Evaluation of the cytotoxicity on breast cancer cell of extracts and compounds isolated from Hyptis pectinata (L.) poit

Abstract

Hyptis pectinata is a herb popularly used in Brazil for the treatment of inflammations, pain, bacterial infections and cancer. In the present study, inflorescences (MPIn), leaves (MPL), branches (MPB), root (MPR) extracts and three compounds isolated from MPIn were assayed against breast tumor cell lines. The structures of the three compounds (pectinolide J, hyptolide and pectinolide E) were determined by means of spectroscopic analysis. Pectinolide J was isolated for the first time. The MPIn, MPL and MPR exhibited specific antiproliferative activity on tumor cell lines when compared to normal cell lines with IC 50 of 52.01 ± 0.64, 45.91 ± 0.02 g/mL and 82.84 ± 0.03 g/mL, respectively. Although the isolated substances did not present good antiproliferative activity, when the three were associated, a greater biological effect was observed, suggesting a synergistic effect. Hyptolide (5.6±0.4 g/mL) showed IC 50 sufficiently low to be considered as a drug prototype.

New derivatives of a natural nordentatin

“…Esterification of nordentatin (1) was carried out by an acylation method [6,15] (Figure 1). First, around 100 mg of sample (1) was put in each flask.…”

“…Inhibitors of α-glucosidase such as voglibose, miglitol, and acarbose are currently used clinically, but their use is limited due to their adverse effects, such as diarrhea, abdominal cramping, flatulence, and vomiting. Therefore, much effort has been focused to develop effective α-glucosidase inhibitors from natural sources [13][14][15].…”

“…Cancer, in its various forms, is one of the major causes of death of the human population. Among them, cervical and breast cancers are the most common causes of cancer-related deaths in women globally [15,17]. Several natural products of plant origin could potentially be used as cancer chemotherapeutic agents.…”

Cytotoxic Activity of Hyptis Pectinate Extracts on MCF-7 Human Breast Cancer Cells

“…Hyptis pectinata (L.) poit has more than 400 species distributed in tropical climates such as Indonesia, 146 are endemic to brazil and popularly known as "sambacaita" (Porter, et al, 1995;Pålsson and Jaenson, 1999;De Almeida and De Albuquerque, 2002). Hyptis pectinata is a medicinal plant popularly used for anticancer, antioxidant, anti-inflammatory, antiociceptive, and antimicrobial (Miranda, et al, 1993;Santos, et al, 2008;Raymundo, et al, 2011;Santana, et al, 2019). Hyptis pectinata extract (HPE) is capable on inhibiting the growth of human colon carcinoma cell line (HCT-8) with moderate cytotoxic activity (Barbosa, et al, 2012).…”

Avaliação da atividade antimicrobiana da planta hyptis pectinata: Uma revisão da literatura sistemática

“…A planta Hyptis pectinata é uma erva bastante cultivada no Brasil para o tratamento de inflamações, dores, infecções bacterianas e câncer (Santana et al, 2019). Possui características aromáticas, e pode ser cultivada em seu próprio quintal de casa, mas geralmente seu crescimento acontece de forma natural em volta as matas, diversas pesquisas comprovam que o extrato aquoso de suas folhas possui ricas composições para o uso medicinal (Mann et al, 2002).…”