Evaluation of the coronary flow by the coronary clearance time in patients with cardiac syndrome X

Yıldırım, Erkan; Yuksel, Uygar Cagdas; Çelik, Murat; Buğan, Barış; Gungor, Mutlu; Gökoğlan, Yalçın; Köklü, Mustafa; Görmel, Suat; Yaşar, Salim; Barçın, Cem

doi:10.1177/0300060517743671

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…Furthermore, previous researches with scintigraphic myocardial perfusion imaging and nuclear magnetic resonance imaging demonstrated that subjects with microvascular angina had significantly reduced myocardial perfusion. Yildirim et al demonstrated that coronary clearance frame count (CCFC) in the three major coronary arteries (left anterior descending, circumflex, and right coronary arteries) was significantly delayed in subjects with microvascular angina compared with the control group. They suggested that CCFC may be a sign of microvascular dysfunction in patients with microvascular angina.…”

Section: Discussionmentioning

confidence: 99%

Right ventricular mechanics and exercise capacity in patients with microvascular angina: The impact of microvascular function

2019

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Objectives:We planned to assess the right ventricular mechanics in subjects with typical chest pain and angiographically normal coronary arteries (microvascular angina [MVA]) and to search for an association between right ventricular mechanics, coronary flow reserve, and exercise tolerance.Methods: Seventy-one patients with MVA (mean age of 48.5 ± 7.9 years, 63% female) and 30 healthy control subjects were recruited. Right ventricular mechanics were calculated utilizing speckle tracking imaging. The exercise capacity was assessed by metabolic equivalents (METs). Coronary flow reserve (CFR) was calculated as the ratio between hyperemic (in response to intravenous adenosine) diastolic peak flow velocity and the basal diastolic peak velocity. Results: Coronary flow reserve (a surrogate marker of microvascular dysfunction) was diminished in MVA patients compared with the control group (2.41 ± 0.35 vs 3.35 ± 0.5; P < .03). Patients with lower right ventricular global longitudinal strain (RVGLS) and right ventricular global longitudinal strain rate (RVGLSr) had a considerably lower CFR (P < .001) and a significantly lower MET (P < .001) than patients with normal RV mechanics. Right ventricular global longitudinal strain and RVGLSr were significantly correlated with both CFR and METs in subjects with MVA. Receiver operating characteristic (ROC) curve analysis demonstrated that RVGLS ≤ −14.5 was the best cutoff value for the prediction of impaired exercise tolerance in patients with MVA.

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Section: Discussionmentioning

confidence: 99%

Right ventricular mechanics and exercise capacity in patients with microvascular angina: The impact of microvascular function

2019

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A Cross-Sectional Study of Microcirculatory Transit Time as a Risk Stratification Method in Cardiac Syndrome X Conducted in a Tertiary Hospital at Hyderabad, Telangana

Parvathareddy¹,

Kolli²,

Srinivas³

et al. 2021

jebmh

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BACKGROUND Cardiac syndrome X (CSX) is not benign, and it needs long-term follow up and risk factor modification. In this study, we wanted to calculate microcirculatory transit time on coronary angiography in patients with cardiac syndrome X (CSX), compare microcirculatory transit time in patients with and without CSX and to see whether microcirculatory transit time can be proposed as a risk stratification method in CSX. METHODS Cross sectional study of 52 patients. The angiogram was taken at 15 frames per second. The left coronary artery was injected with 7 ml of contrast approximately. Microcirculatory transit time (MCTT) was obtained offline. The microcirculatory transit time in seconds is calculated as last frame count minus first frame count/15. Microcirculatory transit time was compared and analysed in both groups. RESULTS A total of 52 subjects were analysed. There were 26 cases in the angina group with a mean age of 49.96 years and 26 cases in the control group with a mean age of 50.32 years. Dyslipidemia, smoking and statin use were more common in the angina group, which was statistically significant (P < 0.05). The mean MCTT of the group with angina and positive treadmill test (TMT) was 6.76 seconds, whereas the negative TMT group was 6.39 seconds. The mean frame count was 58.1, and the mean MCTT was 3.8 seconds in the control group, whereas the mean frame count and mean MCTT were 98.1 and 6.5 seconds in the angina group, which was statistically significant (P < 0.001). CONCLUSIONS CSX patients had longer MCTT than patients without chest pain and normal coronary arteries. MCTT can be used to assess the risks of CSX. Long-term followup studies with a large sample size should be conducted. KEYWORDS Cardiac Syndrome X, Angina, Coronary Artery Disease, Microcirculation

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Evaluation of the coronary flow by the coronary clearance time in patients with cardiac syndrome X

Cited by 2 publications

References 27 publications

Right ventricular mechanics and exercise capacity in patients with microvascular angina: The impact of microvascular function

Right ventricular mechanics and exercise capacity in patients with microvascular angina: The impact of microvascular function

A Cross-Sectional Study of Microcirculatory Transit Time as a Risk Stratification Method in Cardiac Syndrome X Conducted in a Tertiary Hospital at Hyderabad, Telangana

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