Evaluation of the diagnostic value of serum and tissue apoptotic cytokeratin-18 in patients with chronic hepatitis C

Haleem, Hanan Abdel; Hafez, Hassan A.; Fouad, Ahmed; Akl, Maha; Hassan, Mona M.; Hammam, Olfat; Morsy, A. T. A.; Saleh, Azza; Seyam, Moataz; Zakaria, Zeinab; Zakaria, Soher

doi:10.1016/j.ajg.2013.03.004

Cited by 10 publications

(6 citation statements)

References 24 publications

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“…In the final selection step, eight out of 11 studies were identified, with three articles being abandoned for not supplying enough information. These eight case-control studies, in full text, fulfilled our selection criteria, ultimately providing information on the correlation of serum CK-18 levels with hepatitis between 2010 and 2014 ( 8 , 11 , 15 , 23 - 25 , 29 , 30 ). Demographic information on hepatitis patients, baseline characteristics and methodological quality of the enrolled studies are listed in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…On the ground of these relative properties of hepatitis and CK-18, there were increasing reports speculating that CK-18 can be used as a noninvasive diagnostic marker for predicting the staging of chronic liver diseases. For example, a previous study has shown that CK-18 serum levels are increased in CHC development and the higher grades of chronic inflammation are correlated with overexpression of CK-18 within hepatocytes, suggesting that CK-18 has great predictive value in the diagnosis of hepatitis severity ( 11 ). Furthermore, the degree of liver damage because of hepatitis may decide fibrosis severity, which reveals elevated expression of CK-18 in CHB patients, and therefore CK-18 concentrations are implicated with the detection of liver fibrosis and has a significant utility in defining the pathological features of CHB patients, in the clinic ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

“…( 7 , 9 , 10 ). Recently, cytokeratin-18 (CK-18), which is important for hepatocyte integrity, has been demonstrated to be implicated in the development of hepatitis ( 11 , 12 ).…”

Section: Introductionmentioning

confidence: 99%

“…From all the aspects, we postulated that serum CK-18 levels may be implicated in the progress of hepatitis. Several studies held the view that serum CK-18 levels might be a useful biomarker in assessing liver damage in hepatitis ( 23 , 24 ), while other documents failed to support this finding ( 11 , 25 ).…”

Section: Introductionmentioning

confidence: 99%

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Clinical Values of Elevated Serum Cytokeratin-18 Levels in Hepatitis: a Meta-Analysis

Yang

Qin

et al. 2015

Hepat Mon

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Background:As an important intermediate filament protein within liver cells, cytokeratin-18 (CK-18) has been confirmed as a potential indicator in various hepatitis progressions.Objectives:We sought to clarify the connection between serum CK-18 levels and hepatitis pathogenesis in the present meta-analysis.Materials and Methods:With the application of various computerized databases, including PubMed, Embase, Cochrane Library, Google Scholar, Web of Science, China BioMedicine (CBM), China National Knowledge Infrastructure (CNKI), published papers that assessed the relationship between serum CK-18 levels and hepatitis were obtained. The main key words used are “Hepatitis”, “hepatitides”, “Cytokeratin-18”, “Keratin-18” and “CK-18”. Statistical analysis was conducted using the STATA software (version 12.0).Results:Eight case-control studies published between 2010 and 2014 were confirmed eligible, according to our selection criteria. The results of the meta-analysis showed that serum levels of CK-18 in hepatitis patients were higher compared to healthy controls (standardized mean difference (SMD) = 3.71, 95%CI: 2.27-5.14, P < 0.001). Subgroup analysis by ethnicity and disease implicated that high serum CK-18 levels might be a risk factor for non-alcoholic steatohepatitis (NASH), chronic hepatitis C (CHC), and chronic hepatitis B (CHB) (all P < 0.05) among Asians (SMD = 2.89, 95%CI: 2.35-3.43, P < 0.001), Africans (SMD = 0.69, 95%CI: 0.12-1.26, P = 0.017), and Caucasians (SMD = 4.86, 95%CI: 1.82-7.89, P = 0.002).Conclusions:Serum CK-18 levels in hepatitis patients were higher, compared with healthy controls. Our results revealed the clinical values of CK-18, in combination with other apoptosis markers, in identifying the development of hepatitis.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…( 7 , 9 , 10 ). Recently, cytokeratin-18 (CK-18), which is important for hepatocyte integrity, has been demonstrated to be implicated in the development of hepatitis ( 11 , 12 ).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical Values of Elevated Serum Cytokeratin-18 Levels in Hepatitis: a Meta-Analysis

Yang

Qin

et al. 2015

Hepat Mon

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“…[19] Another study reported that M65 and M30 were helpful in detecting liver inflammation in viral hepatitis. [20] Kronenberger et al [15] and Abdel Haleem et al [21] found that serum CK-18 neoepitope levels in CHC were strongly correlated with ALT and the histology activity index. The level of CK-18 neoepitope was significantly higher in CHC patients with elevated ALT levels than in those with normal ALT.…”

Section: Discussionmentioning

confidence: 99%

Cell death biomarker M65 is a useful indicator of liver inflammation and fibrosis in chronic hepatitis B

Wei

Lin

et al. 2017

Medicine

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Cell death markers, M65 and M30, have been suggested to be sensitive markers of liver inflammation and fibrosis in nonalcoholic fatty liver disease and chronic hepatitis C. Our aim was to investigate whether these markers were useful in diagnosing liver inflammation and fibrosis in chronic hepatitis B (CHB).We examined 186 patients with CHB; 18 sex- and age-matched healthy subjects were controls. The blood samples were collected from CHB patients within 1 week before or after liver biopsy. According to METAVIR score system, liver inflammation was graded from A0 to A3, and fibrosis from F0 to F4.Serum M65 and M30 levels were in parallel with the grades of liver inflammation. M65, not M30, increased significantly in patients with severe inflammation and normal alanine aminotransferase. M65 is one of the independent predictors of severe liver inflammation (≥A2). The levels of M65 and M30 levels significantly increased in parallel with the degree of inflammation in F1 patients, whereas they showed no statistical difference between different stages of fibrosis in A1 patients.Serum M65 is a useful indicator of liver inflammation in CHB patients. Serum M65, not M30, is valuable in the grading of liver fibrosis.

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Molecular mechanisms of hepatic apoptosis regulated by nuclear factors

Wang

2015

Cellular Signalling

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Evaluation of the diagnostic value of serum and tissue apoptotic cytokeratin-18 in patients with chronic hepatitis C

Cited by 10 publications

References 24 publications

Clinical Values of Elevated Serum Cytokeratin-18 Levels in Hepatitis: a Meta-Analysis

Clinical Values of Elevated Serum Cytokeratin-18 Levels in Hepatitis: a Meta-Analysis

Cell death biomarker M65 is a useful indicator of liver inflammation and fibrosis in chronic hepatitis B

Molecular mechanisms of hepatic apoptosis regulated by nuclear factors

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