Evaluation of the Dependence of Autoantibody Levels and Cytokines From the Inhalation Load of Priority Toxicants Air Environment

Abstract

Air pollution has a negative impact on the human body, creating the preconditions for the formation of adaptive processes or the occurrence of pathologies. Formaldehyde, particulate matter, nitrogen oxide were proved to have an effect on the respiratory and immune systems, the latter played a key role in the formation of adaptive reactions. The purpose of the study was to assess the effect of formaldehyde, nitrogen dioxide and particulate pollutants in the air environment, the maintenance of specific autoantibodies and cytokines by means of a mathematical model. The study included 659 students. In assessing individual inhalation of chemical loadings on an organism of adolescents into account data on the content of impurities in the ambient air, indoor air, information about the organization of educational process and rest pupils, anthropometric and spirometric parameters. The content of interleukin-2 and -10, interferon - alpha and - gamma, level of specific autoantibodies that characterize the state of the immune system and lungs has been studied in adolescents. The content of specific autoantibodies and cytokines depends upon hazard indexes priority pollutants are not linear and varies depending on the level of exposure of toxicants. The levels of autoantibodies to β2- glycoprotein I and the content of α-INF and γ-INF adolescents living in air pollution by formaldehyde, nitrogen dioxide, and particulate matter may depend on the level of inhaled pollutants load by 8-11%. Inhalation of nitrogen dioxide in the organism of adolescents may contribute to the variable level of autoantibodies to the of membrane antigens lung parenchyma to 22%.

Cytokine regulation of inflammatory processes in respiratory organs of rats exposed to the combined inhalation of chemicals in low concentrations

“…Согласно литературным данным, изучение адаптационных и патологических процессов в организме человека при ингаляционном воздействии вредных химических веществ часто проводят с использованием цитокинового профиля в сыворотке крови [2,[4][5][6]. В модельных исследованиях с животными используют, как правило, морфологические исследования органов дыхания [7,8].…”