Evaluation of the Craniofacial Morphology of Egyptian Adults Undergoing Orthodontic Treatment

Adel, Mohamed; Yamaguchi, Tetsutaro

doi:10.4172/2161-1122.1000379

Dentistry

2016

DOI: 10.4172/2161-1122.1000379

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Evaluation of the Craniofacial Morphology of Egyptian Adults Undergoing Orthodontic Treatment

Mohamed Adel¹,

Tetsutaro Yamaguchi²

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Cited by 2 publications

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“…It is essential to consider ethnicity before selecting variants for association studies, as there are differences in their biological structures and in the frequencies of haplotypes among different ethnic populations 16 . The Egyptian population, which has Caucasian origins, has a craniofacial form distinct from that of the East Asians, with a tendency toward skeletal Class malocclusion and a more convex profile 17 .…”

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Association of Growth Hormone Receptor Gene Variants with Mandibular Form in an Egyptian Population

:筆頭著者:責任著者

Yamaguchi

Tomita

et al. 2017

Showa Univ J Med Sci

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: A signi cant genetic component is involved in the development of the craniofacial form. Recently, the growth hormone receptor gene GHR variants rs6180 and rs6184 were associated with variations in mandibular form. To con rm these ndings we evaluated the relationship between these GHR variants and mandibular form in a cohort of Egyptian individuals with a normal skull form. The patients consisted of 191 unrelated Egyptian adults 92 males, 99 females ; 18-55 years . Allele frequencies of the rs6180 and rs6184 variants were determined from genomic DNA extracted from saliva using the Taqman genotyping assay. Lateral and posteroanterior cephalometric tracings were used to obtain 19 mandibular measurements. The association between the GHR variants and the mandibular measurements was examined using regression analysis. The frequency of the minor rs6184 variant was very low at 1.5 : therefore, association studies were not performed for this variant. The rs6180 variant was not associated with any of the measurements representing mandibular form in our study cohort. The frequency of the rs6184 variant was very low in our cohort of Egyptian subjects. We also found no association between the rs6180 variant and the measurements representing the mandibular form. By excluding the involvement of these GHR variants in in uencing mandibular form, our results may help to identify the actual variant s affecting the mandibular form in the Egyptian population.

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confidence: 99%

Association of Growth Hormone Receptor Gene Variants with Mandibular Form in an Egyptian Population

:筆頭著者:責任著者

Yamaguchi

Tomita

et al. 2017

Showa Univ J Med Sci

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A systematic diagnostic scheme for excessive gingival display “gummy smile”

El-Bokle

Ghany

2022

AJO-DO Clinical Companion

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Evaluation of the Craniofacial Morphology of Egyptian Adults Undergoing Orthodontic Treatment

Cited by 2 publications

References 25 publications

Association of Growth Hormone Receptor Gene Variants with Mandibular Form in an Egyptian Population

Association of Growth Hormone Receptor Gene Variants with Mandibular Form in an Egyptian Population

A systematic diagnostic scheme for excessive gingival display “gummy smile”

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