Evaluation of the early-phase [18F]AV45 PET as an optimal surrogate of [18F]FDG PET in ageing and Alzheimer’s clinical syndrome

Vanhoutte, Matthieu; Landeau, Brigitte; Sherif, Siya; Sayette, Vincent de La; Dautricourt, Sophie; Abbas, Ahmed M.; Manrique, Alain; Chocat, Anne; Chételat, Gaël

doi:10.1016/j.nicl.2021.102750

Cited by 9 publications

(45 citation statements)

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“…Overall, 12 AD patients and 10 controls underwent lumbar puncture for CSF collection, and the other 18 underwent Florbetapir F-18 (18F-AV-45) positron emission tomography (PET)-computed tomography or PET–magnetic resonance scanning. A low CSF Aβ42 level or a positive 18F-AV-45 PET scan, which showed a high binding affinity and specificity to Aβ plaques, were additional requirements for inclusion in the AD group to confirm that patients had amyloid deposition in the brain [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

Identification of Candidate Biomarkers of Alzheimer’s Disease via Multiplex Cerebrospinal Fluid and Serum Proteomics

Liu,

Li,

et al. 2023

IJMS

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Alzheimer’s disease (AD) is the most prevalent form of dementia among elderly people worldwide. Cerebrospinal fluid (CSF) is the optimal fluid source for AD biomarkers, while serum biomarkers are much more achievable. To search for novel diagnostic AD biomarkers, we performed a quantitative proteomic analysis of CSF and serum samples from AD and normal cognitive controls (NC). CSF and serum proteomes were analyzed via data-independent acquisition quantitative mass spectrometry. Our bioinformatic analysis was based on Gene Ontology (GO) functional annotation analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment. In comparison to the controls, 8 proteins were more abundant in AD CSF, and 60 were less abundant in AD CSF, whereas 55 proteins were more and 10 were less abundant in the serum samples. ATPase-associated activity for CSF and mitochondrial functions for CSF and serum were the most enriched GO terms of the DEPs. KEGG enrichment analysis showed that the most significant pathways for the differentially expressed proteins were the N-glycan biosynthesis pathways. The area under the curve (AUC) values for CSF sodium-/potassium-transporting ATPase subunit beta-1 (AT1B1), serglycin (SRGN), and thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3) were 0.867 (p = 0.004), 0.833 (p = 0.008), and 0.783 (p = 0.025), respectively. A panel of the above three CSF proteins accurately differentiated AD (AUC = 0.933, p = 0.001) from NC. The AUC values for serum probable phospholipid-transporting ATPase IM (AT8B4) and SRGN were moderate. The AUC of the CSF SRGN + serum SRGN was 0.842 (p = 0.007). These novel AD biomarker candidates are mainly associated with inflammation, ATPase activity, oxidative stress, and mitochondrial dysfunction. Further studies are needed to investigate the molecular mechanisms by which these potential biomarkers are involved in AD.

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Section: Methodsmentioning

confidence: 99%

Identification of Candidate Biomarkers of Alzheimer’s Disease via Multiplex Cerebrospinal Fluid and Serum Proteomics

Liu,

Li,

et al. 2023

IJMS

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“…We also investigated, if significant associations between the VRF of interest and changes in RSFC over time were moderated by Aβ burden. Therefore, we dichotomized participants with an Aβ-PET SUVR ≥ 1.22 into Aβ-positive individuals and < 1.22 into Aβ-negative individuals, using thresholds that were established and described in our previous study ( Vanhoutte et al, 2021 ). Then the models described above were rerun, except that the term “Aβ-PET SUVR × time” was replaced by a 3-way interaction between the vascular risk factor of interest (i.e., that was significantly associated with RSFC in the first models), Aβ positivity status and time.…”

Section: Methodsmentioning

confidence: 99%

Vascular Health Is Associated With Functional Connectivity Decline in Higher-Order Networks of Older Adults

Wirth

Gaubert

Köbe

et al. 2022

Front. Integr. Neurosci.

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BackgroundPoor vascular health may impede brain functioning in older adults, thus possibly increasing the risk of cognitive decline and Alzheimer’s disease (AD). The emerging link between vascular risk factors (VRF) and longitudinal decline in resting-state functional connectivity (RSFC) within functional brain networks needs replication and further research in independent cohorts.MethodWe examined 95 non-demented older adults using the IMAP+ cohort (Caen, France). VRF were assessed at baseline through systolic and diastolic blood pressure, body-mass-index, and glycated hemoglobin (HbA1c) levels. Brain pathological burden was measured using white matter hyperintensity (WMH) volumes, derived from FLAIR images, and cortical β-Amyloid (Aβ) deposition, derived from florbetapir-PET imaging. RSFC was estimated from functional MRI scans within canonical brain networks at baseline and up to 3 years of follow-up. Linear mixed-effects models evaluated the independent predictive value of VRF on longitudinal changes in network-specific and global RSFC as well as a potential association between these RSFC changes and cognitive decline.ResultsWe replicate that RSFC increased over time in global RSFC and in the default-mode, salience/ventral-attention and fronto-parietal networks. In contrast, higher diastolic blood pressure levels were independently associated with a decrease of RSFC over time in the default-mode, salience/ventral-attention, and fronto-parietal networks. Moreover, higher HbA1c levels were independently associated with a reduction of the observed RSFC increase over time in the salience/ventral-attention network. Both of these associations were independent of brain pathology related to Aβ load and WMH volumes. The VRF-related changes in RSFC over time were not significantly associated with longitudinal changes in cognitive performance.ConclusionOur longitudinal findings corroborate that VRF promote RSFC alterations over time within higher-order brain networks, irrespective of pathological brain burden. Altered RSFC in large-scale cognitive networks may eventually increase the vulnerability to aging and AD.

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“…임상에서 아밀로이드 PET가 사용되기 전에는 알츠하이머병의 진단에서 FDG PET를 주로 사용하여 신경퇴행을 평가하였으나, 아밀로이드병리의 정보를 함께 얻기 위해서 FDG PET와 아밀로이드 PET를 모두 얻는 경우 시간적 경제적 부담과 방사선 노출이 증가할 수밖에 없다. 현재 사용되고 있는 아밀로이드 영상용 방사성 의약품들은 지질친화도가 높아 정맥 주사 후 매우 짧은 시간 이내에 뇌로 들어가는데, 주사 후 초기 섭취는 뇌혈류량을 반영하게 되고, 이는 FDG PET에서 측정되는 뇌포도당대사와 잘 매칭된다( 33 34 ). Fig.…”

Section: 아밀로이드 Pet의 임상적 평가과 응용unclassified

Recent Updates on PET Imaging in Neurodegenerative Diseases

Kim

2022

J Korean Soc Radiol

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Evaluation of the early-phase [18F]AV45 PET as an optimal surrogate of [18F]FDG PET in ageing and Alzheimer’s clinical syndrome

Cited by 9 publications

References 58 publications

Identification of Candidate Biomarkers of Alzheimer’s Disease via Multiplex Cerebrospinal Fluid and Serum Proteomics

Identification of Candidate Biomarkers of Alzheimer’s Disease via Multiplex Cerebrospinal Fluid and Serum Proteomics

Vascular Health Is Associated With Functional Connectivity Decline in Higher-Order Networks of Older Adults

Recent Updates on PET Imaging in Neurodegenerative Diseases

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