Evaluation of the effect of systemic omega-3 polyunsaturated fatty acids on post-orthodontic relapse in a rabbit model

Gad, Asser; Abdallah, Essam; El-Harouni, Nadia; Soliman, Samia

doi:10.21608/eos.2018.77151

Cited by 1 publication

(3 citation statements)

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“…Also, Moon et al (12) found that CoQ10 suppressed osteoclastogenesis in an in-vitro cellular level study. Similarly, Gad et al (37) found significant reduction in the osteoclast count along the relapse pressure side in the experimental group of rabbits after omega-3 systemic administration. A significant decline in the number of osteoclast was also found when PRP was tested to evaluate its effect on orthodontic relapse (38).…”

Section: Discussionmentioning

confidence: 70%

“…The present events of increasing vascularity, alveolar bone remodelling, enhancing osteogenesis and osteoblastic activity, decreasing osteoclastic activity and down-regulating bone resorption were matching to the histological findings resulted in studies testing other agents for minimizing orthodontic relapse in experimental rabbits ( 20,37,38,39). In both groups, the experimental and control, the moved teeth showed post-orthodontic relapse toward their original positions after removal of the orthodontic appliance.…”

Section: Discussionmentioning

confidence: 74%

“…The relapse amounts and percentages in the experimental group were less than that of the control group after 1 and 3 weeks of relapse, however, this difference was not statistically significant. The systematic administration of omega-3 polyunsaturated fatty acids in rabbits (37), was tested to reveal its effect on relapse of tooth movement. Similar results were obtained regarding the amounts and percentages of relapse after 1 and 3 weeks of relapse which is similar to the current results, except for the relapse percentage after 3 weeks which was significantly less in the experimental group than control group.…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Systemic Administration of Co-enzyme Q10 on Orthodontic Relapse in a rabbit model

Madian

Abdallah

Harouni

et al. 2021

Alexandria Dental Journal

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INTRODUCTION: Several pharmacological agents have been investigated for their ability to reduce orthodontic relapse. OBJECTIVE: The current research was performed to test the short term influence of systemic Co-enzyme Q10 administration on post-orthodontic relapse in rabbits. MATERIALS AND METHODS : Thirty New Zealand rabbits were randomly divided into 2 groups (n=15) : Experimental receiving Co-enzyme Q10 and control receiving control vehicle. Orthodontic tooth movement was performed using NiTi coil spring for 21 days for both groups, then this coil spring was detached, and teeth were allowed to relapse for another 21 days. Amounts and percentages of relapse were assessed on threedimensional models of the experimental and control groups at two time points (T2: 1 week of relapse) and (T3: three weeks of relapse). Animals were sacrificed after 3 weeks of relapse for histological examination using H&E stain. Also, histomorphometric analysis was performed. Statistical analysis was computed. Significance was judged at the 5% level. RESULTS: The amount and percentage of relapse showed insignificant difference among experimental and control groups, although relapse in the experimental group was less. However, the histological analysis showed that Co-enzyme Q10 resulted in significant reduction in osteoclast count with the area of new bone formation being significantly increased. Signs of bone resorption were more evident in the control group. CONCLUSION: From the present results, it could be concluded that Co-enzyme Q10 is capable of altering bone resorption pattern favorably in spite of its short term ineffectiveness in minimizing relapse.

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Section: Discussionmentioning

confidence: 70%