Evaluation of the Diagnostic and Predicative Values of 8-Iso-Prostaglandin F2α as a Biomarker of Breast Cancer

Abstract

Background: Breast cancer (BC) is a commonly reported cancer that is widely prevalent among women. Its early detection improves patient survival and results in better outcomes. For diagnosis and follow-up care, tumor markers are one of the feasible investigations to be ordered. 8-Iso-prostaglandin F2α (8-iso-PGF2α) serves as a serum marker reflecting oxidative stress and subsequent damaging of DNA. In the present study, we aimed to evaluate both diagnostic and predictive values of 8-iso-PGF2α in BC patients. Materials and Methods: Serum levels of 8-iso-PGF2α were assessed for 66 women with benign breast tumors and 65 women who had malignant BC. To compare the patients who had breast tumors with healthy individuals, 63 women free of breast diseases were selected as controls. Results: The serum level of 8-iso-PGF2α in the BC patients (57.92 pg/mL) was significantly higher compared to those with benign tumors (18.89 pg/mL) (p < 0.001). In addition, individuals with no breast diseases had less 8-iso-PGF2α (4.02 pg/mL) compared to those who had developed a tumor (p < 0.001). Serum 8-iso-PGF2α was found to be positively correlated with both carcinoembryonic antigen (r = 0.74, p < 0.001) and cancer antigen 15-3 (r = 0.80, p < 0.001). Furthermore, serum 8-iso-PGF2α showed high diagnostic performance in BC (AUC = 0.999, sensitivity = 100%, specificity = 99.2% at a cutoff value of 36.18 pg/mL). Conclusions: Our study found that the high level of serum 8-iso-PGF2α helps to provide a noninvasive indicator to detect BC. Future work with a larger sample size and various phases of BC can confirm the current results which provide insights into the early detection of cancer.

Deficiency of antioxidants and increased oxidative stress in COVID-19 patients: A cross-sectional comparative study in Jigawa, Northwestern Nigeria

“…This study also revealed that COVID-19 co-infected with malaria was the highest comorbidity recorded; this may be due to malaria being pandemic in the region coupled with fragile healthcare delivery and poor malaria control programs. In another study on factors which increase production of ROS such as malaria, Nour Eldin et al 44 reported increased lipid peroxidation and elevated level of 8-iso-PGF2α. Similarly, our research revealed significantly increased levels of 8-iso-PGF2α in COVID-19 co-infected with malaria compared to COVID-19 subjects without co-infection, lower levels of antioxidant vitamins were also noted among the co-infected group compared to COVID-19 naïve.…”

The Role of Prostaglandins in Different Types of Cancer

“…8-Iso-prostaglandin F 2a (8-iso-PGF 2α ) serves as a serum non-invasive marker reflecting oxidative stress and subsequent damaging of DNA. The serum level of 8-iso-PGF 2α in the breast cancer patients (57.92 pg/mL) was significantly higher compared to those with benign tumors (18.89 pg/mL) (p < 0.001) [43].…”

Fatty acids in cancer: Metabolic functions and potential treatment

“…In addition to promoting proliferation, further studies have shown that prostaglandin F2α (PGF2ɑ) can increase the invasion of carcinoma‐derived cells in colorectal cancer 120 . Additionally, it has been found that PGF2ɑ also has the potential as a breast cancer biomarker 144 . However, some PGs are considered to be antitumorigenic.…”

“…120 Additionally, it has been found that PGF2ɑ also has the potential as a breast cancer biomarker. 144 However, some PGs are considered to be antitumorigenic. For example, prostaglandin D2 (PGD 2 ) has been reported to reduce pancreatic tumorigenesis.…”