Evaluation of the effect of a 0.0584% hydrocortisone aceponate spray on clinical signs and skin barrier function in dogs with atopic dermatitis

Nam, Eui Hwa; Park, Seol Hee; Jung, Ji Young; Han, Seung Hee; Youn, Hwa Young; Chae, Jun Seok; Hwang, Cheol‐Yong

doi:10.4142/jvs.2012.13.2.187

Cited by 15 publications

(16 citation statements)

References 37 publications

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“…The numerical pruritus scale contained six categories of pruritic behaviour similar to that used in the validated PVAS10 method. 19,20 Lokivetmab administered at four week intervals was associated with decreases in the CADESI-04, pruritus and average TEWL values. When assessing response to treatment, it would seem reasonable to use the average TEWL calculated from several areas of the body given that a greater correlation is found in such cases.…”

Section: Discussionmentioning

confidence: 92%

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The influence of treatment with lokivetmab on transepidermal water loss (TEWL) in dogs with spontaneously occurring atopic dermatitis

Szczepanik

Wilkołek

Gołyński

et al. 2019

Veterinary Dermatology

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Background Atopic dermatitis (AD) is one of the most common skin diseases in dogs. Monitoring the progress of treatment may include assessment of lesion severity by use of Canine Atopic Dermatitis Extent and Severity Index (CADESI), assessment of pruritus and measurement of biophysical parameters of the skin. Hypothesis This study aimed to assess changes in transepidermal water loss (TEWL) during 12 weeks of treatment with lokivetmab and its correlation with the CADESI‐04 and the severity of pruritus. Animals Ten client‐owned dogs with canine AD. Methods and materials The animals were administered lokivetmab three times at four week intervals. Pruritus and CADESI‐04 were assessed, and TEWL was measured at six body regions, on Day 0 and repeated at weeks 4, 8 and 12. Results There was a significant decrease in the CADESI‐04 score, the severity of pruritus and the mean TEWL between baseline and each of the time points. TEWL also decreased in the majority of body sites examined. Significant correlations between the CADESI‐04 and mean TEWL (r = 0.519, P = 0.0003), and between pruritus severity and mean TEWL (r = 0.517, P = 0.0003), were found. Conclusions and clinical significance Overall TEWL decreased during lokivetmab treatment but not at all body sites. If TEWL is used to assess the effectiveness of a treatment, a mean TEWL score should be calculated from several areas of the body.

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Section: Discussionmentioning

confidence: 92%

“…We decided to use this scale to simplify the assessment of pruritus by the owners. The numerical pruritus scale contained six categories of pruritic behaviour similar to that used in the validated PVAS10 method …”

Section: Discussionmentioning

confidence: 99%

The influence of treatment with lokivetmab on transepidermal water loss (TEWL) in dogs with spontaneously occurring atopic dermatitis

Szczepanik

Wilkołek

Gołyński

et al. 2019

Veterinary Dermatology

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“…Treatment duration and frequency of use should be tailored to each patient; applications should normally continue until complete and stable remission of signs (SOR C). Basis for the updated recommendations: In addition to the previously available clinical trial data, a small study confirmed that a one to two-week daily application of an hydrocortisone aceponate spray (Cortavance, Virbac) significantly improved lesions and pruritus in atopic dogs (QOE 2) [ 10 ]. A.3.b.…”

Section: Introductionmentioning

confidence: 99%

Treatment of canine atopic dermatitis: 2015 updated guidelines from the International Committee on Allergic Diseases of Animals (ICADA)

et al. 2015

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BackgroundIn 2010, the International Task Force on Canine Atopic Dermatitis (now International Committee on Allergic Diseases of Animals, ICADA) published the first consensus guidelines for the treatment of atopic dermatitis (AD) in dogs. This is the first 5-year minor update of this document.ResultsThe treatment of acute flares of AD should involve the search for, and then elimination of, the cause of the flares, bathing with mild shampoos, and controlling pruritus and skin lesions with interventions that include topical and/or oral glucocorticoids or oclacitinib. For chronic canine AD, the first steps in management are the identification and avoidance of flare factors, as well as ensuring that there is adequate skin and coat hygiene and care; this might include more frequent bathing and possibly increasing essential fatty acid intake. The medications currently most effective in reducing chronic pruritus and skin lesions are topical and oral glucocorticoids, oral ciclosporin, oral oclacitinib, and, where available, injectable recombinant interferons. Allergen-specific immunotherapy and proactive intermittent topical glucocorticoid applications are the only interventions likely to prevent or delay the recurrence of flares of AD.ConclusionsThis first 5-year minor update of the international consensus guidelines for treatment of AD in dogs further establishes that the treatment of this disease is multifaceted, and that interventions should be combined for a proven (or likely) optimal benefit. Importantly, treatment plans are likely to vary between dogs and, for the same dog, between times when the disease is at different stages.Electronic supplementary materialThe online version of this article (doi:10.1186/s12917-015-0514-6) contains supplementary material, which is available to authorized users.

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“…Furthermore, studies have demonstrated that TEWL values decrease in remission during specific immunotherapy and non-specific anti-pruritus treatment (using cyclosporine) (Cornegliani et al 2012). A simultaneous decrease in CADESI and TEWL values during local treatment (using hydrocortisone aceponate and polyunsaturated fatty acids) was reported by Eui-Hwa Nam et al andTretter andMueller ( Tretter andMueller 2011, Nam et al 2012) The aim of the present study was the assessment of changes in transepidermal water loss in dogs treated with anti-pruritic drugs (cyclosporine A in a dose of 5 mg/kg BW).…”

Section: Introductionmentioning

confidence: 99%

The influence of non-specific anti-pruritus treatment with cyclosporine A on transepidermal water loss (TEWL) in natural atopic dermatitis in dogs

Zając¹,

Szczepanik²,

Wilkołek³

et al. 2015

Polish Journal of Veterinary Sciences

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Atopic dermatitis is a common allergic skin disease in dogs. Monitoring the progress of treatment and the assessment of the severity of disease symptoms are crucial elements of the treatment procedure. One of the common means of assessing the severity of the clinical signs of the disease is the CADESI 03. Research studies have pointed to a possibility of assessing the severity of skin lesions by means of measuring biophysical skin parameters such as TEWL, skin hydration and erythema intensity. The aim of the study was the assessment of changes in TEWL and CADESI values measured in ten different body regions during non-specific anti-pruritus treatment. The examination was performed on ten dogs with atopic dermatitis (age from 2.5 years to 7 years, mean age 3.8 years). The measurements were performed in the following body regions: the lumbar region, the right axillary fossa, the right inguinal region, the ventral abdominal region, the right lateral thorax region, the internal surface of the auricle, interdigital region of the right forelimb, cheek, bridge of nose and the lateral site of antebrachum. A statistically significant decrease in CADESI values was reported starting from the second week of treatment. In the case of the mean TEWL values, a fall was observed after one week of treatment in the ventral abdominal region and the interdigital region, after two weeks of treatment in the axillary fossa and the inguinal region, and after three weeks in the cheek and the lateral thorax region. There was no statistically significant decrease in TEWL values in the course of treatment in four other regions.

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Evaluation of the effect of a 0.0584% hydrocortisone aceponate spray on clinical signs and skin barrier function in dogs with atopic dermatitis

Cited by 15 publications

References 37 publications

The influence of treatment with lokivetmab on transepidermal water loss (TEWL) in dogs with spontaneously occurring atopic dermatitis

The influence of treatment with lokivetmab on transepidermal water loss (TEWL) in dogs with spontaneously occurring atopic dermatitis

Treatment of canine atopic dermatitis: 2015 updated guidelines from the International Committee on Allergic Diseases of Animals (ICADA)

The influence of non-specific anti-pruritus treatment with cyclosporine A on transepidermal water loss (TEWL) in natural atopic dermatitis in dogs

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