Evaluation of the dentinal bridge after pulpotomy andcalcium hydroxide dressing

Goldberg, Fernando; Massone, E.; Spielberg, Carlos

doi:10.1016/s0099-2399(84)80186-7

Cited by 52 publications

(30 citation statements)

References 6 publications

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“…The remnant calcium hydroxide-based materials (Calcicur ® , Calcimol LC ® ) showed a reduction in the percentage of cell viability after 72 h, suggesting a different rate of biocompatibility long-term. Although Cavalcanti et al (35) reported lesser cytotoxic effects for calcium hydroxide compared to adhesive pulp-capping materials our results confirm the conclusions of other authors (36)(37)(38) regarding the non-complete biocompatibility of calcium hydroxide-based materials. Calcium hydroxide is important in protecting the pulp from thermal, mechanical, and microbiological stimuli (4) because of its antibacterial action and its property of stimulating sclerotic and reparative dentin formation.…”

Section: Discussionsupporting

confidence: 89%

In vitro cytotoxicity evaluation of different pulp capping materials: a comparative study

Poggio

Ceci

Dagna

et al. 2015

Archives of Industrial Hygiene and Toxicology

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Direct pulp capping covers the exposed surface of the pulp to maintain its vitality and preserve its functional and biologic activity. The aim of the present study was to compare the biocompatibility effects of seven different pulp-capping materials in vitro: Dycal®, Calcicur®, Calcimol LC®, TheraCal LC®, ProRoot MTA®, MTA-Angelus®, and Biodentine®. Using the Transwell insert methodology by Alamar blue test, we evaluated the cytocompatibility of the above mentioned materials towards murine odontoblasts cells (MDPC-23) at three different times (24, 48, and 72 h). For additional control, the cell viability at 72 hours was also assessed by MTT assay. Morphological analysis of murine odontoblasts was assessed by Confocal Laser Scanning Microscope. The results indicate significantly different biocompatibility among materials with different composition. Biodentine® and mineral trioxide aggregate (MTA)-based products showed lower cytotoxicity, varying from calcium hydroxide-based materials, which exhibited higher cytotoxicity. Although our findings are limited to in vitro conditions, the observation that Biodentine® caused a cytotoxic effect similar to MTA suggests that it may be considered an alternative in pulp-capping treatment, as calcium hydroxide-based materials present higher cytotoxic effects.

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Section: Discussionsupporting

confidence: 89%

In vitro cytotoxicity evaluation of different pulp capping materials: a comparative study

Poggio

Ceci

Dagna

et al. 2015

Archives of Industrial Hygiene and Toxicology

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“…However, formation of a calcific barrier could be interpreted either as a healing process or as a reaction to irritation 19,20) . Further, the dental pulp tissue could come into contact with the coronal aspects of the calcific barrier via tubular defects therein 21) . Therefore, we included criteria for evaluation of the dental pulp, i.e., inflammation, congestion, and patterns of odontoblast-like cells.…”

Section: Discussionmentioning

confidence: 99%

Biological efficacy of two mineral trioxide aggregate (MTA)-based materials in a canine model of pulpotomy

Lee

Kang

Song

et al. 2017

Dental Materials Journal

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The aim of this study was to compare the biocompatibility of Endocem Zr ® and ProRoot MTA ® by histopathologic analysis in a canine model of pulpotomy. This study utilized 39 teeth of two beagle dogs. The exposed pulp tissues were treated by pulpotomy using ProRoot MTA (n=19) or Endocem Zr (n=20). After 8 weeks, the teeth were extracted and processed with hematoxylin-eosin staining for histologic evaluation. Most of the specimens in both groups developed a calcific barrier at the pulp amputation site and formed an odontoblast layer. However, some of the Endocem Zr specimens showed less calcific barrier formation with a greater inflammatory response and less odontoblast layer formation when compared with the ProRoot MTA specimens. ProRoot MTA and Endocem Zr specimens developed a calcific barrier; however, ProRoot MTA was more biocompatible than Endocem Zr.

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“…But, the results did not change in a concentration-dependent manner. It has been reported that tertiary dentin was induced by direct pulp capping with conventional calcium hydroxide have the tunnel-shaped defects present in approximately 90% 12,13) , and about 40% of them cause pulpitis 37) . These results suggest quality of the tertiary dentin becomes necessary conditions may not cause degeneration of the pulp and pulp reinfection by leakage through the loss of tertiary dentin.…”

Section: Discussionmentioning

confidence: 99%

“…However, calcium hydroxide has highly alkaline (pH12), which can be formed below of pulp necrosis following cause chronic inflammation and formed internal absorption layer. To make matters worse, the tertiary dentin which is formed so as to cover the surface of exposed pulp as a protective response have such as defects and tunnel-like shaped, their presence will be caused for deterioration of pulp disease [12][13][14][15] . Therefore, development of highly secure direct pulp capping agent to induce the high quality tertiary dentin more effectively has been demanded.…”

Section: Introductionmentioning

confidence: 99%

The possibility of genistein as a new direct pulp capping agent

et al. 2013

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Genistein, kind of soy isoflavones, is well-known as natural ingredients and consumed as health foods and supplements. They are expected to improve renal function. They have high-affinity to estrogen receptor β expressed predominantly in bone tissue, they prevent osteoporosis specifically and safely. We examined whether genistein can be a new direct capping agent. In this study, we examined the effect of genistein for the proliferation and differentiation of rat dental pulp cells in vitro and the ability of tertiary dentin formation in vivo. As a result, rat dental pulp cells with genistein were increased activity of ALPase and showed alizarin red positive-staining. Calcification-related genes expression has been confirmed by the addition of genistein. From in vivo study, high quality of tertiary dentin formation and minor pulp reaction were observed. From these findings, it was suggested that genistein may be useful agent for direct pulp capping.

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Evaluation of the dentinal bridge after pulpotomy andcalcium hydroxide dressing

Cited by 52 publications

References 6 publications

In vitro cytotoxicity evaluation of different pulp capping materials: a comparative study

In vitro cytotoxicity evaluation of different pulp capping materials: a comparative study

Biological efficacy of two mineral trioxide aggregate (MTA)-based materials in a canine model of pulpotomy

The possibility of genistein as a new direct pulp capping agent

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