal epithelium, we hypothesized a common aetiology for ichthyosis vulgaris (IV), AD and KC. Objectives: We examined the prevalence of AD and IV in a KC population. We also studied the expression of filaggrin in normal and KC cornea and analysed 2 prevalent loss-of-function FLG alleles (R501X and 2282del4) in a KC population. Finally we examined whether the population with KC and FLG mutations had specific clinical characteristics. Results: Of 89 KC patients, 38 had current or a history of AD and/or IV. Five patients were carriers of at least 1 FLG mutant allele and had a clinical diagnosis of AD and IV with a severer KC. Conclusion: The low frequency of FLG mutations is surprising since 42.7% of our KC population had AD associated or not with IV; the expected frequency would have been 12–15%, based on our previous studies. Further studies are required to look at other possible FLG mutations or other candidate genes.

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Evaluation of the Corneal Topographic Characteristics of Keratoconus With Orbscan II in Patients With and Without Atopy

Abstract: : This study shows that corneal topographic and pachymetric characteristics of keratoconus may be different in atopic eyes from those in nonatopic eyes. Atopic keratoconus patients could possibly be evaluated as a separate entity in keratoconus disease.

Cited by 97 publications

References 22 publications

The Epidemiology and Etiology of Keratoconus

The Epidemiology and Etiology of Keratoconus

Computerized corneal tomography and associated features in a large New Zealand keratoconic population

A Prospective Study of Filaggrin Null Mutations in Keratoconus Patients with or without Atopic Disorders

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