Evaluation of the effect of co-administered paracetamol on the gastro-intestinal absorption and disposition of chloroquine

Research Progress of Chloroquine and Hydroxychloroquine on the COVID-19 and Their Potential Risks in Clinic Use

“…Based on previous reports, CQ is rapidly absorbed from the gastro-intestinal tract when administration via oral route ( Essien et al, 1988 ). The average oral bioavailability is approximately 89% with a relatively uncertain half-life as long as 5-60 days ( Ducharme and Farinotti, 1996 ), with a median half-life of 21-30 days.…”