Evaluation of the cytotoxic and antitumour effects of the essential oil from <i>Mentha</i> x <i>villosa</i> and its main compound, rotundifolone

Amaral, Ricardo Guimarães; Fonseca, Cecília Santos; Silva, Tayane Kayne M; Andrade, Luciana Nalone; França, Maria E; Barbosa-Filho, José Maria; Sousa, Damião Pergentino de; Moraes, Manoel Odoríco de; Pessoa, Cláudia; Carvalho, Adriana Andrade; Thomazzi, Sara Maria

doi:10.1111/jphp.12409

Cited by 18 publications

(15 citation statements)

References 31 publications

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“…The low cytotoxicity of compounds isolated from Mentha spp. has also been demonstrated by Amaral et al (2015) who evaluated cytotoxicity of rotundifolone, a major constituent of the essential oil of Mentha x villosa against tumor cell lines HCT-116 and SF-295. The data obtained in the initial cytotoxicity assays indicate a potential therapeutic window for these compounds isolated to be used as antifungal agents.…”

Section: Discussionmentioning

confidence: 86%

Antifungal and cytotoxic activity of purified biocomponents as carvone, menthone, menthofuran and pulegone from Mentha spp.

Boni¹,

Feiria²,

Santana³

et al. 2016

Afr. J. Plant Sci.

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Medicinal plants are attractive sources in the search of bioactive compounds in the treatment of infectious diseases. Considering that the infectious agent often develops resistance to existing treatments rapidly, the searches for such compounds are a never-ending process. One such infection, caused by Candida spp. is candidiasis, which is a public health problem. Additionally, many strains have resistance to traditional therapies. Therefore, we tested the antifungal activity of four compounds present in Mentha spp. with promising antifungal precedents. We measured inhibition of growth by microdilution, disruption of biofilm viewed by electron microscopy, inhibition of germ tube formation by optical microscopy and toxicity on HaCaT cells. Tests showed that the compounds tested had antifungal activity with a minimum inhibitory concentration of 0.5 mg/mL, at least, 50% of biofilm inhibition in the 0.5 mg/mL concentration, an inhibition of polymorphism to 86% and the changes in the cell envelope of yeast (SEM) and cell viability above 50% among the Candida strains tested. Therefore, the compounds exhibit promising antifungal properties and provide a reasonable therapeutic window to be used in association with other traditional antimitotic.

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Section: Discussionmentioning

confidence: 86%

Antifungal and cytotoxic activity of purified biocomponents as carvone, menthone, menthofuran and pulegone from Mentha spp.

Boni¹,

Feiria²,

Santana³

et al. 2016

Afr. J. Plant Sci.

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“…and piperitenone oxide only have been found to possess antiparasitic activity (Matos-Rocha et al, 2013;de Sousa et al, 2016) and insecticidal properties against mosquitoes and weevils (Tripathi et al, 2004;Lima et al, 2014;Zekri et al, 2013). Conversely, it weakly contributed to the cytotoxicity of the Mentha villosa essential oil against human cancer cell lines (Amaral et al, 2015). Interestingly, this monoterpene exhibited antibacterial, antiviral and antifungal activities (Arruda et al, 2006: Civitelli et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Genotoxicity assessment of piperitenone oxide: An in vitro and in silico evaluation

Sotto

Giacomo

Abete

et al. 2017

Food and Chemical Toxicology

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Piperitenone oxide, a natural flavouring agent also known as rotundifolone, has been studied for the genotoxicity assessment by an integrated in vitro and in silico experimental approach, including the bacterial reverse mutation assay, the micronucleus test, the comet assay and the computational prediction by Toxtree and VEGA tools. Under our experimental conditions, the monoterpene showed to induce both point mutations (i.e. frameshift, base-substitution and/or oxidative damage) and DNA damage (i.e. clastogenic or aneuploidic damage, or single-strand breaks). Computational prediction for piperitenone oxide agreed with the toxicological data, and highlighted the presence of the epoxide function and the α,β-unsaturated carbonyl as possible structural alerts for DNA damage. However, improving the toxicological libraries for natural occurring compounds is required in order to favour the applicability of in silico models to the toxicological predictions. Further in vivo evaluations are strictly needed in order to evaluate the role of the bioavailability of the substance and the metabolic fate on its genotoxicity profile. To the best of our knowledge, these data represent the first evaluation of the genotoxicity for this flavour compound and suggest the need of further studies to assess the safety of piperitenone oxide as a flavouring agent.

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“…Cancer is a disease characterized by uncontrolled multiplication of subtly modified normal human cells (Mubeen et al, 2012). An exceptionally difficult problem in cancer treatment is multidrug resistance, when cancer cells lose their sensitivity to multiple structurally different chemotherapeutics, leading to the search for alternative treatments, such a medicinal plants (Amaral et al, 2015). Plants have a long history of use in the treatment of cancer and the interest in nature as a source of potential chemotherapeutic agents continues.…”

Section: Introductionmentioning

confidence: 99%

In vivo antitumor effect of the aqueous extract of Punica granatum in the sarcoma 180 murine model

Bastos¹,

Costa²,

Valois³

et al. 2018

J. Med. Plants Res.

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Punica granatum, specifically the fruit, has a long ethno medical history and is a phytochemical reservoir of great medicinal value. The phytochemistry and pharmacological actions of all P. granatum components suggest a wide range of clinical applications. The aim of the present study is to investigate the anticancer potential of aqueous extract of P. granatum (AEPG) in experimental models. The chemical composition of the AEPG was assessed by HPLC-DAD. In vivo antitumor activity was assessed in sarcoma 180 bearing mice. To evaluate the toxicological aspects related to the AEPG treatment, hematological, biochemical, histopathological and morphological analyses of treated animals were performed. Gallic acid, punicalagin α, punicalagin β, and ellagic acid were identified as the major phytochemical compounds of the extract. AEPG and 5-fluorouracil (5-FU) induced significant inhibition of tumor growth when compared with saline (p < 0.05). The percentage of apoptotic cells was significantly increased in 5-FU (p < 0.01) and AEPG treated groups (p < 0.01). No significant difference was observed between 5-FU and the three doses of AEPG. 5-FU induced toxic effects, such as decrease of body weight, splenic atrophy, and leukopenia, but these effects were not found in AEPG treated groups. The results provide evidence that AEPG exhibits comparable antitumor effects as 5-FU in a murine model, likely the result of increased apoptotic rate, but with no remarkable side effects presented by 5-FU.

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Evaluation of the cytotoxic and antitumour effects of the essential oil from Mentha x villosa and its main compound, rotundifolone

Abstract: The EOMV possesses significant antitumour activity with low systemic toxicity, possibly due to the synergistic action of its minor constituents.

Cited by 18 publications

References 31 publications

Antifungal and cytotoxic activity of purified biocomponents as carvone, menthone, menthofuran and pulegone from Mentha spp.

Antifungal and cytotoxic activity of purified biocomponents as carvone, menthone, menthofuran and pulegone from Mentha spp.

Genotoxicity assessment of piperitenone oxide: An in vitro and in silico evaluation

In vivo antitumor effect of the aqueous extract of Punica granatum in the sarcoma 180 murine model

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