Evaluation of the effect of electron beam therapy on oxidative stress and some minerals in patients with type 2 diabetes mellitus

Abstract

Background: The study on the control and treatment of type 2 diabetes mellitus, as a growing metabolic disease in the world, is important. Oxidative stress and reactive oxygen species in uncontrolled diabetes can play a role in the consequences of diabetes such as neuropathy and nephropathy. The presence of minerals as bioactive compounds in the diet and their role in antioxidant enzymes can play a role in reducing the oxidative effects of diabetes. Electron beam therapy as an adjunct method can be effective in reducing free radicals and oxidative stress. Objective: The main purpose of this study was to investigate the effect of electron beam therapy on glucose, oxidative markers and some minerals, as bioactive compound, in people with type 2 diabetes mellitus. Methods: The study was performed on 30 volunteers with type 2 diabetes mellitus and 30 healthy volunteers as a control group. Serum samples from diabetic and control groups were assayed for glucose, hydrogen peroxide, reactive oxygen species and minerals such as iron, zinc, copper, magnesium and selenium binding protein before and after electron beam irradiation. ATP levels and NAD/NADH ratio were also evaluated. The mentioned parameters were measured by ELISA and calorimetric methods according to the relevant kit protocol. Electron beam therapy was performed using a linear accelerator. The used amount of energy was 9 MeV. The depth of treatment was 1.5 cm.Results: The results of electron beam therapy showed that the concentrations of glucose, reactive oxygen species, hydrogen peroxide, copper and iron were significantly (P value < 0.05) reduced in diabetics. Zinc levels in this group increased significantly (P value < 0.05). In control group, ATP levels were significantly (P value < 0.05) increased by electron beam therapy.Conclusion: According to the obtained results, electron beam therapy can be effective in reduction of oxidation indexes and thus reducing oxidative stress. Electron beam therapy can be effective in reducing the consequences of diabetes mellitus. Keywords: Electron beam therapy, Oxidative stress, Mineral, Type 2 diabetes mellitus

Impact of green technology on content of bioactive components in eggplant

“…We concur with the elucidation provided in the works of P.K. Ghosh [29] and others, wherein the inclusion of legume green manures is associated with a solubilizing impact on macronutrients-such as nitrogen, phosphorus, An increase in the functional activity of eggplant fruits because of the applied technology provides grounds for considering such fruits as a functional food, according to the definition of the Food Functional several chronic diseases [53][54].…”

Complications in patients with transfusion dependent thalassemia: A descriptive cross‐sectional study

“…Complications associated with beta‐thalassemia include iron overload, splenomegaly, growth retardation, immune system disorders, heart and renal failure, and liver disease 6,7 . Iron overload is a major concern for patients with TDT, as it can lead to severe complications such as endocrinopathy, cardiomyopathy, diabetes, auditory abnormalities, osteoporosis, and growth failure 6,8 . This occurs due to increased intestinal absorption of iron due to erythropoiesis, leading to its accumulation in various organs 9 .…”

“… 6 , 7 Iron overload is a major concern for patients with TDT, as it can lead to severe complications such as endocrinopathy, cardiomyopathy, diabetes, auditory abnormalities, osteoporosis, and growth failure. 6 , 8 This occurs due to increased intestinal absorption of iron due to erythropoiesis, leading to its accumulation in various organs. 9 Patients with TDT are particularly susceptible to iron overload, and iron levels in TDT patients can reach as high as 200 mg per unit.…”